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Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase ZNRF1 is an
enzyme that in humans is encoded by the ZNRF1
gene.
[5]
In a study identifying genes in rat that are
upregulated in response to
nerve damage, a gene which is highly expressed in
ganglia and in the
central nervous system was found. The protein encoded by the rat gene contains both a
zinc finger and a
RING finger motif and is localized in the
endosome/
lysosome compartment, indicating that it may be involved in
ubiquitin-mediated
protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.
[5]
References
Further reading
- Hartley JL, Temple GF, Brasch MA (2001).
"DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95.
doi:
10.1101/gr.143000.
PMC
310948.
PMID
11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001).
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35.
doi:
10.1101/gr.GR1547R.
PMC
311072.
PMID
11230166.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001).
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92.
doi:
10.1093/embo-reports/kvd058.
PMC
1083732.
PMID
11256614.
- Araki T, Nagarajan R, Milbrandt J (2001).
"Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery". J. Biol. Chem. 276 (36): 34131–41.
doi:
10.1074/jbc.M104271200.
PMID
11427537.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Araki T, Milbrandt J (2003).
"ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases". J. Neurosci. 23 (28): 9385–94.
doi:
10.1523/JNEUROSCI.23-28-09385.2003.
PMC
6740566.
PMID
14561866.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
doi:
10.1038/ng1285.
PMID
14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44.
doi:
10.1101/gr.2576704.
PMC
528930.
PMID
15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8.
doi:
10.1093/nar/gkj139.
PMC
1347501.
PMID
16381901.