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![]() | Ideal sources for Wikipedia's health content are defined in the guideline
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![]() | The contents of the Treatment of renal cell carcinoma page were merged into Renal cell carcinoma on March 2016. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
I'm not sure people reading this article would want to know what "vast improvement" means, but if I were reading it, I'd probably guess that "vast improvement" means possibly living long enough to die of some other cause -- say, at least a few years. I think what we are talking about here is a treatment effect measured in weeks, not months, and certainly not years. I'm ambivalent about the value of truthfulness here -- but isn't an encyclopedia meant to be be the straight truth?
Anybody in favor of including the detail of how many weeks of disease free progression we are really talking about compared to placebo?
Tombadog ( talk) 23:51, 29 December 2007 (UTC)
There's a NEJM review here. Anyone interested? JFW | T@lk 23:27, 11 December 2005 (UTC)
I don't think the search term "kidney cancer" should necessarily redirect here, seeing as Nephroblastoma/Wilm's tumor is another fairly common kidney cancer (although it is usally seen in children rather than adults. There are also rhabdoid kidney tumors. Seeing as there are different kinds of kidney cancer, I think the redirect should be changed, perhaps to a disambiguation page. Dylan Slade 01:06, 19 February 2007 (UTC)
Agreed. deBronkart 02:50, 28 October 2007 (UTC)
The revision "11:25, 5 March 2007 71.216.118.181" removed the word "gross" from the phrase "gross examination". I restored the word because its absence significantly alters the meaning of the sentence. Specifically, gross examination refers to a macroscopic examination, i.e. with the naked eye, as opposed to, for example, microscopic examination or chemical analysis. [1] PHaze 23:51, 6 March 2007 (UTC)
I submit this with hesitation because I'm new and I know it's important not to behave cluelessly here. But, I'm a patient with this cancer and I want to contribute, so here I am. Tell me where to go to learn more about editing, if you want.
How do I properly edit the article to handle these items?
1. Furhman is actually Fuhrman (and ought to have its own article). (I figured out the typo myself.)
2. A lot of widely known stats about RCC are obsolete. The ones shown here appear more modern, but they ought to cite their source. How do I add an "attribution needed" mark? --Update: Thanks to Derwig for the tip.
deBronkart 20:13, 27 October 2007 (UTC)
If anyone is looking, the Diagnosis section of this article was lifted (plagiarized) word-for-word from a blog. No sources are given either in the blog or in the article, and this information is thus unverified. Since this is a medical article visited by patients, it is CRITICAL that this information be verified with sources or removed. Lives may be at stake. I do not feel qualified to change this information, but if someone here is, please fix this. —Preceding unsigned comment added by Dragonfire2384 ( talk • contribs) 23:45, 11 November 2009 (UTC) please rewrite the diagnosis section as soon as possible.it was indeed copied word-for word,and it's tone is not appropriate for wikipedia.it is also overly technical.as i am a reletive newcomber to wikipedia,i do not think that i should rewrite the article myself,but if there is someone on wikipedia who has extensive experience writing articlke and is knows alot about RCC,please rewrite this article.
given that 60-70% of rcc pateints experience metastasis,i thought a section devoted entirely to metastatic renal cell cancer was war rented,and added it this morning.i have info on the treatment and symptoms of metastatic renal cell carcinoma,and will be adding more information soon. 24.97.164.250 ( talk) 22:06, 16 December 2009
agree the new section on metastatic renal cell carcinoma is warrented,but why did you not cite any references? 169.244.148.235 ( talk) 21:28, 19 December 2009 (UTC)
that section of the article is a complete mess.While i do not think should not be deleted,it needs cleanup and attention from an expert very badly.i will post the {{ expert}} template there shortly. Immunize ( talk) 16:18, 12 January 2010 (UTC)
The section should probably have been a stub for metastatic renal cell carcinoma then we could remove duplications from the main article. Rod57 ( talk) 07:36, 27 November 2010 (UTC)
doi: 10.1016/S0140-6736(09)61921-8 addition of anti-IL2 has no appreciable impact on survival in addition to interferon in those with advanced metastatic disease. JFW | T@lk 10:08, 21 February 2010 (UTC)
The pathology section mentions that these tumors can cause an increase in erythropoietin production, leading to polycythemia. Actually, polycythemia is mentioned in the symptoms section; it's referred to as erythrocytosis (synonymous, redirects to polycythemia) in the path section.
