The protein encoded by this gene is a peripheral membrane protein which recycles between the
cytosol and the
Golgi apparatus during
interphase. It is regulated by
phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation.
Ras-associated protein 1 recruits this protein to coat protein complex II (
COPII) vesicles during budding from the
endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated
SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product,
GOLGA2, and giantin in a sequential manner.[10]
Brunati AM, Marin O, Folda A, Meggio F, Pinna LA (2001). "Possible implication of the Golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 Ser-940: a study with peptide substrates". Biochem. Biophys. Res. Commun. 284 (3): 817–22.
doi:
10.1006/bbrc.2001.5049.
PMID11396975.
Han SJ, Lee JH, Kim CG, Hong SH (2003). "Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport". Biochem. Biophys. Res. Commun. 300 (3): 649–55.
doi:
10.1016/S0006-291X(02)02884-X.
PMID12507498.
The protein encoded by this gene is a peripheral membrane protein which recycles between the
cytosol and the
Golgi apparatus during
interphase. It is regulated by
phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation.
Ras-associated protein 1 recruits this protein to coat protein complex II (
COPII) vesicles during budding from the
endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated
SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product,
GOLGA2, and giantin in a sequential manner.[10]
Brunati AM, Marin O, Folda A, Meggio F, Pinna LA (2001). "Possible implication of the Golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 Ser-940: a study with peptide substrates". Biochem. Biophys. Res. Commun. 284 (3): 817–22.
doi:
10.1006/bbrc.2001.5049.
PMID11396975.
Han SJ, Lee JH, Kim CG, Hong SH (2003). "Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport". Biochem. Biophys. Res. Commun. 300 (3): 649–55.
doi:
10.1016/S0006-291X(02)02884-X.
PMID12507498.