Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a
protein that in humans is encoded by the NCAPG2gene.[5][6] CAP-G2 is a subunit of
condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis[7]
Clinical importance
Mutations in this gene in humans have been associated with severe neurodevelopmental defects,
failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.[8]
Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a
protein that in humans is encoded by the NCAPG2gene.[5][6] CAP-G2 is a subunit of
condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis[7]
Clinical importance
Mutations in this gene in humans have been associated with severe neurodevelopmental defects,
failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.[8]