Clinical data | |
---|---|
Trade names | Flaxedil |
AHFS/ Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
Chemical and physical data | |
Formula | C30H60N3O3+3 · 3 I− (gallamine triethiodide) C24H45N3O3 (gallamine) |
Molar mass | 891.529 g/mol (gallamine triethiodide) 423.633 g/mol (gallamine) |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Gallamine triethiodide (Flaxedil) is a
non-depolarising muscle relaxant.
[1] It acts by combining with the
cholinergic receptor sites in
muscle and competitively blocking the transmitter action of
acetylcholine.
[2] Gallamine is a non-depolarising type of blocker as it binds to the acetylcholine receptor but does not have the
biological activity of acetyl choline. Gallamine triethiodide has a
parasympatholytic effect on the cardiac
vagus nerve, which causes
tachycardia
[3]
[4] and occasionally
hypertension. Very high doses cause
histamine release.[
citation needed]
Presence of
iodine makes it
radio opaque, and its
ampule in a bag at airport's
x-ray scanner raise the false suspicion of a
bullet in the bag.
Gallamine triethiodide was commonly used to prevent muscle contractions during surgical procedures, but now superseded by new neuromuscular blocking drugs with less side effects.
It was developed by Daniel Bovet in 1947. [5]
The drug is no longer marketed in the United States, according to the FDA Orange Book.
Clinical data | |
---|---|
Trade names | Flaxedil |
AHFS/ Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
Chemical and physical data | |
Formula | C30H60N3O3+3 · 3 I− (gallamine triethiodide) C24H45N3O3 (gallamine) |
Molar mass | 891.529 g/mol (gallamine triethiodide) 423.633 g/mol (gallamine) |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Gallamine triethiodide (Flaxedil) is a
non-depolarising muscle relaxant.
[1] It acts by combining with the
cholinergic receptor sites in
muscle and competitively blocking the transmitter action of
acetylcholine.
[2] Gallamine is a non-depolarising type of blocker as it binds to the acetylcholine receptor but does not have the
biological activity of acetyl choline. Gallamine triethiodide has a
parasympatholytic effect on the cardiac
vagus nerve, which causes
tachycardia
[3]
[4] and occasionally
hypertension. Very high doses cause
histamine release.[
citation needed]
Presence of
iodine makes it
radio opaque, and its
ampule in a bag at airport's
x-ray scanner raise the false suspicion of a
bullet in the bag.
Gallamine triethiodide was commonly used to prevent muscle contractions during surgical procedures, but now superseded by new neuromuscular blocking drugs with less side effects.
It was developed by Daniel Bovet in 1947. [5]
The drug is no longer marketed in the United States, according to the FDA Orange Book.