Fluralaner, (
INN)[12] sold under the brand name Bravecto among others, is a systemic
insecticide and
acaricide that is administered orally[13] or topically.[14] The US
Food and Drug Administration (FDA) approved it for flea treatment in dogs in May 2014,[15] and approved the combination
fluralaner/moxidectin (Bravecto Plus) as a topical treatment for cats in November 2019.[16][17][18][19] The EU approved fluralaner in March 2014.[5][6][20] Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.[21] For treating mites in chickens, a solution for use in drinking water is available under the brand name Exzolt[22] and was approved for use in the EU in 2017.[23]
Mode of action
Fluralaner inhibits
γ-aminobutyric acid (GABA)-gated chloride channels (
GABAA receptors) and L-
glutamate-gated chloride channels (GluCls).[24] Potency of fluralaner is comparable to
fipronil (a related GABA-antagonist insecticide and acaricide).[25]
^"Agricultural and Veterinary Chemicals"(PDF). Australian Pesticides and Veterinary Medicines Authority. 10 February 2015.
Archived(PDF) from the original on 19 September 2022. Retrieved 14 February 2019.
^Asahi M, Kobayashi M, Matsui H, Nakahira K (January 2015). "Differential mechanisms of action of the novel γ-aminobutyric acid receptor antagonist ectoparasiticides fluralaner (A1443) and fipronil". Pest Management Science. 71 (1): 91–95.
doi:
10.1002/ps.3768.
PMID24591229.
Fluralaner, (
INN)[12] sold under the brand name Bravecto among others, is a systemic
insecticide and
acaricide that is administered orally[13] or topically.[14] The US
Food and Drug Administration (FDA) approved it for flea treatment in dogs in May 2014,[15] and approved the combination
fluralaner/moxidectin (Bravecto Plus) as a topical treatment for cats in November 2019.[16][17][18][19] The EU approved fluralaner in March 2014.[5][6][20] Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.[21] For treating mites in chickens, a solution for use in drinking water is available under the brand name Exzolt[22] and was approved for use in the EU in 2017.[23]
Mode of action
Fluralaner inhibits
γ-aminobutyric acid (GABA)-gated chloride channels (
GABAA receptors) and L-
glutamate-gated chloride channels (GluCls).[24] Potency of fluralaner is comparable to
fipronil (a related GABA-antagonist insecticide and acaricide).[25]
^"Agricultural and Veterinary Chemicals"(PDF). Australian Pesticides and Veterinary Medicines Authority. 10 February 2015.
Archived(PDF) from the original on 19 September 2022. Retrieved 14 February 2019.
^Asahi M, Kobayashi M, Matsui H, Nakahira K (January 2015). "Differential mechanisms of action of the novel γ-aminobutyric acid receptor antagonist ectoparasiticides fluralaner (A1443) and fipronil". Pest Management Science. 71 (1): 91–95.
doi:
10.1002/ps.3768.
PMID24591229.