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Hi. I just wondered if people who suffer from Progeria's hormone cycle is the same as people not suffering from it. For example, do progeria girls' menstrual cycles start prematurely?
Jchillerup 21:17, 13 July 2005 (UTC)
To avoid confusion, it would probably be a good idea to move this page to Hutchinson-Gilford progeria syndrome, the name that is usually used in medical literature, and give a more general overview of progeria and different syndromes here. -- WS 23:47, 13 February 2006 (UTC)
The first part of the article states: "Unlike most other "accelerated aging diseases" (like Werner's syndrome), progeria is not caused by defective DNA repair."
Under cause, the article then states: "New evidence suggests that, as in other aging syndromes, the cause of HGPS is due to a defect in the DNA repair via the homologous recombination pathway."
It cannot be both. Though the first part of the article seems definitive when it says that HPGS is not caused by defective DNA repair. —Preceding unsigned comment added by 71.135.44.36 ( talk) 20:04, 17:07, 7 March 2006 (UTC)
A recent report (Recapitulation of premature aging with iPSCs from Hutchinson-Gilford progeria syndrome, Nature Vol. 472 page 221) demonstrates that progerin, the deletion splicing mutant of lamin A that accumulates in HGPS (and to a lesser extent in normal cells), binds to and decreases the level of DNA-dependent protein kinase, which is required for nonhomologous end joining, a form of double-strand break DNA repair (which is NOT the homologous recombination pathway, which is the OTHER form of DSB repair). Since a lack of DNAPK has been shown to produce accelerated aging in mice this is almost certainly the molecular basis of HGPS (and may even contribute significantly to normal aging). 69.72.27.64 ( talk) 08:36, 23 May 2011 (UTC)
I need some pictures for a visual aid... other then people who have the disease. That is all there is on google images and all the sites I've been to. —Preceding unsigned comment added by 68.37.51.204 ( talk) 03:03, 5 April 2006 (UTC)
Found some pictures
I had to have pictures for my project, so I thought this might help. If someone wants to move either or these into the arcticle thats good, but I don't know enough to do it myself. http://img125.imageshack.us/img125/1314/progeriacells0yi.jpg http://img125.imageshack.us/img125/1717/progeria6ay.jpg
The one in spanish I used a free Spanish to English translator on. Sorry for any inaccuracies! The one with the picture of the child with progeria: The first cell is a normal healthy cell and the second is a cell from someone with progeria. — Preceding unsigned comment added by 68.37.51.204 ( talk)
I added a picture of John Tucket, after reading an interview with him when he was in 8th grade at school.
Emperor Jackal 19:41, 9 May 2007 (UTC)
I added internal Wiki-links for the terms 'CAAX box' and 'C-termius' under the Cause section. It seems to me that basic terms like this should be defined somewhere, as should other terms for general DNA structures such as 'forkhead box', 'winged helix' - I assume these are general structures (I am not a geneticist) The referencing articles do not exist yet. - Jim Witte—The preceding unsigned comment was added by 216.9.143.221 ( talk) 17:37, 24 January 2007 (UTC).
FYI, I removed the first sentence of the symptoms section - i.e. "Symptoms generally begin appearing around 18-24 months of age.". Progeria diagnosises have actually occurred within the first 5 months of life and certain symptoms can be witnessed at birth or shortly thereafter (i.e. FTT and a specific skin abnormalities).
Want to modify the list to include other common symptoms (i.e. lack of subcutaneous fat causing prominent veins on the head, atrophy of lower legs etc.)
Yelirmac 03:00, 17 June 2007 (UTC)
"Currently, there are 51 known cases in the world."
"Around 100 cases have been identified since then."
