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Senescence article. This is not a forum for general discussion of the article's subject. |
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There's a study from Paul Nelson, professor of ecology and evolutionary biology and at the University of Arizona, and Joanna Masel, a postdoc researcher from the same university, stating that mathematically, it is impossible to beat aging, and their study is titled as "Intercellular competition and the inevitability of multicellular aging"
http://www.pnas.org/content/114/49/12982
Should we add this to the article?-- EPN-001GF IZEN བཀྲ་ཤིས་བདེ་ལེགས། 08:52, 27 January 2018 (UTC)
Currently the hatnote reads, This article is about the aging of whole organisms including animals. For the state of cellular growth arrest and aberrant secretory phenotype, see cellular senescence. For aging specifically in humans, see aging. For the study of aging in humans, see gerontology. For the science of the care of the elderly, see geriatrics. For experimental gerontology, see life extension. For the stress- and age-related developmental aging phenomena in plants, see plant senescence. For premature aging disorders, see Progeroid syndromes. This seems excessive and contrary to guidelines. MOS:HATNOTE says hatnotes are "short notes" and "limit hatnotes to just one at the top of the page". This one is eight sentences disambiguating many different topics. Any suggestions for simplifying this? Are the linked topics suitable for a single disambiguation page? Deli nk ( talk) 19:05, 15 May 2018 (UTC)
Roc Ordman has developed a nutritional supplement, Mito-C, containing 11 ingredients specifically selected to reduce the rate of protein misfolding. He recently submitted a scientific article to the Journal of Nutrition and Supplements describing how the ingredients work. Among them are EGCG from green tea and quercetin from blueberries which slow the rate of mRNA translation. Also included are two amino acids which are deficient in most people's diets, causing improper amino acids to be substituted during translation. Read the paper at the link at TriumphHealthCorp.com. Email roc@ordman.net for further information. Rocordman ( talk) 17:16, 27 September 2019 (UTC)
User:Zefr placed a sentence on gingko that I edited to blend into the rest of the section, and then has repeatedly reverted my edits and restored that sentence without doing anything to improve it in response to in-line comments. I am moving the dispute here to talk.
The section is on variation in senescence among species. The sentence talks about senescence being slow (but positive) in ginkgo. The sentence placement was right after to a sentence on negative senescence, suggesting a link but not providing the evidence that senescence is negative. It contained non-notable information eg year of publication and place that gingkos grow, that is disproportionate with treatment of other species - this in a vital article that has repeatedly suffered from bloat. I have moved the reference and the ginkgo example to the sentence that contains other species with positive senescence, creating a direct comparison between mice, men, and gingkos, with the most words given to the last of these.
In the last edit, details on mechanism were given. They do not belong in this section unless they are rewritten to relate to variation among species, not just to ginkgo. Joannamasel ( talk) 22:03, 21 January 2020 (UTC)
I think it would be good to also list or mention or maybe briefly inform about the conclusions/findings from this study. It's currently included in 2022 in science like so:
A study shows the clonal diversity of stem cells that produce blood cells gets drastically reduced around age 70 to a faster-growing few, substantiating a novel theory of ageing which could enable healthy aging. [1] [2]
Moreover, it seems like the article needs a lot of updates / improvements beyond that. It seems to focus too much on the initial 2013 hallmarks of aging without integrating expansions/revisions of/additions to these. This doesn't mean the article should grow much larger or that sections should be long – each section should be as brief as possible and have a fitting headline, various things could be listed via brief bullet-points with further info only at the respective wikilinked article, and so on – the article just shouldn't be very incomplete and outdated. Maybe you can find some relevant info/content at Timeline of senescence research and recently expanded (imo a v1.0 now) Life extension#Strategies.
Maybe
transclusions could be used in good ways with articles like
Ageing so that each article is up-to-date, brief, complete and doesn't duplicate content more than needed.
