Pantothenic acid has been listed as one of the
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good article criteria. If you can improve it further,
please do so. If it no longer meets these criteria, you can
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There is a substantial body of literature that argues for Vitamin A reduction of acne, and there are also documented cases of high-dose B vitamins /causing/ acne: PMID 1834437 -- crl620 04:49, 5 May 2006 (UTC)
This article needs a complete rewrite. There is little information actually pertaining to Pantothenic acid, and lots of random junk about Dr. Lit-Hung Leung's research.
The 'study' performed by Dr. Lit-Hung Leung is extremely vague, published in a rediculous journal, and used commonly to sell B5 pills. The wiki page reads like an infomercial:
"Though this study was done in 1997, news did not spread...however, by word of mouth and eventually the internet, success stories have came in by the thousands..."
Here's the Leung article: PMID 7476595
It was published in the journal "Medical Hypotheses," which is described on their site as:
"Medical Hypotheses takes a deliberately different approach to peer review. Most contemporary practice tends to discriminate against radical ideas that conflict with current theory and practice. Medical Hypotheses will publish radical ideas, so long as they are coherent and clearly expressed. Furthermore, traditional peer review can oblige authors to distort their true views to satisfy referees, and so diminish authorial responsibility and accountability. In Medical Hypotheses, the authors' responsibility for the integrity, precision and accuracy of their work is paramount. The editor sees his role as a 'chooser', not a 'changer': choosing to publish what are judged to be the best papers from those submitted."
It looks like it's a journal without any review system.
Overall the data on the wiki are poorly cited and shallow.
The wiki lacks clear scientific evidence and has no sources (minus the link to "Coenzyme-A Technologies", a company selling skin products).
Legitimate and well regarded sources tend to disagree with some of the suggestions on the wiki page. The Pauling Institute describes pantothenic acid as helping to heal skin wounds, whereas the wiki article says that "Some users report that cuts heal very slowly."
Some key facts about pantothenic acid are missing, such as recent research, absorption as d-Calcium pantothenate, chemical structure, and metabolism. As Dan| says below, the information about metabolism and "part of Coenzyme-A" makes no sense. To answer Dan's question, the pantothenate is a CoA precursor: KEGG CoA Pathway
This article needs to be substantially rewritten.
Could someone please edit the painfully anthropomorphic "Insulin receptors are acylated with palmitic acid when they do not want to bind with insulin.[22] " Joel1947 ( talk) 18:25, 17 November 2015 (UTC)
Yes about the want to part, change it to acylation decreases binding of insulin to its receptors. FeritTuzer ( talk) 08:12, 26 January 2020 (UTC)
Regarding "It is also needed for proper and healthy growth of hair," is this here because certain shampoo companies say it's true or because it's actually the case? All I can find are suggestions that the use of this chemical in shampoos has no effect, eg [1] - 203.132.90.8 03:39, 4 Jun 2005 (UTC)
From personal experience: it is actually the case. 78.151.26.19 ( talk) 03:02, 28 October 2015 (UTC)
"Specifically, it is part of coenzyme-A (CoASH) in the metabolism and transfer of carbon chains."
Using B5 as a treatment to acne really does work. I myself have had amazing results from it, and I am also aware of several other successful cases. I can't agree or disagree with the reasoning behind it, but there is little point arguing its effectiveness having seen the dramatic changes it has had.
Journal of Cosmetics, Dermatological Sciences and Applications, 2012, 2, 132-135 doi:10.4236/jcdsa.2012.23026
www.scirp.org/fileOperation/downLoad.aspx?path=JCDSA20120300001_63880780.pdf predatory publisher&type=journal
"Conclusions: The results from this study indicated that the administration of a pantothenic based dietary supplement in healthy human adults with mild to moderate acne vulgaris is feasible, safe and well tolerated. Secondary analysis shows that administration of the study agent significantly reduced global facial blemishes. Further randomized, placebo-controlled trials are warranted."
thiamine—1.5 mg, riboflavin—1.7 mg, niacin—20 mg, pyridoxine—2 mg, folic acid—400 mgc, cyanoco-balamin—6 mcg, biotin—300 mcg, pantothenic acid— 2.2 g and L-carnitine—733.3 mg. : half of these a day
slightly relevant to the article
From the article, under disputed uses -> acne
"few if any dermatologists prescribe high-dose pantothenic acid."
