Inhibitor of Apoptosis domain | |||||||||||
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Identifiers | |||||||||||
Symbol | BIR | ||||||||||
Pfam | PF00653 | ||||||||||
InterPro | IPR001370 | ||||||||||
PROSITE | PS50143 | ||||||||||
SCOP2 | 1qbh / SCOPe / SUPFAM | ||||||||||
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The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. [2] Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 ( NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 ( xIAP), BIRC5 ( survivin) and BIRC6. [2] [3]
BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. [4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.
Inhibitor of Apoptosis domain | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||
Symbol | BIR | ||||||||||
Pfam | PF00653 | ||||||||||
InterPro | IPR001370 | ||||||||||
PROSITE | PS50143 | ||||||||||
SCOP2 | 1qbh / SCOPe / SUPFAM | ||||||||||
|
The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. [2] Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 ( NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 ( xIAP), BIRC5 ( survivin) and BIRC6. [2] [3]
BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. [4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.