Protein Wnt-10b (formerly Wnt12[5]) is a
protein that in humans is encoded by the WNT10Bgene.[6][7][8][9]
The WNT gene family consists of structurally related genes that encode secreted
signaling proteins. These proteins have been implicated in
oncogenesis and in several developmental processes, including regulation of cell fate and patterning during
embryogenesis.
This gene is a member of the WNT gene family. It may be involved in
breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs
adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after
myocardial injury, by promoting
coronary vessel formation and attenuating pathological fibrosis.[10] This protein is 96% identical to the mouse Wnt10b protein at the
amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[9]
^Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.
Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805.
doi:
10.1006/bbrc.2001.4855.
PMID11350055.
Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92.
doi:
10.3892/ijo.19.6.1187.
PMID11713588.
Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment International. 28 (5): 429–32.
doi:
10.1016/S0160-4120(02)00072-7.
PMID12437293.
Protein Wnt-10b (formerly Wnt12[5]) is a
protein that in humans is encoded by the WNT10Bgene.[6][7][8][9]
The WNT gene family consists of structurally related genes that encode secreted
signaling proteins. These proteins have been implicated in
oncogenesis and in several developmental processes, including regulation of cell fate and patterning during
embryogenesis.
This gene is a member of the WNT gene family. It may be involved in
breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs
adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after
myocardial injury, by promoting
coronary vessel formation and attenuating pathological fibrosis.[10] This protein is 96% identical to the mouse Wnt10b protein at the
amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[9]
^Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.
Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805.
doi:
10.1006/bbrc.2001.4855.
PMID11350055.
Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92.
doi:
10.3892/ijo.19.6.1187.
PMID11713588.
Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment International. 28 (5): 429–32.
doi:
10.1016/S0160-4120(02)00072-7.
PMID12437293.