Protein Wnt-5b is a
protein that in humans is encoded by the WNT5Bgene.[5][6]
The
WNT gene family consists of structurally-related genes that encode secreted
signaling proteins. These proteins have been implicated in
oncogenesis and in several developmental processes, including regulation of cell fate and patterning during
embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80%
amino acid identity to the
mouse Wnt5b protein and the human
WNT5A protein, respectively. Alternative
splicing of this gene generates two
transcript variants.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". Int J Oncol. 19 (2): 347–51.
doi:
10.3892/ijo.19.2.347.
PMID11445850.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11.
doi:
10.1046/j.1432-1033.2000.01478.x.
PMID10866835.
Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med. 10 (3): 345–9.
doi:
10.3892/ijmm.10.3.345.
PMID12165812.
Protein Wnt-5b is a
protein that in humans is encoded by the WNT5Bgene.[5][6]
The
WNT gene family consists of structurally-related genes that encode secreted
signaling proteins. These proteins have been implicated in
oncogenesis and in several developmental processes, including regulation of cell fate and patterning during
embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80%
amino acid identity to the
mouse Wnt5b protein and the human
WNT5A protein, respectively. Alternative
splicing of this gene generates two
transcript variants.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". Int J Oncol. 19 (2): 347–51.
doi:
10.3892/ijo.19.2.347.
PMID11445850.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11.
doi:
10.1046/j.1432-1033.2000.01478.x.
PMID10866835.
Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med. 10 (3): 345–9.
doi:
10.3892/ijmm.10.3.345.
PMID12165812.