Am I missing something? -- 68.100.13.86 18:16, 27 July 2007 (UTC)
The article speaks of a few million reported cases, but later, says only about 100 cases have been identified. Is the one sentence referring to general accelerated aging diseases, and the other sentence referring only to HGPS? That's the only explanation I can think of. -- Iritscen ( talk) 15:09, 4 January 2008 (UTC)
In the first paragraph it said 1 in 8 million children are born with this condition, but in the Epidemiology section it said there were about 100 cases documented in history. I put both of these statistics in my essay, and my professor told me there are about 134,000,000 live births each year, which would mean there are 16 million children born with this condition. —Preceding unsigned comment added by 75.161.148.200 ( talk) 22:41, 15 July 2009 (UTC)
There's a lot of jargon in the overview section, particular the paragraph that starts with "Prelamin A...". It's unreadable to the layman. So I've tagged it in hopes of a cleanup or revision. ( Darthveda ( talk) 13:19, 6 February 2008 (UTC))
Do we really want to include the names of living people with this condition? If you were a child with this condition, would you necessarily want the entire world to know your family's name, town, and medical history? I'm inclined to remove the family names and leave just a general location (region or country). WhatamIdoing ( talk) 21:05, 31 May 2008 (UTC)
Clearly the term comes from Ancient Greek (as most medical terms do) however could we get the exact derivation in the first line of the article. From my rough knowledge of Ancient Greek, it should read something along the lines of:
Progeria (from Greek[link to Greek language] Προγερια - Προς, pros, towards; and Γερον, geron, age.) refers specifically to... etc.
This needs to be checked. I am not sure if I have got the word broken down correctly (i.e. it might be geria or geron or some other form) and I am also not sure about my translations, I have a funny feeling geron might mean old man instead of just old age. So if someone with a little more Ancient Greek knowledge could put it in that would be helpful.
Fildon 15:18, 8th of August 2008 (GMT)
The popular culture section seems to attract trivial entries from popular entertainment. Furthermore, in almost every case, the 'progeria' is not actually progeria; it's an invented syndrome with remarkably little connection to the real thing. Could we perhaps turn this into a paragraph about the way that progeria is misrepresented in popular culture? Does anyone know of any sources that we could use to support it? WhatamIdoing ( talk) 01:42, 14 November 2008 (UTC)
I'm not sure where this information might go in the article, but Rabbi Harold Kushner's son, Aaron, died of progeria in 1977 at age 14. Kushner is the author of the book "When Bad Things Happen to Good People". 98.229.226.9 ( talk) 04:36, 2 December 2008 (UTC) Bob Hynes, 1-Dec-2008
Someone please add something about S1E2 concept of Fringe on popular culture section! —Preceding unsigned comment added by 91.99.165.139 ( talk) 12:27, 20 February 2010 (UTC)
I'd like some opinions on the changes in this diff. It's correct that there was a Bodyshock program about an Indian family with five children suffering from progeria - see [2], but there is also at least the family with two children at [3]. There may be a difference in terminology here, perhaps a confusion between Classical Hutchinson-Gilford Progeria and something else called progeria, such as Werner syndrome. I've read Bruce Korf's paper (reference 2 in the article) and it doesn't discuss families with more than one children suffering from progeria.
The latter link gives the number of living people with progeria as being between 35 and 45, and the anon has given the number as precisely 48 without giving a reference or updating the ref given.
It would appear that the anon's edit is insufficiently referenced, but it is not obviously incorrect. Perhaps it has some information previously missing from the article. I reverted it as being contrary to the sources a few days ago, but now that I've looked at it in more detail, I think perhaps our sources are incomplete.- gadfium 00:58, 21 January 2009 (UTC)
The navigation bar (is that what it is called?) at the bottom of the page classifies progeria as an endocrine disorder, but I can't see the link to hormones in what is essentially a genetic nuclear disorder.
Tanjx ( talk) 09:12, 28 September 2009 (UTC)
There is also a 'HINDI' movie based on this diesease by the name PAA (meaning 'father' in English). The lead role in the movie is played by legendary star of Hindi Cinema Amitabh Bachchan and his son Abhishek Bachchan. The female lead in the movie is played by Vidya Balan. —Preceding unsigned comment added by 202.79.203.43 ( talk) 07:28, 13 February 2010 (UTC)
The article contains this referenced statement: "Those born with progeria typically live about thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties." Since I don't have access to these articles, can someone double check them? In particular I am curious about the upper age limit for progeria survival. According to: http://www.progeriaresearch.org/about_progeria.html " Children with Progeria die of atherosclerosis (heart disease) at an average age of thirteen years (with a range of about 8 - 21 years). * Other progeroid syndromes include Werner's syndrome, also known as "adult progeria" which does not have an onset until the late teen years, with a life span into the 40's and 50's." Since this is in reference to 'other progeroid syndromes' like Werner's syndrome, the reference to people with progreria reaching their forties may be incorrect. The only reference I was able to find such a thing was the following article which I think most likely spells out that he had a teen-onset progeroid syndrome, not progeria: [I can't post the url here because it triggers a spam filter, but it's an associated content article that I was only able to see by looking up it's cache on google.] Centerone ( talk) 01:28, 11 March 2010 (UTC)
A progeria is a disease where the patient experiences some characteristics linked to aging quicker than normal. Hutchinson-Gilford should be a separate article because it is an example of a progeria. We should not confuse a progeria with HGS. This article should link to all the possible progerias: Hutchinson-Gilford Syndrome, Werner's Syndrome, and Downs Syndrome.
