This is the
talk page for discussing improvements to the
Retinitis pigmentosa article. This is not a forum for general discussion of the article's subject. |
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Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
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To-do list for Retinitis pigmentosa:
See WP:MEDMOS for style suggestions Priority 4
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Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Retinitis pigmentosa.
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Here's an interesting article for those involved with this article: "Chip improves vision, baffles scientists" - hope someone can find this useful and incorporate it. violet/riga (t) 21:14, 5 Apr 2005 (UTC)
I have removed the following paragraph from this section:
This information may be "from scientifically peer reviewed and accepted journals" but it is not readily obvious to the average Wiki reader why it should be included here. Please tie-in to the treatment of RP for inclusion. AED 06:01, 27 September 2005 (UTC)
I was doing a project on Retinitis Pigmentosa and thought that I could point out that the same pictures on the wikipedia article are available in a colored format at http://blindness.org/content.asp?id=45. If an expert wikipedia has time, please change the images.
While maybe not be considared a treatment per se, I have in the past (and will in the future once finances straiten out.), taken Vitimin A Daily. I belive it is sometming like 15,000 IUs. This slows the degernerative process.
The NIH seems to think that taking 15,000 IU's daily of vitamin A may slow the degenerative process : http://www.nei.nih.gov/news/clinicalalerts/alert-rp.asp
This discovery was made by the Harvard Medical School Berman-Gund Laboratory for the Study of Retinal Degenerations in Boston, situated at the Mass. Eye and Ear Infirmary. I will see if I can find the original paper. Here is one by the same laboratory in which they test Vitamin A supplementation in mice engineered to mimic a rhodopsin mutation (a common form of Retinitis pigmentosa). They produced the original research including human trials. They also determined that excess amounts of Vitamin E leads RP to speed up noticeably. Typical suggestions from ophthalmologists to patients therefore usually consist of "Take vitamin A supplements and avoid vitamin E." Berman-Gund has also proven that avoiding light preserves the morphology of the retina for longer periods of time, and slows the progression of loss of visual acuity.
It is noted within the background information of the study that this work was done by Berman-Gund.
I have added a couple of links to summaries of the Berman-Gund papers to the main article. In case you need the original articles, you can request a copy of them to the corresponding author. BTW, safety of 15,000 IU vit. A has been tested [1]. C. Rivolta —The preceding unsigned comment was added by 130.223.204.146 ( talk)
The name, in particular the -itis suffix, implies that inflammation is involved. What is inflamed? Aaadddaaammm 07:56, 17 October 2006 (UTC)
I don't know how to fix links, but in the second paragraph of the Diagnosis section "autosomal dominant" and "autosomal recessive" would be better links than "dominant" and "recessive". Both already have their own page on Wiki. 70.188.232.151 09:02, 8 March 2007 (UTC)cH
Diagnosis needs updating. There are at least 341 known disease causing mutations across 13 genes for RP. Also, loci and genes are not the same thing. Loci refers to the specific location of a genetic abberation, e.g. RHOp23H, whereas gene referes to the entire protein coding region of the genome. 165.118.1.50 06:48, 8 October 2007 (UTC)
Their is a paragraph in the "See Also" section that doesn't belong there and is written very poorly and doesn't make sense. :-/ —Preceding unsigned comment added by 68.236.141.248 ( talk) 19:32, 24 February 2008 (UTC)
The sections headed "Signs", "Diagnosis" and "Genetics" read more like a medical textbook than an encyclopaedia and need to be rewritten to be comprehensible to the man on the street. I have wikilinked as much as I can but there are words such as "digenic" and "nonsyndromic" and phrases such as "the visual transduction cascade" which can't be linked and would have no obvious meaning to most people. Richerman ( talk) 15:13, 23 April 2008 (UTC)
I suggest to add the term rod-cone dystrophy. It is used to distinguish Retinitis pigmentosa (rod-cone dystrophy) from inversa retinitis pigmentosa (cone-rod dystrophy) —Preceding unsigned comment added by 151.53.240.221 ( talk) 07:15, 20 May 2008 (UTC)
The intro is poorly written. Would anyone like to make changes or shall I take care of it?