Admittedly, few dermatologists (or any doctors, for that matter) prescribe pantothenic acid, but isn't that simply because one cannot prescribe things like vitamins/mineral/herbal supplements? A deficiency in Vitamin C, for example, can produce scurvy, however doctors wouldn't be able to prescribe you Vitamin C. They would, most likely, recommend it.
Also, perhaps someone could add that while studies are scarce, a large amount anecdotal evidence seems to support pantothenic acid's positive effects on acne? —The preceding unsigned comment was added by 74.132.210.179 ( talk) 03:37, 25 April 2007 (UTC).
Yes, doctors do prescribe vitamins. My doctor prescribed me vitamin C tablets for my knee ligaments, even though he said "The use of this is controversial". He meant I was wasting my time and his. 78.151.26.19 ( talk) 03:00, 28 October 2015 (UTC)
Ben. Ben-Natan ( talk) 04:21, 18 November 2014 (UTC)
The article says this stuff doesn't do anything for hair. This is just wrong. If I take pantothenic acid for two days my hair is thicker. My nails also grow noticeably faster, almost to the point where it's a nuisance. 78.151.26.19 ( talk) 02:55, 28 October 2015 (UTC)
Hello fellow Wikipedians,
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Cheers.— cyberbot II Talk to my owner:Online 08:41, 6 February 2016 (UTC)
I am creating the same format for DRIs for all B vitamins. That is a U.S.- based system that identifies Estimated Average Requirements (EARs), Recommended Dietary Allowances (RDAs), Adequate Intakes (AIs) if there is not enough information to establish EARs and RDAs, and Tolerable Upper Intake Levels (ULs). Another major regulatory agency that has established ULs is the European Food Safety Authority (EFSA). ULs for both are provided, as they often differ. If there is a UL (for some vitamins none has been determined) then rationale is covered in a Toxicity section. In addition to DRIs, the U.S. also established Daily Value, using it on food and dietary supplement labels as % DV. DVs were based on older RDAs and as of 2016 have never been updated to reflect the newer DRIs. Thus, often a product that has 100% DV and greater than 100% RDA. Examples given for each vitamin. What I have written can be improved. It lacks EFSA or other major country RDAs. It lacks an estimate of what percentages of people are deficient - although that is often covered in a separate section on deficiency and consequences of deficiency. I am creating this Subject in all of the Talk pages of the vitamin entries I have edited. Comments and improvements are welcome. David notMD ( talk) 12:16, 3 March 2016 (UTC)
I glanced at Wikipedia:WikiProject_Chemicals/Chembox_validation, but I don't understand why many of those IDs are reported "changed", when they match the linked sites. -- Diblidabliduu ( talk) 20:53, 3 February 2018 (UTC)
Working to bring article to be closer to state of completeness seen in B-class and GA vitamin articles. David notMD ( talk) 11:39, 1 June 2020 (UTC)
GA toolbox |
---|
Reviewing |
Reviewer: HaEr48 ( talk · contribs) 02:31, 20 June 2020 (UTC)
Reviewing. HaEr48 ( talk) 02:31, 20 June 2020 (UTC)
Thank you for writing this interesting article. Re my GA nominations, lol I have been waiting for them sitting idle, and now suddenly I have three in review :) I'll manage somehow. As for this article, in general it is in good shape, but I have some feedback especially for clarity and completeness. My feedback is below:
--Thank you. HaEr48 ( talk) 23:06, 20 June 2020 (UTC)
HaEr48I believe I have addressed all of this set of requests/queries. David notMD ( talk) 20:25, 26 June 2020 (UTC)
Pantothenic acid has been listed as one of the
Natural sciences good articles under the
good article criteria. If you can improve it further,
please do so. If it no longer meets these criteria, you can
reassess it. Review: July 3, 2020. ( Reviewed version). |
This
level-5 vital article is rated GA-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||||||||||||||||
|
There is a substantial body of literature that argues for Vitamin A reduction of acne, and there are also documented cases of high-dose B vitamins /causing/ acne: PMID 1834437 -- crl620 04:49, 5 May 2006 (UTC)
This article needs a complete rewrite. There is little information actually pertaining to Pantothenic acid, and lots of random junk about Dr. Lit-Hung Leung's research.
