Structural homology has been able to partially distinguish between cytokines that do not demonstrate a considerable degree of redundancy so that they can be classified into four types:
A more clinically and experimentally useful classification divides immunological cytokines into those that promote the proliferation and functioning of helper T-cells, type 1 (IL-1, INF-γ etc.) and type 2 ( IL-4, IL-10, IL-13, TGF-β etc.), respectively. A key focus of interest has been that cytokines in one of these two sub-sets tend to inhibit the effects of those in the other. This tendency is under intensive study for its possible role in the pathogenesis of autoimmune disorders.
Editing:
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Structural homology has been able to partially distinguish between cytokines that do not demonstrate a considerable degree of redundancy so that they can be classified into four types:
A more clinically and experimentally useful classification divides immunological cytokines into those that promote the proliferation and functioning of helper T-cells, type 1 (IL-1, INF-γ etc.) and type 2 ( IL-4, IL-10, IL-13, TGF-β etc.), respectively. A key focus of interest has been that cytokines in one of these two sub-sets tend to inhibit the effects of those in the other. This tendency is under intensive study for its possible role in the pathogenesis of autoimmune disorders.
Editing:
Other: