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The contents of the Optimal biological dose page were merged into Therapeutic index on 27 Aug 2015. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
targeting actually does effect the theraputic index as it lowers the effective dose and if it sequesters the drug well enough can increase the lethal dose —Preceding unsigned comment added by Jkuech1 ( talk • contribs) 16:38, 26 March 2008 (UTC)
Does anyone have anything to add regarding the history of this phrase, when it was coined and when its use became common in the literature? Or are there any references I should look u to find this information out myself? Turkeyphan t 16:05, 3 August 2009 (UTC)
Shouldn't LD50 be replaced by TD50? The Therapeutic Index is the quotient of the Toxic Dose and the Effective Dose, not the Lethal Dose. 89.146.16.26 ( talk) 09:00, 28 September 2009 (UTC)
I propose we remove the above refuted proposal, "Incorrect Term". -Alan —Preceding
unsigned comment added by
166.137.10.83 (
talk)
15:24, 5 October 2010 (UTC)
I would like to see a list of some examples. I found a few in other articles, such as
the section on toxicity in the article about Tetrahydrocannabinol.
Qbert203 (
talk)
00:19, 24 January 2011 (UTC)
In this article, the therapeutic index of heroin is stated to be 10. This is the lowest estimate I have ever seen, and it has no quotations around it. Experimental studies obviously cannot be performed on humans, but the therapeutic index for monkeys has been found to be 50.
Heroin overdose might actually be most often due to mixing with synergistic depressants, instead of its own toxicity.
Furthermore, there is no evidence provided that heroin overdose is more likely than alcohol overdose, which is also very dubious. — Preceding unsigned comment added by Vivamoque ( talk • contribs) 18:28, 8 February 2014 (UTC)
Sources to be found here: http://www.druglibrary.org/schaffer/Library/studies/cu/cu12.htm
For the time being, I'm removing this section of the article, as it does not citations provided, and the review I have provided directly refutes it. — Preceding unsigned comment added by Vivamoque ( talk • contribs) 18:26, 8 February 2014 (UTC)
http://pharmacologycorner.com/therapeutic-index/ — Preceding unsigned comment added by 173.65.154.242 ( talk) 04:29, 22 May 2014 (UTC)
The therapeutic window article has a huge amount of overlap and is a poor quality stub. They should be merged and if there is any difference between the two it should be detailed here. Testem ( talk) 21:28, 5 January 2015 (UTC)
Article merged: See old talk-page here. Klbrain ( talk) 20:47, 27 August 2015 (UTC)
Incoming merges have been completed from:
Klbrain ( talk) 22:01, 4 October 2015 (UTC)
The term Margin of safety (medicine) redirects here but is not explained nor even mentioned. This is confusing. MoS is used in cosmetics and pharmaceutical APIs for risk assessments and found in Wikipedia but lacking any description.-- Himbear ( talk) 09:08, 14 November 2016 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
|
The contents of the Optimal biological dose page were merged into Therapeutic index on 27 Aug 2015. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
targeting actually does effect the theraputic index as it lowers the effective dose and if it sequesters the drug well enough can increase the lethal dose —Preceding unsigned comment added by Jkuech1 ( talk • contribs) 16:38, 26 March 2008 (UTC)
Does anyone have anything to add regarding the history of this phrase, when it was coined and when its use became common in the literature? Or are there any references I should look u to find this information out myself? Turkeyphan t 16:05, 3 August 2009 (UTC)
Shouldn't LD50 be replaced by TD50? The Therapeutic Index is the quotient of the Toxic Dose and the Effective Dose, not the Lethal Dose. 89.146.16.26 ( talk) 09:00, 28 September 2009 (UTC)
I propose we remove the above refuted proposal, "Incorrect Term". -Alan —Preceding
unsigned comment added by
166.137.10.83 (
talk)
15:24, 5 October 2010 (UTC)
I would like to see a list of some examples. I found a few in other articles, such as
the section on toxicity in the article about Tetrahydrocannabinol.
Qbert203 (
talk)
00:19, 24 January 2011 (UTC)
In this article, the therapeutic index of heroin is stated to be 10. This is the lowest estimate I have ever seen, and it has no quotations around it. Experimental studies obviously cannot be performed on humans, but the therapeutic index for monkeys has been found to be 50.
Heroin overdose might actually be most often due to mixing with synergistic depressants, instead of its own toxicity.
Furthermore, there is no evidence provided that heroin overdose is more likely than alcohol overdose, which is also very dubious. — Preceding unsigned comment added by Vivamoque ( talk • contribs) 18:28, 8 February 2014 (UTC)
Sources to be found here: http://www.druglibrary.org/schaffer/Library/studies/cu/cu12.htm
For the time being, I'm removing this section of the article, as it does not citations provided, and the review I have provided directly refutes it. — Preceding unsigned comment added by Vivamoque ( talk • contribs) 18:26, 8 February 2014 (UTC)
http://pharmacologycorner.com/therapeutic-index/ — Preceding unsigned comment added by 173.65.154.242 ( talk) 04:29, 22 May 2014 (UTC)
The therapeutic window article has a huge amount of overlap and is a poor quality stub. They should be merged and if there is any difference between the two it should be detailed here. Testem ( talk) 21:28, 5 January 2015 (UTC)
Article merged: See old talk-page here. Klbrain ( talk) 20:47, 27 August 2015 (UTC)
Incoming merges have been completed from:
Klbrain ( talk) 22:01, 4 October 2015 (UTC)
The term Margin of safety (medicine) redirects here but is not explained nor even mentioned. This is confusing. MoS is used in cosmetics and pharmaceutical APIs for risk assessments and found in Wikipedia but lacking any description.-- Himbear ( talk) 09:08, 14 November 2016 (UTC)