The 'study' performed by Dr. Lit-Hung Leung is extremely vague, published in a rediculous journal, and used commonly to sell B5 pills. The wiki page reads like an infomercial:
"Though this study was done in 1997, news did not spread...however, by word of mouth and eventually the internet, success stories have came in by the thousands..."
Here's the Leung article: PMID 7476595
It was published in the journal "Medical Hypotheses," which is described on their site as:
"Medical Hypotheses takes a deliberately different approach to peer review. Most contemporary practice tends to discriminate against radical ideas that conflict with current theory and practice. Medical Hypotheses will publish radical ideas, so long as they are coherent and clearly expressed. Furthermore, traditional peer review can oblige authors to distort their true views to satisfy referees, and so diminish authorial responsibility and accountability. In Medical Hypotheses, the authors' responsibility for the integrity, precision and accuracy of their work is paramount. The editor sees his role as a 'chooser', not a 'changer': choosing to publish what are judged to be the best papers from those submitted."
It looks like it's a journal without any review system.
Overall the data on the wiki are poorly cited and shallow.
The wiki lacks clear scientific evidence and has no sources (minus the link to "Coenzyme-A Technologies", a company selling skin products).
Legitimate and well regarded sources tend to disagree with some of the suggestions on the wiki page. The Pauling Institute describes pantothenic acid as helping to heal skin wounds, whereas the wiki article says that "Some users report that cuts heal very slowly."
Some key facts about pantothenic acid are missing, such as recent research, absorption as d-Calcium pantothenate, chemical structure, and metabolism. As Dan| says below, the information about metabolism and "part of Coenzyme-A" makes no sense. To answer Dan's question, the pantothenate is a CoA precursor: KEGG CoA Pathway
This article needs to be substantially rewritten.
Could someone please edit the painfully anthropomorphic "Insulin receptors are acylated with palmitic acid when they do not want to bind with insulin.[22] " Joel1947 ( talk) 18:25, 17 November 2015 (UTC)
Yes about the want to part, change it to acylation decreases binding of insulin to its receptors. FeritTuzer ( talk) 08:12, 26 January 2020 (UTC)
Regarding "It is also needed for proper and healthy growth of hair," is this here because certain shampoo companies say it's true or because it's actually the case? All I can find are suggestions that the use of this chemical in shampoos has no effect, eg [1] - 203.132.90.8 03:39, 4 Jun 2005 (UTC)
From personal experience: it is actually the case. 78.151.26.19 ( talk) 03:02, 28 October 2015 (UTC)
"Specifically, it is part of coenzyme-A (CoASH) in the metabolism and transfer of carbon chains."
Using B5 as a treatment to acne really does work. I myself have had amazing results from it, and I am also aware of several other successful cases. I can't agree or disagree with the reasoning behind it, but there is little point arguing its effectiveness having seen the dramatic changes it has had.
Journal of Cosmetics, Dermatological Sciences and Applications, 2012, 2, 132-135 doi:10.4236/jcdsa.2012.23026
www.scirp.org/fileOperation/downLoad.aspx?path=JCDSA20120300001_63880780.pdf predatory publisher&type=journal
"Conclusions: The results from this study indicated that the administration of a pantothenic based dietary supplement in healthy human adults with mild to moderate acne vulgaris is feasible, safe and well tolerated. Secondary analysis shows that administration of the study agent significantly reduced global facial blemishes. Further randomized, placebo-controlled trials are warranted."
thiamine—1.5 mg, riboflavin—1.7 mg, niacin—20 mg, pyridoxine—2 mg, folic acid—400 mgc, cyanoco-balamin—6 mcg, biotin—300 mcg, pantothenic acid— 2.2 g and L-carnitine—733.3 mg. : half of these a day
slightly relevant to the article
From the article, under disputed uses -> acne
"few if any dermatologists prescribe high-dose pantothenic acid."
