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To write this, I will need to read PMID  15336975 JFW |  T@lk 14:24, 9 May 2005 (UTC) reply

Here's a good source: http://pharmrev.aspetjournals.org/cgi/content/full/49/1/1 KBi 04:53, 15 November 2005 (UTC) reply

Wouldn't you add the full academic references and cite the key points in the article? JFW |  T@lk 07:51, 15 November 2005 (UTC) reply

You're evil! It's 51 pages long! JFW |  T@lk 20:12, 15 November 2005 (UTC) reply

This should be incorporated here:

• The ryanodine receptor is named after the plant alkaloid ryanodine. It is similar to the InsP₃ receptor and stimulated to transport Ca²⁺ into the cytosol by recognizing Ca²⁺ on its cytosolic side, thus establishing a feedback mechanism; a small amount of Ca²⁺ in the cytosol near the receptor will cause it to release even more Ca²⁺. It is especially important in neurons and muscle cells. In heart and pancreas cells, another second messenger ( cyclic ADP ribose) takes part in the receptor activation.

The localized and time-limited activity of Ca²⁺ in the cytosol is also called a Ca²⁺ wave. The building of the wave is done by

• the feedback mechanism of the ryanodine receptor and
• the activation of phospholipase C by Ca²⁺, which leads to the production of inositol triphosphate, which in turn activates the InsP₃ receptor.

JFW |  T@lk 18:27, 9 May 2005 (UTC) reply

Im pretty sure that myasthenia gravis is a disease caused by antibodies against Ach receptors

Sure, but the 10% who are negative often have antibodies against other skeletal muscle proteins, such as MuSK and apparently also RyR1. JFW |  T@lk 10:08, 26 March 2008 (UTC) reply

Why is there no article about the DHP receptor? 129.31.72.52 13:50, 20 May 2007 (UTC) reply

WP:BOLD, create it! Or rather, get a username and then create it. JFW |  T@lk 10:08, 26 March 2008 (UTC) reply

Don't you think this process fundamental to cardiac physiology requires its own page (i.e. it doesn't redirect to this ryanodine receptor article)? Butterfly reflections 04:15, 27 May 2007 (UTC) reply

{{ sofixit}} JFW |  T@lk 10:08, 26 March 2008 (UTC) reply

RYR1 apparently plays a significant role in muscle fatigue: doi: 10.1172/JCI34006 JFW |  T@lk 10:08, 26 March 2008 (UTC) reply

I removed an existing (un-referenced) line about the "many" protein interactions involving RyR. Also cleanup up the section and added a reference. Would be nice to see more interactions listed (if, indeed, they do exist and can be properly cited!) Clayt85 ( talk) 14:03, 22 May 2014 (UTC) reply

This article was the subject of a Wiki Education Foundation-supported course assignment, between 30 January 2023 and 20 May 2023. Further details are available on the course page. Student editor(s): PolyMurrase ( article contribs).

— Assignment last updated by Bubbstar ( talk) 20:11, 15 May 2023 (UTC) reply