25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase[5] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a
cytochrome P450enzyme that in humans is encoded by the CYP27B1gene.[6][7][8]
The enzyme is also able to oxidize ercalcidiol (25-OH D2) to ercalcitriol, secalciferol to calcitetrol, and 25-hydroxy-24-oxocalciol to (1S)-1,25-dihydroxy-24-oxocalciol.[12]
^Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis". Science. 277 (5333): 1827–30.
doi:
10.1126/science.277.5333.1827.
PMID9295274.
^Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (Oct 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase". Biochemical and Biophysical Research Communications. 239 (2): 527–33.
doi:
10.1006/bbrc.1997.7508.
PMID9344864.
Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole DE, Rousseau F (Nov 2010). "High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density". Bone. 47 (5): 975–81.
doi:
10.1016/j.bone.2010.06.030.
PMID20654748.
Bu FX, Armas L, Lappe J, Zhou Y, Gao G, Wang HW, Recker R, Zhao LJ (Nov 2010). "Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects". Human Genetics. 128 (5): 549–56.
doi:
10.1007/s00439-010-0881-9.
PMID20809279.
S2CID5782938.
Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, Fichna P, Nowak J (Oct 2010). "PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients". International Journal of Immunogenetics. 37 (5): 367–72.
doi:
10.1111/j.1744-313X.2010.00935.x.
PMID20518841.
S2CID19398299.
Wjst M, Heimbeck I, Kutschke D, Pukelsheim K (Jul 2010). "Epigenetic regulation of vitamin D converting enzymes". The Journal of Steroid Biochemistry and Molecular Biology. 121 (1–2): 80–3.
doi:
10.1016/j.jsbmb.2010.03.056.
PMID20304056.
S2CID29338132.
Sunyer J, Basagaña X, González JR, Júlvez J, Guerra S, Bustamante M, de Cid R, Antó JM, Torrent M (Oct 2010). "Early life environment, neurodevelopment and the interrelation with atopy". Environmental Research. 110 (7): 733–8.
Bibcode:
2010ER....110..733S.
doi:
10.1016/j.envres.2010.07.005.
PMID20701904.
25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase[5] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a
cytochrome P450enzyme that in humans is encoded by the CYP27B1gene.[6][7][8]
The enzyme is also able to oxidize ercalcidiol (25-OH D2) to ercalcitriol, secalciferol to calcitetrol, and 25-hydroxy-24-oxocalciol to (1S)-1,25-dihydroxy-24-oxocalciol.[12]
^Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis". Science. 277 (5333): 1827–30.
doi:
10.1126/science.277.5333.1827.
PMID9295274.
^Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (Oct 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase". Biochemical and Biophysical Research Communications. 239 (2): 527–33.
doi:
10.1006/bbrc.1997.7508.
PMID9344864.
Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole DE, Rousseau F (Nov 2010). "High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density". Bone. 47 (5): 975–81.
doi:
10.1016/j.bone.2010.06.030.
PMID20654748.
Bu FX, Armas L, Lappe J, Zhou Y, Gao G, Wang HW, Recker R, Zhao LJ (Nov 2010). "Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects". Human Genetics. 128 (5): 549–56.
doi:
10.1007/s00439-010-0881-9.
PMID20809279.
S2CID5782938.
Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, Fichna P, Nowak J (Oct 2010). "PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients". International Journal of Immunogenetics. 37 (5): 367–72.
doi:
10.1111/j.1744-313X.2010.00935.x.
PMID20518841.
S2CID19398299.
Wjst M, Heimbeck I, Kutschke D, Pukelsheim K (Jul 2010). "Epigenetic regulation of vitamin D converting enzymes". The Journal of Steroid Biochemistry and Molecular Biology. 121 (1–2): 80–3.
doi:
10.1016/j.jsbmb.2010.03.056.
PMID20304056.
S2CID29338132.
Sunyer J, Basagaña X, González JR, Júlvez J, Guerra S, Bustamante M, de Cid R, Antó JM, Torrent M (Oct 2010). "Early life environment, neurodevelopment and the interrelation with atopy". Environmental Research. 110 (7): 733–8.
Bibcode:
2010ER....110..733S.
doi:
10.1016/j.envres.2010.07.005.
PMID20701904.