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Does anyone know why Merck discovered these but never brought them into clinical trials? My guess is that in 1993 when discovered, the statins were more than adequate for lowering cholesterol (or at least in making money from lowering cholesterol) or the synthesis or isolation was not adequate before the patent expired. Alternatively, perhaps it is because they also inhibit farnesyl transferase (I think, can't find reference right now), so specificity may be an issue. Bform ( talk) 15:22, 3 March 2008 (UTC)
Article says they "vary in their 1-alkyl and their 6-acyl side chains" - but exactly how ? Is the diagram of the A variant ? Rod57 ( talk) 14:32, 24 August 2010 (UTC)
![]() | This article is rated Stub-class on Wikipedia's
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Does anyone know why Merck discovered these but never brought them into clinical trials? My guess is that in 1993 when discovered, the statins were more than adequate for lowering cholesterol (or at least in making money from lowering cholesterol) or the synthesis or isolation was not adequate before the patent expired. Alternatively, perhaps it is because they also inhibit farnesyl transferase (I think, can't find reference right now), so specificity may be an issue. Bform ( talk) 15:22, 3 March 2008 (UTC)
Article says they "vary in their 1-alkyl and their 6-acyl side chains" - but exactly how ? Is the diagram of the A variant ? Rod57 ( talk) 14:32, 24 August 2010 (UTC)