Prototyperspective (
talk)
11:44, 3 August 2022 (UTC)
References
This is the
talk page for discussing improvements to the
Senescence article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find sources: Google ( books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL |
Archives: Index, 1Auto-archiving period: 90 days |
This
level-5 vital article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
To-do list for Senescence:
Priority 3
|
This article is substantially duplicated by a piece in an external publication. Please do not flag this article as a copyright violation of the following source:
|
There's a study from Paul Nelson, professor of ecology and evolutionary biology and at the University of Arizona, and Joanna Masel, a postdoc researcher from the same university, stating that mathematically, it is impossible to beat aging, and their study is titled as "Intercellular competition and the inevitability of multicellular aging"
http://www.pnas.org/content/114/49/12982
Should we add this to the article?-- EPN-001GF IZEN བཀྲ་ཤིས་བདེ་ལེགས། 08:52, 27 January 2018 (UTC)
Currently the hatnote reads, This article is about the aging of whole organisms including animals. For the state of cellular growth arrest and aberrant secretory phenotype, see cellular senescence. For aging specifically in humans, see aging. For the study of aging in humans, see gerontology. For the science of the care of the elderly, see geriatrics. For experimental gerontology, see life extension. For the stress- and age-related developmental aging phenomena in plants, see plant senescence. For premature aging disorders, see Progeroid syndromes. This seems excessive and contrary to guidelines. MOS:HATNOTE says hatnotes are "short notes" and "limit hatnotes to just one at the top of the page". This one is eight sentences disambiguating many different topics. Any suggestions for simplifying this? Are the linked topics suitable for a single disambiguation page? Deli nk ( talk) 19:05, 15 May 2018 (UTC)
Roc Ordman has developed a nutritional supplement, Mito-C, containing 11 ingredients specifically selected to reduce the rate of protein misfolding. He recently submitted a scientific article to the Journal of Nutrition and Supplements describing how the ingredients work. Among them are EGCG from green tea and quercetin from blueberries which slow the rate of mRNA translation. Also included are two amino acids which are deficient in most people's diets, causing improper amino acids to be substituted during translation. Read the paper at the link at TriumphHealthCorp.com. Email roc@ordman.net for further information. Rocordman ( talk) 17:16, 27 September 2019 (UTC)
User:Zefr placed a sentence on gingko that I edited to blend into the rest of the section, and then has repeatedly reverted my edits and restored that sentence without doing anything to improve it in response to in-line comments. I am moving the dispute here to talk.
The section is on variation in senescence among species. The sentence talks about senescence being slow (but positive) in ginkgo. The sentence placement was right after to a sentence on negative senescence, suggesting a link but not providing the evidence that senescence is negative. It contained non-notable information eg year of publication and place that gingkos grow, that is disproportionate with treatment of other species - this in a vital article that has repeatedly suffered from bloat. I have moved the reference and the ginkgo example to the sentence that contains other species with positive senescence, creating a direct comparison between mice, men, and gingkos, with the most words given to the last of these.
In the last edit, details on mechanism were given. They do not belong in this section unless they are rewritten to relate to variation among species, not just to ginkgo. Joannamasel ( talk) 22:03, 21 January 2020 (UTC)
I think it would be good to also list or mention or maybe briefly inform about the conclusions/findings from this study. It's currently included in 2022 in science like so:
A study shows the clonal diversity of stem cells that produce blood cells gets drastically reduced around age 70 to a faster-growing few, substantiating a novel theory of ageing which could enable healthy aging. [1] [2]
Moreover, it seems like the article needs a lot of updates / improvements beyond that. It seems to focus too much on the initial 2013 hallmarks of aging without integrating expansions/revisions of/additions to these. This doesn't mean the article should grow much larger or that sections should be long – each section should be as brief as possible and have a fitting headline, various things could be listed via brief bullet-points with further info only at the respective wikilinked article, and so on – the article just shouldn't be very incomplete and outdated. Maybe you can find some relevant info/content at Timeline of senescence research and recently expanded (imo a v1.0 now) Life extension#Strategies.
Maybe
transclusions could be used in good ways with articles like
Ageing so that each article is up-to-date, brief, complete and doesn't duplicate content more than needed.
Prototyperspective (
talk)
11:44, 3 August 2022 (UTC)
References