AriaNo11 ( talk) 18:28, 19 June 2010 (UTC)
Any objections to moving the list of notable RP sufferers to a separate article ? Rod57 ( talk) 14:00, 25 June 2010 (UTC)
I could not verify that Kevin James has RP. I found one article mentioning that *his sister* has it. — Preceding
unsigned comment added by
Rssnkgp02 (
talk •
contribs) 02:14, 4 January 2011 (UTC)
Surely we need a section on treatment or management of RP - or at least say there are no treatments if that's the case. Rod57 ( talk) 14:00, 25 June 2010 (UTC)
There is a spoken file of old version of this article.
Is it lost or it was intentionally removed? I don't know. -- Andrew Krizhanovsky ( talk) 17:50, 10 August 2011 (UTC)
A child displaying signs of RP may fall often, hit their heads on overhanging furniture or play structures, lose themselves in a darkened room or have difficulty locating objects. These signs are due to the reduced night vision and tunnel vision associated with RP. 198.103.167.20 ( talk) 17:26, 18 October 2011 (UTC)
3 of my siblings have retinitis pigmentosa. . .they would object to the language "suffering with". They do not "suffer" because of RP, they adapt and thrive. Better language would be "people who have rp", "people experience RP", "people with rp".
Thanks for considering making the language more empowering and less disabling.
Colleen Erb — Preceding unsigned comment added by 205.196.128.3 ( talk) 14:57, 9 June 2013 (UTC)
Hi all,
After spending a bit of time studying the manifestation and treatments available for retinitis pigmentosa, I feel like it is important to strengthen and substantiate the "treatment" section of the wikipedia article. While it currently focuses primarily on Argus II and vitamin treatments, information regarding additional therapies (such as induced pluripotent stem cell transplantation or embryonic stem cell transplantation) and alternative prosthetic devices would solidify the "Treatment" section. I am currently researching and gathering data regarding this topic, and hope to contribute significant information to strengthen the overall content of the article.
Meanwhile, here is an article that I find interesting regarding RP therapies and treatments. http://www.nature.com/news/curing-blindness-vision-quest-1.15875?WT.ec_id=NATURE-20140911 [1]
This article was the subject of an educational assignment in Spring 2015. Further details were available on the "Education Program:Saint Louis University/SLU Biology 496 (Spring 2015)" page, which is now unavailable on the wiki. |
Here are some sources that I will be using during my research. I will continue to add possible sources and develop a more structured bibliography. Please feel free to recommend any relevant sources and evaluate my list of article options that I have compiled thus far.
PubMed article, Retinitis Pigmentosa" [2]
PubMed article providing an overview of disease presentation, pathology, and treatment [3]
Orphanet Journal of Rare Diseases [4]
Transplanting retinal pigment epithelium [5]
Therapeutic techniques - prosthetic devices, gene therapy, stem cell [6]
Mechanism of the rod degeneration and cell death [7] [8]
Thanks!
Carolynslu ( talk) 19:51, 28 February 2015 (UTC)
References
Here are a list of some my project goals while reconstructing the Retinitis Pigmentosa Wikipedia article
I will continue to update this list of goals as my research continues!
Carolynslu ( talk) 02:54, 10 March 2015 (UTC)
As a part of assignment I will be peer-reviewing an article used in the article about [[Retinitis pigmentosa]. The article in question is a comprehensive review about Retinitis pigmentosa and covers a lot of the more basic and some advanced information about the disorder. The article can be found here: [2]
Overall, the review done in this article for the disorder is very well written. It encompasses a lot of the basic facts that are required to understand Retinitis pigmentosa. In addition, it goes into a lot of detail about the causes and pathology of retinitis pigmentosa.
Overall, the article is very critical in the future development of the Retinitis Pigmentosa page. It has a lot of great information that is used. Good choice is picking such a comprehensive review article.
Hey Carolyn, your article looks really well done. I am really enjoying all the information you have gathered, pictures, and tables that you were able to find. They contribute really well to the overall flow and ease of information.
