From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Golgi SNAP receptor complex member 1 is a
protein that in humans is encoded by the GOSR1
gene .
[5]
[6]
[7]
[8]
This gene encodes a trafficking
membrane protein which transports proteins among the
endoplasmic reticulum and the
Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi
SNAP receptor (SNARE) complex .
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
[8]
Interactions
GOSR1 has been shown to
interact with
USO1 ,
[9]
BET1L
[9]
[10] and
STX5 .
[9]
[11]
[12]
[13]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000108587 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000010392 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (May 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science . 272 (5265): 1161–3.
Bibcode :
1996Sci...272.1161S .
doi :
10.1126/science.272.5265.1161 .
PMID
8638159 .
S2CID
42813531 .
^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998).
"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning" . Proceedings of the National Academy of Sciences of the United States of America . 95 (14): 8175–80.
Bibcode :
1998PNAS...95.8175M .
doi :
10.1073/pnas.95.14.8175 .
PMC
20949 .
PMID
9653160 .
^ Oka T, Ungar D, Hughson FM, Krieger M (May 2004).
"The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins" . Molecular Biology of the Cell . 15 (5): 2423–35.
doi :
10.1091/mbc.E03-09-0699 .
PMC
404034 .
PMID
15004235 .
^
a
b
"Entrez Gene: GOSR1 golgi SNAP receptor complex member 1" .
^
a
b
c Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002).
"Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115" . The Journal of Cell Biology . 157 (1): 45–62.
doi :
10.1083/jcb.200112127 .
PMC
2173270 .
PMID
11927603 .
^ Xu Y, Martin S, James DE, Hong W (Oct 2002).
"GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus" . Molecular Biology of the Cell . 13 (10): 3493–507.
doi :
10.1091/mbc.E02-01-0004 .
PMC
129961 .
PMID
12388752 .
^ Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997).
"Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells" . Cell . 89 (1): 149–58.
doi :
10.1016/S0092-8674(00)80191-9 .
PMID
9094723 .
S2CID
8682509 .
^ Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998).
"Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs" . The Journal of Cell Biology . 141 (7): 1489–502.
doi :
10.1083/jcb.141.7.1489 .
PMC
2133002 .
PMID
9647643 .
^ Subramaniam VN, Loh E, Hong W (Oct 1997).
"N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF) . The Journal of Biological Chemistry . 272 (41): 25441–4.
doi :
10.1074/jbc.272.41.25441 .
PMID
9325254 .
S2CID
12818072 .
Further reading
Nagahama M, Orci L, Ravazzola M, Amherdt M, Lacomis L, Tempst P, Rothman JE, Söllner TH (May 1996).
"A v-SNARE implicated in intra-Golgi transport" . The Journal of Cell Biology . 133 (3): 507–16.
doi :
10.1083/jcb.133.3.507 .
PMC
2120813 .
PMID
8636227 .
Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997).
"Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells" . Cell . 89 (1): 149–58.
doi :
10.1016/S0092-8674(00)80191-9 .
PMID
9094723 .
S2CID
8682509 .
Subramaniam VN, Loh E, Hong W (Oct 1997).
"N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF) . The Journal of Biological Chemistry . 272 (41): 25441–4.
doi :
10.1074/jbc.272.41.25441 .
PMID
9325254 .
S2CID
12818072 .
Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998).
"Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs" . The Journal of Cell Biology . 141 (7): 1489–502.
doi :
10.1083/jcb.141.7.1489 .
PMC
2133002 .
PMID
9647643 .
Bui TD, Levy ER, Subramaniam VN, Lowe SL, Hong W (Apr 1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17". Genomics . 57 (2): 285–8.
doi :
10.1006/geno.1998.5649 .
PMID
10198168 .
Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (Apr 2000).
"GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28" . The EMBO Journal . 19 (7): 1494–504.
doi :
10.1093/emboj/19.7.1494 .
PMC
310219 .
PMID
10747018 .
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000).
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Research . 10 (10): 1546–60.
doi :
10.1101/gr.140200 .
PMC
310934 .
PMID
11042152 .
Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002).
"Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115" . The Journal of Cell Biology . 157 (1): 45–62.
doi :
10.1083/jcb.200112127 .
PMC
2173270 .
PMID
11927603 .
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (Jun 2002).
"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells" . Immunity . 16 (6): 779–90.
doi :
10.1016/S1074-7613(02)00324-2 .
PMID
12121660 .
Xu Y, Martin S, James DE, Hong W (Oct 2002).
"GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus" . Molecular Biology of the Cell . 13 (10): 3493–507.
doi :
10.1091/mbc.E02-01-0004 .
PMC
129961 .
PMID
12388752 .
Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004).
"Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network" . Molecular Biology of the Cell . 15 (9): 4011–22.
doi :
10.1091/mbc.E03-12-0876 .
PMC
515336 .
PMID
15215310 .
Arasaki K, Taniguchi M, Tani K, Tagaya M (Jun 2006).
"RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex" . Molecular Biology of the Cell . 17 (6): 2780–8.
doi :
10.1091/mbc.E05-10-0973 .
PMC
1474792 .
PMID
16571679 .