| Acquired progressive lymphangioma | |
|---|---|
| Other names | Benign lymphangioendothelioma |
| Specialty |
Oncology
 |
Acquired progressive lymphangioma, also known as benign lymphangioendothelioma is a group of lymphangiomas that occur anywhere in young individuals, grow slowly, and present as bruise-like lesions or erythematous macules. [1]: 597 Acquired progressive lymphangioma may develop following radiation therapy, surgery, trauma, inflammation, and tick bites. The treatment of choice is complete surgical excision.
Signs and symptoms
Acquired progressive lymphangioma appears as a slowly growing erythaematous to brownish, bruise-like, macule, plaque, or nodule typically located on the legs, head or neck. [2] The lesions are usually asymptomatic. [3]
Causes
Acquired progressive lymphangioma has been known to develop after radiation therapy, [4] surgery, [5] trauma, [6] femoral arteriography, [7] inflammation, [8] and tick bites. [9]
Mechanism
Because acquired progressive lymphangioma has been described following various traumas, it is thought to be a response to various inflammatory stimuli rather than a real neoplasm. [10]
Another possible pathogenic explanation is hormonal stimulation, as quickly growing lesions have been observed in numerous pubescent and prepubescent individuals. [11]
Finally, another idea proposed is that acquired progressive lymphangioma represents a complicated vascular hamartoma with three components: lymphatic vessels, blood vessels, and smooth muscle. [12]
Diagnosis
Acquired progressive lymphangioma has thin-walled endothelial-lined gaps interspersed between collagen strands. [2] Endothelial cells show positive staining for lymphatic markers as podoplanin (D2-40), LYVE-1, and PROX-1. Additionally, the cells have variable levels of factor VIII, Ulex europaeus agglutinin I, CD31, and CD34. [10]
Treatment
Acquired progressive lymphangioma is treated by complete surgical excision. [2]
See also
References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ a b c Jones, Edward Wilson; Winkelmann, R.K.; Zachary, C.B.; Reda, Ashraf M. (1990). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 23 (2). Elsevier BV: 229–235. doi: 10.1016/0190-9622(90)70203-t. ISSN 0190-9622. PMID 2212118.
- ^ Yamada, Sohsuke; Yamada, Yoko; Kobayashi, Miwa; Hino, Ryosuke; Nawata, Aya; Noguchi, Hirotsugu; Nakamura, Motonobu; Nakayama, Toshiyuki (2014). "Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome". Diagnostic Pathology. 9 (1): 197. doi: 10.1186/s13000-014-0197-5. ISSN 1746-1596. PMC 4215009. PMID 25358645.
- ^ Rosso, R.; Gianelli, U.; Carnevali, L. (1995). "Acquired progressive lymphangioma of the skin following radiotherapy for breast carcinoma". Journal of Cutaneous Pathology. 22 (2). Wiley: 164–167. doi: 10.1111/j.1600-0560.1995.tb01401.x. ISSN 0303-6987. PMID 7560351.
- ^ Grunwald, Marcelo H.; Amichai, Boaz; Avinoach, Ilana (1997). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 37 (4). Elsevier BV: 656–657. doi: 10.1016/s0190-9622(97)70192-0. ISSN 0190-9622. PMID 9344213.
- ^ Watanabe, Makoto; Kishiyama, Kazunori; Ohkawara, Akira (1983). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 8 (5). Elsevier BV: 663–667. doi: 10.1016/s0190-9622(83)70076-9. ISSN 0190-9622. PMID 6863623.
- ^ Kato, H.; Kadoya, A. (1996). "Acquired progressive lymphangioma occurring following femoral arteriography". Clinical and Experimental Dermatology. 21 (2): 159–162. doi: 10.1111/j.1365-2230.1996.tb00044.x. PMID 8759209.
- ^ Herron, G. Scott; Rouse, Robert V.; Kosek, Jon C.; Smoller, Bruce R.; Egbert, Barbara M. (1994). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 31 (2). Elsevier BV: 362–368. doi: 10.1016/s0190-9622(94)70173-3. ISSN 0190-9622. PMID 7518477.
- ^ Wilmera, Axel; Kaatza, Martin; Mentzelb, Thomas; Wollinaa, Uwe (1998). "Lymphangioendothelioma after a tick bite". Journal of the American Academy of Dermatology. 39 (1): 126–128. doi: 10.1016/S0190-9622(98)70416-5. PMID 9674411.