Cheers —Preceding unsigned comment added by 70.27.31.100 ( talk) 03:17, 12 November 2010 (UTC)
I encourage editors to watch out for these erroneous labels. Given that 1) the etiology of aging is unknown and 2) progeria does not fully resemble aging, these labels are very misleading despite their prevalent use.-- Xris0 ( talk) 21:26, 25 January 2011 (UTC)
In the introduction it says:
OK! let's get it consistent. It's important. Kids with this condition read Wikipedia, just like all the rest. This is the article that pops up first if you Google. So what is the expectancy? Is it "typically" early 20s or "rarely" 21? Amandajm ( talk) 15:03, 2 November 2011 (UTC)
HELP Hi Kids! I know maybe it sound ridiculous for all of you that are so clever and so informed about this awful disease, but I am consern about a BIG STUPID ARGUMENT in another knowledge area that maybe can be resolve with clarifying what is Progeria. Let me ask, What do you know about the starchild skull and, can it be a progerian kid skull, as the picture i upload on my website, shows? I want to clarify that is most possible to find a progerian kid skull than an et hibrid skull. Thanks a lot for your really awesome research. (http:tienesmiedoapensar.blogspot.com) — Preceding unsigned comment added by C ( talk • contribs) 06:28, 9 December 2011 (UTC)
Thanks for the advice, i will write at science forum, hate ufology, but i wonder if you can help me, as a fact i was trying to find a specialist in progeria that can help me to find similarities between this skull and the progerias (particulary their cc). You re right sorry for my mistake, Jean Bernstein
The introduction states, "Those born with progeria typically live to their mid teens and early twenties."
Then there is this sentence under the prognosis section: "As there is no known cure, few people with progeria exceed 13 years of age."
This is a vast discrepancy which ought to be fixed. Unfortunately I do not have access to all of the source material. I am also concerned about the wording of the latter of the two since the reference to it reads, "On average, they die at 13." To say few people exceed 13 is misleading.
--
Kmonkmon (
talk) 06:35, 19 July 2012 (UTC)
See http://www.progeriaresearch.org/first-ever-progeria-treatment.html
I appreciate that I could make the changes to the article, but I think it better done by someone with a far greater medical knowledge than myself, or at least by someone more familiar with this article. Consider this a head's up. fredgandt 21:41, 24 September 2012 (UTC)
The table at the begining of the "Cause" section states that in a normal cell "Prelamin A is not anchored to the nuclear rim", while in a cell affected by progeria "Progerin is anchored to the nuclear rim".
At the same time the text that follows the table states exactly the opposite: in a normal cell "...permanently affixes the protein (prelamin A) to the nuclear rim...", while in the affected cell "...abnormal protein, referred to as progerin, cannot be affixed to the nuclear rim..." — Preceding unsigned comment added by Calligrapher ( talk • contribs) 17:06, 25 September 2012 (UTC)
The captions, which have already been marked as being too long, are copied wholesale from [4]. This is a clearly copyright violation. I've removed the large image which seems to be based entirely on this research and which will need a new caption, if it is added back to the article. I've trimmed the captions on the other two images. -- Hazhk Talk to me 20:10, 25 November 2012 (UTC)
I have not found "nuclear rim" defined anywhere in Wikipedia. I found a definition at the following website which describes multiple sclerosis.
< http://www.biologyreference.com/Mo-Nu/Nuclear-Transport.html>
A nuclear rim is not the rim of the nucleus, but the inner (nuclear) end of a nuclear pore. I do not know whether it is structurally or compositionally different from the rest of the pore.
The article states that "The farnesyl group allows prelamin A to attach temporarily to the nuclear rim". I have severe doubts about this, but i do not know the relevant literature well enough to adequately research it. It is obvious that a good source needs to be cited.