The symptoms section says that they can result in a decrease of epo production, resulting in anemia.
None of these appear to have direct citations. Can we clarify that both of these can occur from RCC?
-- Spiffulent ( talk) 17:46, 24 May 2010 (UTC)
I don't see the point of having a separate article with mainly duplicate information already found in the main article. The main article is not of a length justifying a split. Mikael Häggström ( talk) 10:23, 21 November 2010 (UTC)
Rencarex for ccRCC says mAb girentuximab is in phase III trial for clear cell renal cell carcinoma. Rod57 ( talk) 23:12, 2 May 2011 (UTC)
There are many confusions between "renal cell carcinoma" that is indeed a very heterogenous tumoral group and " clear cell renal cell carcinoma". It is better to separate each tumoral entity. patho ( talk) 16:08, 17 February 2014 (UTC)
I think the tables could do with collapsing; as they may make the article a little too overwhelming for the lay people. Thoughts? Fuse809 ( talk) 09:47, 8 March 2014 (UTC)
doi:10.1016/S0140-6736(15)00046-X JFW | T@lk 14:54, 26 February 2016 (UTC)
Weighing the Options for Progressive Renal Cancer says "Both cabozantinib and nivolumab were superior to everolimus, regardless of the type of disease. After a patient with RCC progresses on a TKI, the National Comprehensive Cancer Network guidelines give four drugs a category 1 recommendation: cabozantinib (Cometriq, Exelixis), nivolumab (Opdivo, Bristol-Myers Squibb), everolimus (Afinitor, Novartis) and axitinib (Inlyta, Pfizer)." - Rod57 ( talk) 02:43, 4 March 2016 (UTC)
Review of systemic treatment for metastatic disease doi: 10.1056/NEJMra1601333 JFW | T@lk 23:09, 25 January 2017 (UTC)
Added info from a Cochrane review comparing targeted therapy and immunotherapy drugs -- Gsom12812 ( talk) 22:40, 28 February 2021 (UTC)
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Renal cell carcinoma.
|
![]() | The contents of the Treatment of renal cell carcinoma page were merged into Renal cell carcinoma on March 2016. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
I'm not sure people reading this article would want to know what "vast improvement" means, but if I were reading it, I'd probably guess that "vast improvement" means possibly living long enough to die of some other cause -- say, at least a few years. I think what we are talking about here is a treatment effect measured in weeks, not months, and certainly not years. I'm ambivalent about the value of truthfulness here -- but isn't an encyclopedia meant to be be the straight truth?
Anybody in favor of including the detail of how many weeks of disease free progression we are really talking about compared to placebo?
Tombadog ( talk) 23:51, 29 December 2007 (UTC)
There's a NEJM review here. Anyone interested? JFW | T@lk 23:27, 11 December 2005 (UTC)
I don't think the search term "kidney cancer" should necessarily redirect here, seeing as Nephroblastoma/Wilm's tumor is another fairly common kidney cancer (although it is usally seen in children rather than adults. There are also rhabdoid kidney tumors. Seeing as there are different kinds of kidney cancer, I think the redirect should be changed, perhaps to a disambiguation page. Dylan Slade 01:06, 19 February 2007 (UTC)
Agreed. deBronkart 02:50, 28 October 2007 (UTC)
The revision "11:25, 5 March 2007 71.216.118.181" removed the word "gross" from the phrase "gross examination". I restored the word because its absence significantly alters the meaning of the sentence. Specifically, gross examination refers to a macroscopic examination, i.e. with the naked eye, as opposed to, for example, microscopic examination or chemical analysis. [1] PHaze 23:51, 6 March 2007 (UTC)
I submit this with hesitation because I'm new and I know it's important not to behave cluelessly here. But, I'm a patient with this cancer and I want to contribute, so here I am. Tell me where to go to learn more about editing, if you want.
How do I properly edit the article to handle these items?
