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Clinical data | |
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Trade names | Oxybral SR |
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Identifiers | |
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CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.015.070 |
Chemical and physical data | |
Formula | C21H26N2O3 |
Molar mass | 354.450 g·mol−1 |
3D model ( JSmol) | |
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Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids. [1]
Vincamine is sold in Europe as a prescription medicine for the treatment of primary degenerative and vascular dementia.[ citation needed] In the United States, it is permitted to be sold as a dietary supplement when labeled for use in adults for six months or less. [2] Most common preparations are in the sustained release tablet forms.
Tabersonine can be used for semi-synthesis of vincamine. [3]
Vinpocetine is a synthetic derivative of vincamine used for cerebrovascular diseases and as dietary supplement. [4] Vincamine derivatives have been also studied as anti addictive [5] and antidiabetic [6] agents.
It may have nootropic effects. [3] It has been investigated as novel anticancer drug. [7]
Concerns over long-term use have been documented by the US National Toxicology Program. [8]
![]() | |
Clinical data | |
---|---|
Trade names | Oxybral SR |
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.015.070 |
Chemical and physical data | |
Formula | C21H26N2O3 |
Molar mass | 354.450 g·mol−1 |
3D model ( JSmol) | |
| |
| |
![]() ![]() |
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids. [1]
Vincamine is sold in Europe as a prescription medicine for the treatment of primary degenerative and vascular dementia.[ citation needed] In the United States, it is permitted to be sold as a dietary supplement when labeled for use in adults for six months or less. [2] Most common preparations are in the sustained release tablet forms.
Tabersonine can be used for semi-synthesis of vincamine. [3]
Vinpocetine is a synthetic derivative of vincamine used for cerebrovascular diseases and as dietary supplement. [4] Vincamine derivatives have been also studied as anti addictive [5] and antidiabetic [6] agents.
It may have nootropic effects. [3] It has been investigated as novel anticancer drug. [7]
Concerns over long-term use have been documented by the US National Toxicology Program. [8]