- ^ a b Vittal, Naveen kumar (2016). "Benign Lymphangioendothelioma — A Case Report". Journal of Clinical and Diagnostic Research. 10 (1). JCDR Research and Publications: WD01-2. doi: 10.7860/jcdr/2016/15664.7155. ISSN 2249-782X. PMC 4740690. PMID 26894162.
- ^ Tadaki, Takayoshi (1988-05-01). "Acquired Progressive Lymphangioma as a Flat Erythematous Patch on the Abdominal Wall of a Child". Archives of Dermatology. 124 (5): 699. doi: 10.1001/archderm.1988.01670050043017. ISSN 0003-987X. PMID 2966611.
- ^ Zhu, Wen-Yuan; Penneys, Neal S.; Reyes, Blas; Khatib, Ziad; Schachner, Lawrence (1991). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 24 (5). Elsevier BV: 813–815. doi: 10.1016/0190-9622(91)70120-q. ISSN 0190-9622. PMID 2050845.
Further reading
- Lu, Wei; Cao, Yan; Zeng, Fanhua; Chen, Chun; Yang, Zhenyu; Qi, Zuoliang; Yang, Xiaonan (2023). "Surgical Treatment for Benign Lymphangioendothelioma After Two Incomplete Excisions: A Case Report and Literature Review". Clinical, Cosmetic and Investigational Dermatology. 16. Informa UK Limited: 2697–2719. doi: 10.2147/ccid.s420019. ISSN 1178-7015. PMC 10544170.
- Guillou, Louis; Fletcher, Christopher D. M. (2000). "Benign Lymphangioendothelioma (Acquired Progressive Lymphangioma): A Lesion Not to Be Confused With Well-Differentiated Angiosarcoma and Patch Stage Kaposi's Sarcoma". The American Journal of Surgical Pathology. 24 (8). Ovid Technologies (Wolters Kluwer Health): 1047–1057. doi: 10.1097/00000478-200008000-00002. ISSN 0147-5185.
External links
| Acquired progressive lymphangioma | |
|---|---|
| Other names | Benign lymphangioendothelioma |
| Specialty |
Oncology
|
Acquired progressive lymphangioma, also known as benign lymphangioendothelioma is a group of lymphangiomas that occur anywhere in young individuals, grow slowly, and present as bruise-like lesions or erythematous macules. [1]: 597 Acquired progressive lymphangioma may develop following radiation therapy, surgery, trauma, inflammation, and tick bites. The treatment of choice is complete surgical excision.
Signs and symptoms
Acquired progressive lymphangioma appears as a slowly growing erythaematous to brownish, bruise-like, macule, plaque, or nodule typically located on the legs, head or neck. [2] The lesions are usually asymptomatic. [3]
Causes
Acquired progressive lymphangioma has been known to develop after radiation therapy, [4] surgery, [5] trauma, [6] femoral arteriography, [7] inflammation, [8] and tick bites. [9]
Mechanism
Because acquired progressive lymphangioma has been described following various traumas, it is thought to be a response to various inflammatory stimuli rather than a real neoplasm. [10]
Another possible pathogenic explanation is hormonal stimulation, as quickly growing lesions have been observed in numerous pubescent and prepubescent individuals. [11]
Finally, another idea proposed is that acquired progressive lymphangioma represents a complicated vascular hamartoma with three components: lymphatic vessels, blood vessels, and smooth muscle. [12]
Diagnosis
Acquired progressive lymphangioma has thin-walled endothelial-lined gaps interspersed between collagen strands. [2] Endothelial cells show positive staining for lymphatic markers as podoplanin (D2-40), LYVE-1, and PROX-1. Additionally, the cells have variable levels of factor VIII, Ulex europaeus agglutinin I, CD31, and CD34. [10]
Treatment
Acquired progressive lymphangioma is treated by complete surgical excision. [2]
See also
References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ a b c Jones, Edward Wilson; Winkelmann, R.K.; Zachary, C.B.; Reda, Ashraf M. (1990). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 23 (2). Elsevier BV: 229–235. doi: 10.1016/0190-9622(90)70203-t. ISSN 0190-9622. PMID 2212118.