I suspect that the writer mistook the inside of the nuclear envelope for the nuclear rim. It is also possible that the writer confused the nuclear lamina with the nuclear basket. The latter is attached to the nuclear rim. 76.93.209.228 ( talk) 23:39, 26 December 2015 (UTC)
So I was reading about an "immortal jellyfish" after I read about progeria, and I was just thinking that for a cure they could just use special hormones or something from the Turritopsis nutricula (the immortal jellyfish). It would kind of make sense in a way… Byu cougs ( talk) 05:13, 7 April 2017 (UTC)
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Hello
I was a bit surprised by the sentence "Progeria, also known as "Benjamin Button Disease", and wonder if Progeria is truly refered to as such or of it might be the editor's personal opinion?
After all, the character Benjamin Button was born looking aged but then became younger and younger looking, not older looking, which on the other hand individuals with Progeria do.
Honestly, the only time I had hitherto seen that term (Benjamin Button) is in regards of individuals that appear to not age. For instance the following, who is described as "The Benjamin Button of Korea";
https://www.koreaboo.com/stories/30-year-old-korean-man-rare-condition-makes-look-like-child/
Or this case, where a skincare company is named Benton Inc.; a contraction of Brad Pitt's character Benjamin Button, who the founder described as "a man who ages in reverse", which, as we know, is true about his character.
So, is there truly any support for the claim in question, that Progeria is also known as Benjamin Button Disease?
Thank you. Okama-San ( talk) 16:59, 10 September 2019 (UTC)
I believe the YouTuber Justin Tsimbidis (used to be Tsimfuckis) has progeria as well. He is currently 28 years old. Doris Mae1997 ( talk) 04:27, 3 October 2021 (UTC)
The lede says "Patients born with progeria typically live to an age of mid-teens to early twenties" but under Prognosis it says "few people with progeria exceed 13 years of age", and this is in the summary box at the top as well. This doesn't seem consistent.
It also says "Progeroid syndromes are a group of diseases that causes individuals to age faster than usual", but the page on Progeroid syndromes says that they mimic physiological aging, which doesn't seem like quite the same thing.
Can someone comment on this? I have no subject knowledge here. RapturousRatling ( talk) 20:13, 28 January 2022 (UTC)
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Hi. I just wondered if people who suffer from Progeria's hormone cycle is the same as people not suffering from it. For example, do progeria girls' menstrual cycles start prematurely?
Jchillerup 21:17, 13 July 2005 (UTC)
To avoid confusion, it would probably be a good idea to move this page to Hutchinson-Gilford progeria syndrome, the name that is usually used in medical literature, and give a more general overview of progeria and different syndromes here. -- WS 23:47, 13 February 2006 (UTC)
The first part of the article states: "Unlike most other "accelerated aging diseases" (like Werner's syndrome), progeria is not caused by defective DNA repair."
Under cause, the article then states: "New evidence suggests that, as in other aging syndromes, the cause of HGPS is due to a defect in the DNA repair via the homologous recombination pathway."
It cannot be both. Though the first part of the article seems definitive when it says that HPGS is not caused by defective DNA repair. —Preceding unsigned comment added by 71.135.44.36 ( talk) 20:04, 17:07, 7 March 2006 (UTC)
A recent report (Recapitulation of premature aging with iPSCs from Hutchinson-Gilford progeria syndrome, Nature Vol. 472 page 221) demonstrates that progerin, the deletion splicing mutant of lamin A that accumulates in HGPS (and to a lesser extent in normal cells), binds to and decreases the level of DNA-dependent protein kinase, which is required for nonhomologous end joining, a form of double-strand break DNA repair (which is NOT the homologous recombination pathway, which is the OTHER form of DSB repair). Since a lack of DNAPK has been shown to produce accelerated aging in mice this is almost certainly the molecular basis of HGPS (and may even contribute significantly to normal aging). 69.72.27.64 ( talk) 08:36, 23 May 2011 (UTC)
I need some pictures for a visual aid... other then people who have the disease. That is all there is on google images and all the sites I've been to. —Preceding unsigned comment added by 68.37.51.204 ( talk) 03:03, 5 April 2006 (UTC)
Found some pictures
I had to have pictures for my project, so I thought this might help. If someone wants to move either or these into the arcticle thats good, but I don't know enough to do it myself. http://img125.imageshack.us/img125/1314/progeriacells0yi.jpg http://img125.imageshack.us/img125/1717/progeria6ay.jpg
The one in spanish I used a free Spanish to English translator on. Sorry for any inaccuracies! The one with the picture of the child with progeria: The first cell is a normal healthy cell and the second is a cell from someone with progeria. — Preceding unsigned comment added by 68.37.51.204 ( talk)
I added a picture of John Tucket, after reading an interview with him when he was in 8th grade at school.
