Names | |
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IUPAC name
5-(2-cyclohexylideneethyl)-5-ethyl-1,3-diazinane-2,4,6-trione
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Other names
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Identifiers | |
3D model (
JSmol)
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ChEMBL | |
ChemSpider | |
PubChem
CID
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UNII | |
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Properties | |
C14H20N2O3 | |
Molar mass | 264.325 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
CHEB, also known as BRN 0250312 is a convulsant barbiturate. Its mechanism of action is not fully understood.
CHEB has uncommon action compared to other barbiturates. While other barbiturates such as Barbital are usually anticonvulsants, CHEB is a convulsant.
CHEB's convulsant action is not fully understood. There may be multiple mechanisms involved in its properties;
In rats, CHEB stimulates the release of glutamate, an excitatory neurotransmitter. [2]
In low doses, CHEB can block the action of glycine, thus operating in a strychnine similar way. [3]
Another study has shown that CHEB could increase the release of acetylcholine. This result was not observed with some other convulsants (S(+)-MPPB, pentylenetetrazol and Ro-5-3663), suggesting that this property is unique. [4]
Paradoxically, CHEB is able to enhance the binding of GABA, this is a strange property, as compounds that enhance GABA binding usually have anticonvulsant action, such as Diazepam. [5]
Names | |
---|---|
IUPAC name
5-(2-cyclohexylideneethyl)-5-ethyl-1,3-diazinane-2,4,6-trione
| |
Other names
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
PubChem
CID
|
|
UNII | |
| |
| |
Properties | |
C14H20N2O3 | |
Molar mass | 264.325 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
CHEB, also known as BRN 0250312 is a convulsant barbiturate. Its mechanism of action is not fully understood.
CHEB has uncommon action compared to other barbiturates. While other barbiturates such as Barbital are usually anticonvulsants, CHEB is a convulsant.
CHEB's convulsant action is not fully understood. There may be multiple mechanisms involved in its properties;
In rats, CHEB stimulates the release of glutamate, an excitatory neurotransmitter. [2]
In low doses, CHEB can block the action of glycine, thus operating in a strychnine similar way. [3]
Another study has shown that CHEB could increase the release of acetylcholine. This result was not observed with some other convulsants (S(+)-MPPB, pentylenetetrazol and Ro-5-3663), suggesting that this property is unique. [4]
Paradoxically, CHEB is able to enhance the binding of GABA, this is a strange property, as compounds that enhance GABA binding usually have anticonvulsant action, such as Diazepam. [5]