guanylate cyclase activator 2B (uroguanylin) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | GUCA2B | ||||||
NCBI gene | 2981 | ||||||
HGNC | 4683 | ||||||
OMIM | 601271 | ||||||
RefSeq | NM_007102 | ||||||
UniProt | Q16661 | ||||||
Other data | |||||||
Locus | Chr. 1 p34-p33 | ||||||
|
![]() | |
Identifiers | |
---|---|
3D model (
JSmol)
|
|
ChemSpider | |
MeSH | uroguanylin |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C61H101N17O25S4 | |
Molar mass | 1600.81 g·mol−1 |
Related compounds | |
Related compounds
|
PMDTA |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP. [1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
In humans, the uroguanylin peptide is encoded by the GUCA2B gene. [2] [3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice. [4]
guanylate cyclase activator 2B (uroguanylin) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | GUCA2B | ||||||
NCBI gene | 2981 | ||||||
HGNC | 4683 | ||||||
OMIM | 601271 | ||||||
RefSeq | NM_007102 | ||||||
UniProt | Q16661 | ||||||
Other data | |||||||
Locus | Chr. 1 p34-p33 | ||||||
|
![]() | |
Identifiers | |
---|---|
3D model (
JSmol)
|
|
ChemSpider | |
MeSH | uroguanylin |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C61H101N17O25S4 | |
Molar mass | 1600.81 g·mol−1 |
Related compounds | |
Related compounds
|
PMDTA |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP. [1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
In humans, the uroguanylin peptide is encoded by the GUCA2B gene. [2] [3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice. [4]