Dystrobrevin beta is a
protein which in humans is encoded by the DTNBgene.[5]
Function
This gene encodes dystrobrevin beta, a component of the
dystrophin-associated protein complex (
DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including
dystroglycans,
sarcoglycans,
syntrophins and
dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin.
Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
Macioce P, Gambara G, Bernassola M, et al. (2003). "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain". J. Cell Sci. 116 (Pt 23): 4847–56.
doi:
10.1242/jcs.00805.
PMID14600269.
S2CID27097248.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13.
doi:
10.1006/abio.1996.0138.
PMID8619474.
Dystrobrevin beta is a
protein which in humans is encoded by the DTNBgene.[5]
Function
This gene encodes dystrobrevin beta, a component of the
dystrophin-associated protein complex (
DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including
dystroglycans,
sarcoglycans,
syntrophins and
dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin.
Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
Macioce P, Gambara G, Bernassola M, et al. (2003). "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain". J. Cell Sci. 116 (Pt 23): 4847–56.
doi:
10.1242/jcs.00805.
PMID14600269.
S2CID27097248.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13.
doi:
10.1006/abio.1996.0138.
PMID8619474.