Anthrax lethal factor endopeptidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]()
Crystallographic structure of anthrax lethal factor (rainbow colored cartoon,
N-terminus = blue,
C-terminus = red) complexed with the inhibitor
GM6001 (
space-filling model, carbon = white, oxygen = red, nitrogen = blue).
[1] | |||||||||
Identifiers | |||||||||
EC no. | 3.4.24.83 | ||||||||
CAS no. | 477950-41-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
Anthrax lethal factor endopeptidase ( EC 3.4.24.83, lethal toxin) is an enzyme that catalyzes the hydrolysis of mitogen-activated protein kinase kinases. This enzyme is a component of the lethal factor produced by the bacterium Bacillus anthracis. The preferred cleavage site can be denoted by BBBBxHxH, in which B denotes a basic amino acid Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. [2]
Anthrax lethal factor endopeptidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]()
Crystallographic structure of anthrax lethal factor (rainbow colored cartoon,
N-terminus = blue,
C-terminus = red) complexed with the inhibitor
GM6001 (
space-filling model, carbon = white, oxygen = red, nitrogen = blue).
[1] | |||||||||
Identifiers | |||||||||
EC no. | 3.4.24.83 | ||||||||
CAS no. | 477950-41-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
Anthrax lethal factor endopeptidase ( EC 3.4.24.83, lethal toxin) is an enzyme that catalyzes the hydrolysis of mitogen-activated protein kinase kinases. This enzyme is a component of the lethal factor produced by the bacterium Bacillus anthracis. The preferred cleavage site can be denoted by BBBBxHxH, in which B denotes a basic amino acid Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. [2]