Again really well done, the article really has taken a good shape for the final form. VarunS93 ( talk) 23:07, 27 April 2015 (UTC) VarunS93 ( talk) 22:59, 27 April 2015 (UTC) VarunS93 ( talk) 20:44, 8 April 2015 (UTC)
— Preceding unsigned comment added by VarunS93 ( talk • contribs) 20:34, 8 April 2015 (UTC)
Lately there's been a lot of research on the photopigment melanopsin (peak sensitivity 480 mn). We have it on our ipRGCs (Intrinsically photosensitive retinal ganglion cells). (It's also in our skin and brains.) In one study, two elderly Japanese people who were profoundly blind with Retinitis pigmentosa were found to have pupil response that peaked at 480 nm. There is also indication that such people can sense the presence or absence of light. In blind mice with no rods or cones, they've been able to amp up the Melanopsin and get them to pass simple vision tests. Zyxwv99 ( talk) 21:09, 18 October 2015 (UTC)
http://articles.latimes.com/1993-02-28/news/mn-231_1_retinitis-pigmentosa
Notable case - perhaps. (also mentioned, briefly, in http://history.nasa.gov/sp482.pdf on page 51 of the pdf, p46 of the printed book - NASA SP-482 -THE IMPACT OF SCIENCE ON SOCIETY - James Burke - Jules Bergman - Isaac Asimov ). 213.222.172.165 ( talk) 23:15, 5 July 2016 (UTC).
Retinitis pigmentosa has an array of identifyingCite error: There are <ref>
tags on this page without content in them (see the
help page). features. These include night blindness, a decrease in peripheral vision, narrowing of the retinal vessels, and the movement of pigment from disrupted retinal pigment epithelium into the retina, forming clumps. These darker clumps of pigment are the hallmark of the disorder.
Mp214 (
talk) 17:59, 25 April 2018 (UTC)
This just arrived by way of CNN: Blind man has sight partially restored after 40 years. The CNN article reference a newly published paper from Nature Medicine journal: Partial recovery of visual function in a blind patient after optogenetic therapy.
Jeffrey Walton ( talk) 04:00, 4 June 2021 (UTC)
This is the
talk page for discussing improvements to the
Retinitis pigmentosa article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
|
To-do list for Retinitis pigmentosa:
See WP:MEDMOS for style suggestions Priority 4
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Retinitis pigmentosa.
|
Here's an interesting article for those involved with this article: "Chip improves vision, baffles scientists" - hope someone can find this useful and incorporate it. violet/riga (t) 21:14, 5 Apr 2005 (UTC)
I have removed the following paragraph from this section:
This information may be "from scientifically peer reviewed and accepted journals" but it is not readily obvious to the average Wiki reader why it should be included here. Please tie-in to the treatment of RP for inclusion. AED 06:01, 27 September 2005 (UTC)
I was doing a project on Retinitis Pigmentosa and thought that I could point out that the same pictures on the wikipedia article are available in a colored format at http://blindness.org/content.asp?id=45. If an expert wikipedia has time, please change the images.
While maybe not be considared a treatment per se, I have in the past (and will in the future once finances straiten out.), taken Vitimin A Daily. I belive it is sometming like 15,000 IUs. This slows the degernerative process.
The NIH seems to think that taking 15,000 IU's daily of vitamin A may slow the degenerative process : http://www.nei.nih.gov/news/clinicalalerts/alert-rp.asp
This discovery was made by the Harvard Medical School Berman-Gund Laboratory for the Study of Retinal Degenerations in Boston, situated at the Mass. Eye and Ear Infirmary. I will see if I can find the original paper. Here is one by the same laboratory in which they test Vitamin A supplementation in mice engineered to mimic a rhodopsin mutation (a common form of Retinitis pigmentosa). They produced the original research including human trials. They also determined that excess amounts of Vitamin E leads RP to speed up noticeably. Typical suggestions from ophthalmologists to patients therefore usually consist of "Take vitamin A supplements and avoid vitamin E." Berman-Gund has also proven that avoiding light preserves the morphology of the retina for longer periods of time, and slows the progression of loss of visual acuity.
It is noted within the background information of the study that this work was done by Berman-Gund.
