From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Gem-associated protein 5 is a
protein that in humans is encoded by the GEMIN5
gene .
[5]
[6]
Gem-associated protein 5 is part of the
SMN a large
protein complex localized to both the
cytoplasm and the
nucleus that plays a role in the cytoplasmic assembly of
small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354),
gem-associated protein 2 (SIP1; MIM 602595),
GEMIN3 (DDX20; MIM 606168), and
GEMIN4 (MIM 606969).
[6]
GEMIN5 has been shown to
interact with
DDX20
[5]
[7] and
SMN1 .
[5]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000082516 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000037275 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
c Gubitz AK, Mourelatos Z, Abel L,
Rappsilber J , Mann M, Dreyfuss G (Feb 2002).
"Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins" . J Biol Chem . 277 (7): 5631–6.
doi :
10.1074/jbc.M109448200 .
PMID
11714716 .
^
a
b
"Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5" .
^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002).
"miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" . Genes Dev . 16 (6): 720–8.
doi :
10.1101/gad.974702 .
PMC
155365 .
PMID
11914277 .
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002).
"Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . J. Biol. Chem . 277 (35): 31957–62.
doi :
10.1074/jbc.M203478200 .
PMID
12065586 .
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006).
"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G (2006).
"The Gemin5 protein of the SMN complex identifies snRNAs" . Mol. Cell . 23 (2): 273–9.
doi :
10.1016/j.molcel.2006.05.036 .
PMID
16857593 .
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92.
doi :
10.1038/nbt1240 .
PMID
16964243 .
S2CID
14294292 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Kim EK, Noh KT, Yoon JH, Cho JH, Yoon KW, Dreyfuss G, Choi EJ (2007).
"Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5" . Cell Death Differ . 14 (8): 1518–28.
doi :
10.1038/sj.cdd.4402157 .
PMID
17541429 .
Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE (2007).
"Absence of gemin5 from SMN complexes in nuclear Cajal bodies" . BMC Cell Biol . 8 : 28.
doi :
10.1186/1471-2121-8-28 .
PMC
1939999 .
PMID
17640370 .
Battle DJ, Kasim M, Wang J, Dreyfuss G (2007).
"SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate" . J. Biol. Chem . 282 (38): 27953–9.
doi :
10.1074/jbc.M702317200 .
PMID
17640873 .