Emperor Jackal 19:41, 9 May 2007 (UTC)
I added internal Wiki-links for the terms 'CAAX box' and 'C-termius' under the Cause section. It seems to me that basic terms like this should be defined somewhere, as should other terms for general DNA structures such as 'forkhead box', 'winged helix' - I assume these are general structures (I am not a geneticist) The referencing articles do not exist yet. - Jim Witte—The preceding unsigned comment was added by 216.9.143.221 ( talk) 17:37, 24 January 2007 (UTC).
FYI, I removed the first sentence of the symptoms section - i.e. "Symptoms generally begin appearing around 18-24 months of age.". Progeria diagnosises have actually occurred within the first 5 months of life and certain symptoms can be witnessed at birth or shortly thereafter (i.e. FTT and a specific skin abnormalities).
Want to modify the list to include other common symptoms (i.e. lack of subcutaneous fat causing prominent veins on the head, atrophy of lower legs etc.)
Yelirmac 03:00, 17 June 2007 (UTC)
"Currently, there are 51 known cases in the world."
"Around 100 cases have been identified since then."
Am I missing something? -- 68.100.13.86 18:16, 27 July 2007 (UTC)
The article speaks of a few million reported cases, but later, says only about 100 cases have been identified. Is the one sentence referring to general accelerated aging diseases, and the other sentence referring only to HGPS? That's the only explanation I can think of. -- Iritscen ( talk) 15:09, 4 January 2008 (UTC)
In the first paragraph it said 1 in 8 million children are born with this condition, but in the Epidemiology section it said there were about 100 cases documented in history. I put both of these statistics in my essay, and my professor told me there are about 134,000,000 live births each year, which would mean there are 16 million children born with this condition. —Preceding unsigned comment added by 75.161.148.200 ( talk) 22:41, 15 July 2009 (UTC)
There's a lot of jargon in the overview section, particular the paragraph that starts with "Prelamin A...". It's unreadable to the layman. So I've tagged it in hopes of a cleanup or revision. ( Darthveda ( talk) 13:19, 6 February 2008 (UTC))
Do we really want to include the names of living people with this condition? If you were a child with this condition, would you necessarily want the entire world to know your family's name, town, and medical history? I'm inclined to remove the family names and leave just a general location (region or country). WhatamIdoing ( talk) 21:05, 31 May 2008 (UTC)
Clearly the term comes from Ancient Greek (as most medical terms do) however could we get the exact derivation in the first line of the article. From my rough knowledge of Ancient Greek, it should read something along the lines of:
Progeria (from Greek[link to Greek language] Προγερια - Προς, pros, towards; and Γερον, geron, age.) refers specifically to... etc.
This needs to be checked. I am not sure if I have got the word broken down correctly (i.e. it might be geria or geron or some other form) and I am also not sure about my translations, I have a funny feeling geron might mean old man instead of just old age. So if someone with a little more Ancient Greek knowledge could put it in that would be helpful.
Fildon 15:18, 8th of August 2008 (GMT)
The popular culture section seems to attract trivial entries from popular entertainment. Furthermore, in almost every case, the 'progeria' is not actually progeria; it's an invented syndrome with remarkably little connection to the real thing. Could we perhaps turn this into a paragraph about the way that progeria is misrepresented in popular culture? Does anyone know of any sources that we could use to support it? WhatamIdoing ( talk) 01:42, 14 November 2008 (UTC)
I'm not sure where this information might go in the article, but Rabbi Harold Kushner's son, Aaron, died of progeria in 1977 at age 14. Kushner is the author of the book "When Bad Things Happen to Good People". 98.229.226.9 ( talk) 04:36, 2 December 2008 (UTC) Bob Hynes, 1-Dec-2008
Someone please add something about S1E2 concept of Fringe on popular culture section! —Preceding unsigned comment added by 91.99.165.139 ( talk) 12:27, 20 February 2010 (UTC)
I'd like some opinions on the changes in this diff. It's correct that there was a Bodyshock program about an Indian family with five children suffering from progeria - see [2], but there is also at least the family with two children at [3]. There may be a difference in terminology here, perhaps a confusion between Classical Hutchinson-Gilford Progeria and something else called progeria, such as Werner syndrome. I've read Bruce Korf's paper (reference 2 in the article) and it doesn't discuss families with more than one children suffering from progeria.