1. Furhman is actually Fuhrman (and ought to have its own article). (I figured out the typo myself.)
2. A lot of widely known stats about RCC are obsolete. The ones shown here appear more modern, but they ought to cite their source. How do I add an "attribution needed" mark? --Update: Thanks to Derwig for the tip.
deBronkart 20:13, 27 October 2007 (UTC)
If anyone is looking, the Diagnosis section of this article was lifted (plagiarized) word-for-word from a blog. No sources are given either in the blog or in the article, and this information is thus unverified. Since this is a medical article visited by patients, it is CRITICAL that this information be verified with sources or removed. Lives may be at stake. I do not feel qualified to change this information, but if someone here is, please fix this. —Preceding unsigned comment added by Dragonfire2384 ( talk • contribs) 23:45, 11 November 2009 (UTC) please rewrite the diagnosis section as soon as possible.it was indeed copied word-for word,and it's tone is not appropriate for wikipedia.it is also overly technical.as i am a reletive newcomber to wikipedia,i do not think that i should rewrite the article myself,but if there is someone on wikipedia who has extensive experience writing articlke and is knows alot about RCC,please rewrite this article.
given that 60-70% of rcc pateints experience metastasis,i thought a section devoted entirely to metastatic renal cell cancer was war rented,and added it this morning.i have info on the treatment and symptoms of metastatic renal cell carcinoma,and will be adding more information soon. 24.97.164.250 ( talk) 22:06, 16 December 2009
agree the new section on metastatic renal cell carcinoma is warrented,but why did you not cite any references? 169.244.148.235 ( talk) 21:28, 19 December 2009 (UTC)
that section of the article is a complete mess.While i do not think should not be deleted,it needs cleanup and attention from an expert very badly.i will post the {{ expert}} template there shortly. Immunize ( talk) 16:18, 12 January 2010 (UTC)
The section should probably have been a stub for metastatic renal cell carcinoma then we could remove duplications from the main article. Rod57 ( talk) 07:36, 27 November 2010 (UTC)
doi: 10.1016/S0140-6736(09)61921-8 addition of anti-IL2 has no appreciable impact on survival in addition to interferon in those with advanced metastatic disease. JFW | T@lk 10:08, 21 February 2010 (UTC)
The pathology section mentions that these tumors can cause an increase in erythropoietin production, leading to polycythemia. Actually, polycythemia is mentioned in the symptoms section; it's referred to as erythrocytosis (synonymous, redirects to polycythemia) in the path section.
The symptoms section says that they can result in a decrease of epo production, resulting in anemia.
None of these appear to have direct citations. Can we clarify that both of these can occur from RCC?
-- Spiffulent ( talk) 17:46, 24 May 2010 (UTC)
I don't see the point of having a separate article with mainly duplicate information already found in the main article. The main article is not of a length justifying a split. Mikael Häggström ( talk) 10:23, 21 November 2010 (UTC)
Rencarex for ccRCC says mAb girentuximab is in phase III trial for clear cell renal cell carcinoma. Rod57 ( talk) 23:12, 2 May 2011 (UTC)
There are many confusions between "renal cell carcinoma" that is indeed a very heterogenous tumoral group and " clear cell renal cell carcinoma". It is better to separate each tumoral entity. patho ( talk) 16:08, 17 February 2014 (UTC)
I think the tables could do with collapsing; as they may make the article a little too overwhelming for the lay people. Thoughts? Fuse809 ( talk) 09:47, 8 March 2014 (UTC)
doi:10.1016/S0140-6736(15)00046-X JFW | T@lk 14:54, 26 February 2016 (UTC)
Weighing the Options for Progressive Renal Cancer says "Both cabozantinib and nivolumab were superior to everolimus, regardless of the type of disease. After a patient with RCC progresses on a TKI, the National Comprehensive Cancer Network guidelines give four drugs a category 1 recommendation: cabozantinib (Cometriq, Exelixis), nivolumab (Opdivo, Bristol-Myers Squibb), everolimus (Afinitor, Novartis) and axitinib (Inlyta, Pfizer)." - Rod57 ( talk) 02:43, 4 March 2016 (UTC)
Review of systemic treatment for metastatic disease doi: 10.1056/NEJMra1601333 JFW | T@lk 23:09, 25 January 2017 (UTC)
Added info from a Cochrane review comparing targeted therapy and immunotherapy drugs -- Gsom12812 ( talk) 22:40, 28 February 2021 (UTC)