Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | |||||||||||
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![]() Structure of the N-terminal domain of the yeast Hsp90 chaperone.
[1] | |||||||||||
Identifiers | |||||||||||
Symbol | HATPase_c | ||||||||||
Pfam | PF02518 | ||||||||||
InterPro | IPR003594 | ||||||||||
SMART | HATPase_c | ||||||||||
SCOP2 | 1ei1 / SCOPe / SUPFAM | ||||||||||
CDD | cd00075 | ||||||||||
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The GHKL domain ( Gyrase, Hsp90, Histidine Kinase, MutL) is an evolutionary conserved protein domain. [2] It is an ATPase domain found in several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, [3] heat shock protein HSP90, [4] [5] [6] phytochrome-like ATPases and DNA mismatch repair proteins.
More information about this protein can be found at Protein of the Month: DNA Topoisomerase. [7]
The fold of this domain consists of two layers, alpha/beta, which contain an 8-stranded mixed beta-sheet. [2]
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() Structure of the N-terminal domain of the yeast Hsp90 chaperone.
[1] | |||||||||||
Identifiers | |||||||||||
Symbol | HATPase_c | ||||||||||
Pfam | PF02518 | ||||||||||
InterPro | IPR003594 | ||||||||||
SMART | HATPase_c | ||||||||||
SCOP2 | 1ei1 / SCOPe / SUPFAM | ||||||||||
CDD | cd00075 | ||||||||||
|
The GHKL domain ( Gyrase, Hsp90, Histidine Kinase, MutL) is an evolutionary conserved protein domain. [2] It is an ATPase domain found in several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, [3] heat shock protein HSP90, [4] [5] [6] phytochrome-like ATPases and DNA mismatch repair proteins.
More information about this protein can be found at Protein of the Month: DNA Topoisomerase. [7]
The fold of this domain consists of two layers, alpha/beta, which contain an 8-stranded mixed beta-sheet. [2]