I have added a couple of links to summaries of the Berman-Gund papers to the main article. In case you need the original articles, you can request a copy of them to the corresponding author. BTW, safety of 15,000 IU vit. A has been tested [1]. C. Rivolta —The preceding unsigned comment was added by 130.223.204.146 ( talk)
The name, in particular the -itis suffix, implies that inflammation is involved. What is inflamed? Aaadddaaammm 07:56, 17 October 2006 (UTC)
I don't know how to fix links, but in the second paragraph of the Diagnosis section "autosomal dominant" and "autosomal recessive" would be better links than "dominant" and "recessive". Both already have their own page on Wiki. 70.188.232.151 09:02, 8 March 2007 (UTC)cH
Diagnosis needs updating. There are at least 341 known disease causing mutations across 13 genes for RP. Also, loci and genes are not the same thing. Loci refers to the specific location of a genetic abberation, e.g. RHOp23H, whereas gene referes to the entire protein coding region of the genome. 165.118.1.50 06:48, 8 October 2007 (UTC)
Their is a paragraph in the "See Also" section that doesn't belong there and is written very poorly and doesn't make sense. :-/ —Preceding unsigned comment added by 68.236.141.248 ( talk) 19:32, 24 February 2008 (UTC)
The sections headed "Signs", "Diagnosis" and "Genetics" read more like a medical textbook than an encyclopaedia and need to be rewritten to be comprehensible to the man on the street. I have wikilinked as much as I can but there are words such as "digenic" and "nonsyndromic" and phrases such as "the visual transduction cascade" which can't be linked and would have no obvious meaning to most people. Richerman ( talk) 15:13, 23 April 2008 (UTC)
I suggest to add the term rod-cone dystrophy. It is used to distinguish Retinitis pigmentosa (rod-cone dystrophy) from inversa retinitis pigmentosa (cone-rod dystrophy) —Preceding unsigned comment added by 151.53.240.221 ( talk) 07:15, 20 May 2008 (UTC)
The intro is poorly written. Would anyone like to make changes or shall I take care of it?
AriaNo11 ( talk) 18:28, 19 June 2010 (UTC)
Any objections to moving the list of notable RP sufferers to a separate article ? Rod57 ( talk) 14:00, 25 June 2010 (UTC)
I could not verify that Kevin James has RP. I found one article mentioning that *his sister* has it. — Preceding
unsigned comment added by
Rssnkgp02 (
talk •
contribs) 02:14, 4 January 2011 (UTC)
Surely we need a section on treatment or management of RP - or at least say there are no treatments if that's the case. Rod57 ( talk) 14:00, 25 June 2010 (UTC)
There is a spoken file of old version of this article.
Is it lost or it was intentionally removed? I don't know. -- Andrew Krizhanovsky ( talk) 17:50, 10 August 2011 (UTC)
A child displaying signs of RP may fall often, hit their heads on overhanging furniture or play structures, lose themselves in a darkened room or have difficulty locating objects. These signs are due to the reduced night vision and tunnel vision associated with RP. 198.103.167.20 ( talk) 17:26, 18 October 2011 (UTC)
3 of my siblings have retinitis pigmentosa. . .they would object to the language "suffering with". They do not "suffer" because of RP, they adapt and thrive. Better language would be "people who have rp", "people experience RP", "people with rp".
Thanks for considering making the language more empowering and less disabling.
Colleen Erb — Preceding unsigned comment added by 205.196.128.3 ( talk) 14:57, 9 June 2013 (UTC)
Hi all,
After spending a bit of time studying the manifestation and treatments available for retinitis pigmentosa, I feel like it is important to strengthen and substantiate the "treatment" section of the wikipedia article. While it currently focuses primarily on Argus II and vitamin treatments, information regarding additional therapies (such as induced pluripotent stem cell transplantation or embryonic stem cell transplantation) and alternative prosthetic devices would solidify the "Treatment" section. I am currently researching and gathering data regarding this topic, and hope to contribute significant information to strengthen the overall content of the article.
