From Wikipedia, the free encyclopedia
2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase
Identifiers
EC no. 1.1.1.126
CAS no. 37250-55-8
Databases
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BRENDA BRENDA entry
ExPASy NiceZyme view
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MetaCyc metabolic pathway
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In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase ( EC 1.1.1.126) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconate + NADP+ (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H+

Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NADP+, whereas its 3 products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.

References

  • Preiss J, Ashwell G (February 1962). "Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid". The Journal of Biological Chemistry. 237: 317–21. PMID  14488585.


From Wikipedia, the free encyclopedia
2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase
Identifiers
EC no. 1.1.1.126
CAS no. 37250-55-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase ( EC 1.1.1.126) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconate + NADP+ (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H+

Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NADP+, whereas its 3 products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.

References

  • Preiss J, Ashwell G (February 1962). "Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid". The Journal of Biological Chemistry. 237: 317–21. PMID  14488585.



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