The latter link gives the number of living people with progeria as being between 35 and 45, and the anon has given the number as precisely 48 without giving a reference or updating the ref given.
It would appear that the anon's edit is insufficiently referenced, but it is not obviously incorrect. Perhaps it has some information previously missing from the article. I reverted it as being contrary to the sources a few days ago, but now that I've looked at it in more detail, I think perhaps our sources are incomplete.- gadfium 00:58, 21 January 2009 (UTC)
The navigation bar (is that what it is called?) at the bottom of the page classifies progeria as an endocrine disorder, but I can't see the link to hormones in what is essentially a genetic nuclear disorder.
Tanjx ( talk) 09:12, 28 September 2009 (UTC)
There is also a 'HINDI' movie based on this diesease by the name PAA (meaning 'father' in English). The lead role in the movie is played by legendary star of Hindi Cinema Amitabh Bachchan and his son Abhishek Bachchan. The female lead in the movie is played by Vidya Balan. —Preceding unsigned comment added by 202.79.203.43 ( talk) 07:28, 13 February 2010 (UTC)
The article contains this referenced statement: "Those born with progeria typically live about thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties." Since I don't have access to these articles, can someone double check them? In particular I am curious about the upper age limit for progeria survival. According to: http://www.progeriaresearch.org/about_progeria.html " Children with Progeria die of atherosclerosis (heart disease) at an average age of thirteen years (with a range of about 8 - 21 years). * Other progeroid syndromes include Werner's syndrome, also known as "adult progeria" which does not have an onset until the late teen years, with a life span into the 40's and 50's." Since this is in reference to 'other progeroid syndromes' like Werner's syndrome, the reference to people with progreria reaching their forties may be incorrect. The only reference I was able to find such a thing was the following article which I think most likely spells out that he had a teen-onset progeroid syndrome, not progeria: [I can't post the url here because it triggers a spam filter, but it's an associated content article that I was only able to see by looking up it's cache on google.] Centerone ( talk) 01:28, 11 March 2010 (UTC)
A progeria is a disease where the patient experiences some characteristics linked to aging quicker than normal. Hutchinson-Gilford should be a separate article because it is an example of a progeria. We should not confuse a progeria with HGS. This article should link to all the possible progerias: Hutchinson-Gilford Syndrome, Werner's Syndrome, and Downs Syndrome.
Cheers —Preceding unsigned comment added by 70.27.31.100 ( talk) 03:17, 12 November 2010 (UTC)
I encourage editors to watch out for these erroneous labels. Given that 1) the etiology of aging is unknown and 2) progeria does not fully resemble aging, these labels are very misleading despite their prevalent use.-- Xris0 ( talk) 21:26, 25 January 2011 (UTC)
In the introduction it says:
OK! let's get it consistent. It's important. Kids with this condition read Wikipedia, just like all the rest. This is the article that pops up first if you Google. So what is the expectancy? Is it "typically" early 20s or "rarely" 21? Amandajm ( talk) 15:03, 2 November 2011 (UTC)
HELP Hi Kids! I know maybe it sound ridiculous for all of you that are so clever and so informed about this awful disease, but I am consern about a BIG STUPID ARGUMENT in another knowledge area that maybe can be resolve with clarifying what is Progeria. Let me ask, What do you know about the starchild skull and, can it be a progerian kid skull, as the picture i upload on my website, shows? I want to clarify that is most possible to find a progerian kid skull than an et hibrid skull. Thanks a lot for your really awesome research. (http:tienesmiedoapensar.blogspot.com) — Preceding unsigned comment added by C ( talk • contribs) 06:28, 9 December 2011 (UTC)
Thanks for the advice, i will write at science forum, hate ufology, but i wonder if you can help me, as a fact i was trying to find a specialist in progeria that can help me to find similarities between this skull and the progerias (particulary their cc). You re right sorry for my mistake, Jean Bernstein
The introduction states, "Those born with progeria typically live to their mid teens and early twenties."
