Vacuolar protein sorting-associated protein 4B is a
protein that in humans is encoded by the VPS4Bgene.[5][6]
The protein encoded by this gene is a member of the
AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.
In humans, two
paralogs of the
yeast protein have been identified. They share a high degree of
amino acid sequence similarity with each other and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the
endosomal compartments, and are involved in
intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this
paralog has been mapped to
chromosome 18; the gene for the other (VPS4A) resides on
chromosome 16.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80.
doi:
10.1006/jmbi.2001.4917.
PMID11563910.
Périer F, Coulter KL, Liang H, et al. (1994). "Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast". FEBS Lett. 351 (2): 286–90.
doi:
10.1016/0014-5793(94)00879-5.
PMID8082782.
S2CID31778093.
Scheuring S, Bodor O, Röhricht RA, et al. (1999). "Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking". Gene. 234 (1): 149–59.
doi:
10.1016/S0378-1119(99)00163-8.
PMID10393249.
Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404.
doi:
10.1242/jcs.114.13.2395.
PMID11559748.
Fujita H, Umezuki Y, Imamura K, et al. (2005). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J. Cell Sci. 117 (Pt 14): 2997–3009.
doi:
10.1242/jcs.01170.
PMID15173323.
S2CID726248.
Takasu H, Jee JG, Ohno A, et al. (2005). "Structural characterization of the MIT domain from human Vps4b". Biochem. Biophys. Res. Commun. 334 (2): 460–5.
doi:
10.1016/j.bbrc.2005.06.110.
PMID16018968.
Welsch S, Habermann A, Jäger S, et al. (2007). "Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function". Traffic. 7 (11): 1551–66.
doi:
10.1111/j.1600-0854.2006.00489.x.
PMID17014699.
S2CID36879122.
Vacuolar protein sorting-associated protein 4B is a
protein that in humans is encoded by the VPS4Bgene.[5][6]
The protein encoded by this gene is a member of the
AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.
In humans, two
paralogs of the
yeast protein have been identified. They share a high degree of
amino acid sequence similarity with each other and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the
endosomal compartments, and are involved in
intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this
paralog has been mapped to
chromosome 18; the gene for the other (VPS4A) resides on
chromosome 16.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80.
doi:
10.1006/jmbi.2001.4917.
PMID11563910.
Périer F, Coulter KL, Liang H, et al. (1994). "Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast". FEBS Lett. 351 (2): 286–90.
doi:
10.1016/0014-5793(94)00879-5.
PMID8082782.
S2CID31778093.
Scheuring S, Bodor O, Röhricht RA, et al. (1999). "Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking". Gene. 234 (1): 149–59.
doi:
10.1016/S0378-1119(99)00163-8.
PMID10393249.
Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404.
doi:
10.1242/jcs.114.13.2395.
PMID11559748.
Fujita H, Umezuki Y, Imamura K, et al. (2005). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J. Cell Sci. 117 (Pt 14): 2997–3009.
doi:
10.1242/jcs.01170.
PMID15173323.
S2CID726248.
Takasu H, Jee JG, Ohno A, et al. (2005). "Structural characterization of the MIT domain from human Vps4b". Biochem. Biophys. Res. Commun. 334 (2): 460–5.
doi:
10.1016/j.bbrc.2005.06.110.
PMID16018968.
Welsch S, Habermann A, Jäger S, et al. (2007). "Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function". Traffic. 7 (11): 1551–66.
doi:
10.1111/j.1600-0854.2006.00489.x.
PMID17014699.
S2CID36879122.