- ^ Yamada, Sohsuke; Yamada, Yoko; Kobayashi, Miwa; Hino, Ryosuke; Nawata, Aya; Noguchi, Hirotsugu; Nakamura, Motonobu; Nakayama, Toshiyuki (2014). "Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome". Diagnostic Pathology. 9 (1): 197. doi: 10.1186/s13000-014-0197-5. ISSN 1746-1596. PMC 4215009. PMID 25358645.
- ^ Rosso, R.; Gianelli, U.; Carnevali, L. (1995). "Acquired progressive lymphangioma of the skin following radiotherapy for breast carcinoma". Journal of Cutaneous Pathology. 22 (2). Wiley: 164–167. doi: 10.1111/j.1600-0560.1995.tb01401.x. ISSN 0303-6987. PMID 7560351.
- ^ Grunwald, Marcelo H.; Amichai, Boaz; Avinoach, Ilana (1997). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 37 (4). Elsevier BV: 656–657. doi: 10.1016/s0190-9622(97)70192-0. ISSN 0190-9622. PMID 9344213.
- ^ Watanabe, Makoto; Kishiyama, Kazunori; Ohkawara, Akira (1983). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 8 (5). Elsevier BV: 663–667. doi: 10.1016/s0190-9622(83)70076-9. ISSN 0190-9622. PMID 6863623.
- ^ Kato, H.; Kadoya, A. (1996). "Acquired progressive lymphangioma occurring following femoral arteriography". Clinical and Experimental Dermatology. 21 (2): 159–162. doi: 10.1111/j.1365-2230.1996.tb00044.x. PMID 8759209.
- ^ Herron, G. Scott; Rouse, Robert V.; Kosek, Jon C.; Smoller, Bruce R.; Egbert, Barbara M. (1994). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 31 (2). Elsevier BV: 362–368. doi: 10.1016/s0190-9622(94)70173-3. ISSN 0190-9622. PMID 7518477.
- ^ Wilmera, Axel; Kaatza, Martin; Mentzelb, Thomas; Wollinaa, Uwe (1998). "Lymphangioendothelioma after a tick bite". Journal of the American Academy of Dermatology. 39 (1): 126–128. doi: 10.1016/S0190-9622(98)70416-5. PMID 9674411.
- ^ a b Vittal, Naveen kumar (2016). "Benign Lymphangioendothelioma — A Case Report". Journal of Clinical and Diagnostic Research. 10 (1). JCDR Research and Publications: WD01-2. doi: 10.7860/jcdr/2016/15664.7155. ISSN 2249-782X. PMC 4740690. PMID 26894162.
- ^ Tadaki, Takayoshi (1988-05-01). "Acquired Progressive Lymphangioma as a Flat Erythematous Patch on the Abdominal Wall of a Child". Archives of Dermatology. 124 (5): 699. doi: 10.1001/archderm.1988.01670050043017. ISSN 0003-987X. PMID 2966611.
- ^ Zhu, Wen-Yuan; Penneys, Neal S.; Reyes, Blas; Khatib, Ziad; Schachner, Lawrence (1991). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 24 (5). Elsevier BV: 813–815. doi: 10.1016/0190-9622(91)70120-q. ISSN 0190-9622. PMID 2050845.
Further reading
- Lu, Wei; Cao, Yan; Zeng, Fanhua; Chen, Chun; Yang, Zhenyu; Qi, Zuoliang; Yang, Xiaonan (2023). "Surgical Treatment for Benign Lymphangioendothelioma After Two Incomplete Excisions: A Case Report and Literature Review". Clinical, Cosmetic and Investigational Dermatology. 16. Informa UK Limited: 2697–2719. doi: 10.2147/ccid.s420019. ISSN 1178-7015. PMC 10544170.
- Guillou, Louis; Fletcher, Christopher D. M. (2000). "Benign Lymphangioendothelioma (Acquired Progressive Lymphangioma): A Lesion Not to Be Confused With Well-Differentiated Angiosarcoma and Patch Stage Kaposi's Sarcoma". The American Journal of Surgical Pathology. 24 (8). Ovid Technologies (Wolters Kluwer Health): 1047–1057. doi: 10.1097/00000478-200008000-00002. ISSN 0147-5185.