Then there is this sentence under the prognosis section: "As there is no known cure, few people with progeria exceed 13 years of age."
This is a vast discrepancy which ought to be fixed. Unfortunately I do not have access to all of the source material. I am also concerned about the wording of the latter of the two since the reference to it reads, "On average, they die at 13." To say few people exceed 13 is misleading.
--
Kmonkmon (
talk) 06:35, 19 July 2012 (UTC)
See http://www.progeriaresearch.org/first-ever-progeria-treatment.html
I appreciate that I could make the changes to the article, but I think it better done by someone with a far greater medical knowledge than myself, or at least by someone more familiar with this article. Consider this a head's up. fredgandt 21:41, 24 September 2012 (UTC)
The table at the begining of the "Cause" section states that in a normal cell "Prelamin A is not anchored to the nuclear rim", while in a cell affected by progeria "Progerin is anchored to the nuclear rim".
At the same time the text that follows the table states exactly the opposite: in a normal cell "...permanently affixes the protein (prelamin A) to the nuclear rim...", while in the affected cell "...abnormal protein, referred to as progerin, cannot be affixed to the nuclear rim..." — Preceding unsigned comment added by Calligrapher ( talk • contribs) 17:06, 25 September 2012 (UTC)
The captions, which have already been marked as being too long, are copied wholesale from [4]. This is a clearly copyright violation. I've removed the large image which seems to be based entirely on this research and which will need a new caption, if it is added back to the article. I've trimmed the captions on the other two images. -- Hazhk Talk to me 20:10, 25 November 2012 (UTC)
I have not found "nuclear rim" defined anywhere in Wikipedia. I found a definition at the following website which describes multiple sclerosis.
< http://www.biologyreference.com/Mo-Nu/Nuclear-Transport.html>
A nuclear rim is not the rim of the nucleus, but the inner (nuclear) end of a nuclear pore. I do not know whether it is structurally or compositionally different from the rest of the pore.
The article states that "The farnesyl group allows prelamin A to attach temporarily to the nuclear rim". I have severe doubts about this, but i do not know the relevant literature well enough to adequately research it. It is obvious that a good source needs to be cited.
I suspect that the writer mistook the inside of the nuclear envelope for the nuclear rim. It is also possible that the writer confused the nuclear lamina with the nuclear basket. The latter is attached to the nuclear rim. 76.93.209.228 ( talk) 23:39, 26 December 2015 (UTC)
So I was reading about an "immortal jellyfish" after I read about progeria, and I was just thinking that for a cure they could just use special hormones or something from the Turritopsis nutricula (the immortal jellyfish). It would kind of make sense in a way… Byu cougs ( talk) 05:13, 7 April 2017 (UTC)
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Hello
I was a bit surprised by the sentence "Progeria, also known as "Benjamin Button Disease", and wonder if Progeria is truly refered to as such or of it might be the editor's personal opinion?
After all, the character Benjamin Button was born looking aged but then became younger and younger looking, not older looking, which on the other hand individuals with Progeria do.
Honestly, the only time I had hitherto seen that term (Benjamin Button) is in regards of individuals that appear to not age. For instance the following, who is described as "The Benjamin Button of Korea";
https://www.koreaboo.com/stories/30-year-old-korean-man-rare-condition-makes-look-like-child/
Or this case, where a skincare company is named Benton Inc.; a contraction of Brad Pitt's character Benjamin Button, who the founder described as "a man who ages in reverse", which, as we know, is true about his character.
So, is there truly any support for the claim in question, that Progeria is also known as Benjamin Button Disease?
Thank you. Okama-San ( talk) 16:59, 10 September 2019 (UTC)
I believe the YouTuber Justin Tsimbidis (used to be Tsimfuckis) has progeria as well. He is currently 28 years old. Doris Mae1997 ( talk) 04:27, 3 October 2021 (UTC)
The lede says "Patients born with progeria typically live to an age of mid-teens to early twenties" but under Prognosis it says "few people with progeria exceed 13 years of age", and this is in the summary box at the top as well. This doesn't seem consistent.
It also says "Progeroid syndromes are a group of diseases that causes individuals to age faster than usual", but the page on Progeroid syndromes says that they mimic physiological aging, which doesn't seem like quite the same thing.
Can someone comment on this? I have no subject knowledge here. RapturousRatling ( talk) 20:13, 28 January 2022 (UTC)