Meanwhile, here is an article that I find interesting regarding RP therapies and treatments. http://www.nature.com/news/curing-blindness-vision-quest-1.15875?WT.ec_id=NATURE-20140911 [1]
This article was the subject of an educational assignment in Spring 2015. Further details were available on the "Education Program:Saint Louis University/SLU Biology 496 (Spring 2015)" page, which is now unavailable on the wiki. |
Here are some sources that I will be using during my research. I will continue to add possible sources and develop a more structured bibliography. Please feel free to recommend any relevant sources and evaluate my list of article options that I have compiled thus far.
PubMed article, Retinitis Pigmentosa" [2]
PubMed article providing an overview of disease presentation, pathology, and treatment [3]
Orphanet Journal of Rare Diseases [4]
Transplanting retinal pigment epithelium [5]
Therapeutic techniques - prosthetic devices, gene therapy, stem cell [6]
Mechanism of the rod degeneration and cell death [7] [8]
Thanks!
Carolynslu ( talk) 19:51, 28 February 2015 (UTC)
References
Here are a list of some my project goals while reconstructing the Retinitis Pigmentosa Wikipedia article
I will continue to update this list of goals as my research continues!
Carolynslu ( talk) 02:54, 10 March 2015 (UTC)
As a part of assignment I will be peer-reviewing an article used in the article about [[Retinitis pigmentosa]. The article in question is a comprehensive review about Retinitis pigmentosa and covers a lot of the more basic and some advanced information about the disorder. The article can be found here: [2]
Overall, the review done in this article for the disorder is very well written. It encompasses a lot of the basic facts that are required to understand Retinitis pigmentosa. In addition, it goes into a lot of detail about the causes and pathology of retinitis pigmentosa.
Overall, the article is very critical in the future development of the Retinitis Pigmentosa page. It has a lot of great information that is used. Good choice is picking such a comprehensive review article.
Hey Carolyn, your article looks really well done. I am really enjoying all the information you have gathered, pictures, and tables that you were able to find. They contribute really well to the overall flow and ease of information.
Again really well done, the article really has taken a good shape for the final form. VarunS93 ( talk) 23:07, 27 April 2015 (UTC) VarunS93 ( talk) 22:59, 27 April 2015 (UTC) VarunS93 ( talk) 20:44, 8 April 2015 (UTC)
— Preceding unsigned comment added by VarunS93 ( talk • contribs) 20:34, 8 April 2015 (UTC)
Lately there's been a lot of research on the photopigment melanopsin (peak sensitivity 480 mn). We have it on our ipRGCs (Intrinsically photosensitive retinal ganglion cells). (It's also in our skin and brains.) In one study, two elderly Japanese people who were profoundly blind with Retinitis pigmentosa were found to have pupil response that peaked at 480 nm. There is also indication that such people can sense the presence or absence of light. In blind mice with no rods or cones, they've been able to amp up the Melanopsin and get them to pass simple vision tests. Zyxwv99 ( talk) 21:09, 18 October 2015 (UTC)
http://articles.latimes.com/1993-02-28/news/mn-231_1_retinitis-pigmentosa
Notable case - perhaps. (also mentioned, briefly, in http://history.nasa.gov/sp482.pdf on page 51 of the pdf, p46 of the printed book - NASA SP-482 -THE IMPACT OF SCIENCE ON SOCIETY - James Burke - Jules Bergman - Isaac Asimov ). 213.222.172.165 ( talk) 23:15, 5 July 2016 (UTC).
Retinitis pigmentosa has an array of identifyingCite error: There are <ref>
tags on this page without content in them (see the
help page). features. These include night blindness, a decrease in peripheral vision, narrowing of the retinal vessels, and the movement of pigment from disrupted retinal pigment epithelium into the retina, forming clumps. These darker clumps of pigment are the hallmark of the disorder.
Mp214 (
talk) 17:59, 25 April 2018 (UTC)
This just arrived by way of CNN: Blind man has sight partially restored after 40 years. The CNN article reference a newly published paper from Nature Medicine journal: Partial recovery of visual function in a blind patient after optogenetic therapy.
Jeffrey Walton ( talk) 04:00, 4 June 2021 (UTC)