3-hydroxybutyryl-CoA dehydrogenase
3-hydroxybutyryl-CoA dehydrogenase homohexamer, Clostridium acetobutylicum
Identifiers
EC no.	1.1.1.157
CAS no.	39319-78-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 3-hydroxybutyryl-CoA dehydrogenase ( EC 1.1.1.157) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA + NADP⁺ ${\displaystyle \rightleftharpoons }$ 3-acetoacetyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoyl-CoA and NADP⁺; its 3 products are acetoacetyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxybutanoyl-CoA:NADP⁺ oxidoreductase. Other names in common use include beta-hydroxybutyryl coenzyme A dehydrogenase, L-(+)-3-hydroxybutyryl-CoA dehydrogenase, BHBD, dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine, dinucleotide phosphate), L-(+)-3-hydroxybutyryl-CoA dehydrogenase, and beta-hydroxybutyryl-CoA dehydrogenase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.

• 
  Beta-hydroxybutyryl-CoA
• 
  Acetoacetyl-CoA

References

• Madan VK, Hillmer P, Gottschalk G (1973). "Purification and properties of NADP-dependent L(+)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri". Eur. J. Biochem. 32 (1): 51–6. doi: 10.1111/j.1432-1033.1973.tb02577.x. PMID  4405720.