Admittedly, few dermatologists (or any doctors, for that matter) prescribe pantothenic acid, but isn't that simply because one cannot prescribe things like vitamins/mineral/herbal supplements? A deficiency in Vitamin C, for example, can produce scurvy, however doctors wouldn't be able to prescribe you Vitamin C. They would, most likely, recommend it.
Also, perhaps someone could add that while studies are scarce, a large amount anecdotal evidence seems to support pantothenic acid's positive effects on acne? —The preceding unsigned comment was added by 74.132.210.179 ( talk) 03:37, 25 April 2007 (UTC).
Yes, doctors do prescribe vitamins. My doctor prescribed me vitamin C tablets for my knee ligaments, even though he said "The use of this is controversial". He meant I was wasting my time and his. 78.151.26.19 ( talk) 03:00, 28 October 2015 (UTC)
Ben. Ben-Natan ( talk) 04:21, 18 November 2014 (UTC)
The article says this stuff doesn't do anything for hair. This is just wrong. If I take pantothenic acid for two days my hair is thicker. My nails also grow noticeably faster, almost to the point where it's a nuisance. 78.151.26.19 ( talk) 02:55, 28 October 2015 (UTC)
Hello fellow Wikipedians,
I have just added archive links to one external link on
Pantothenic acid. Please take a moment to review
my edit. If necessary, add {{
cbignore}}
after the link to keep me from modifying it. Alternatively, you can add {{
nobots|deny=InternetArchiveBot}}
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When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
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source check}}
(last update: 5 June 2024).
Cheers.— cyberbot II Talk to my owner:Online 08:41, 6 February 2016 (UTC)
I am creating the same format for DRIs for all B vitamins. That is a U.S.- based system that identifies Estimated Average Requirements (EARs), Recommended Dietary Allowances (RDAs), Adequate Intakes (AIs) if there is not enough information to establish EARs and RDAs, and Tolerable Upper Intake Levels (ULs). Another major regulatory agency that has established ULs is the European Food Safety Authority (EFSA). ULs for both are provided, as they often differ. If there is a UL (for some vitamins none has been determined) then rationale is covered in a Toxicity section. In addition to DRIs, the U.S. also established Daily Value, using it on food and dietary supplement labels as % DV. DVs were based on older RDAs and as of 2016 have never been updated to reflect the newer DRIs. Thus, often a product that has 100% DV and greater than 100% RDA. Examples given for each vitamin. What I have written can be improved. It lacks EFSA or other major country RDAs. It lacks an estimate of what percentages of people are deficient - although that is often covered in a separate section on deficiency and consequences of deficiency. I am creating this Subject in all of the Talk pages of the vitamin entries I have edited. Comments and improvements are welcome. David notMD ( talk) 12:16, 3 March 2016 (UTC)
I glanced at Wikipedia:WikiProject_Chemicals/Chembox_validation, but I don't understand why many of those IDs are reported "changed", when they match the linked sites. -- Diblidabliduu ( talk) 20:53, 3 February 2018 (UTC)
Working to bring article to be closer to state of completeness seen in B-class and GA vitamin articles. David notMD ( talk) 11:39, 1 June 2020 (UTC)
GA toolbox |
---|
Reviewing |
Reviewer: HaEr48 ( talk · contribs) 02:31, 20 June 2020 (UTC)
Reviewing. HaEr48 ( talk) 02:31, 20 June 2020 (UTC)
Thank you for writing this interesting article. Re my GA nominations, lol I have been waiting for them sitting idle, and now suddenly I have three in review :) I'll manage somehow. As for this article, in general it is in good shape, but I have some feedback especially for clarity and completeness. My feedback is below:
--Thank you. HaEr48 ( talk) 23:06, 20 June 2020 (UTC)
HaEr48I believe I have addressed all of this set of requests/queries. David notMD ( talk) 20:25, 26 June 2020 (UTC)