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I think I read about xanthinol nicotinate which is kind of like caffeine attached to niacin as a lipid reducing drug Are there others Things like Niacin dimers (two niacins connected) as well as halogenated niacins like fluoroniacin or chloroniacin could have much stronger lipid changing effects with the stronger receptor affinity; perhaps even absent the niacin feeling (splenda is chlorosucrose 300 times more active at sweetness receptors)
also its possible that a phosphophenyl version of niacin (thats a phosphorus where the nitrogen is) may have novel drug effects
It would be beneficial to list the various niacin drugs here
picamilon niacin linked to GABA—Preceding unsigned comment added by 140.211.132.187 ( talk) 16:16, 2 June 2010 (UTC)
[quote]It has historically been referred to as "vitamin PP" or "vitamin P-P".[/quote]
I'm assuming this is a comical reference to the side effect by which vitamins yellow the urine, but I don't know enough about Niacin to be sure. Anybody clarify this?
96.235.5.224 ( talk) 12:02, 5 January 2010 (UTC)
The suffix "carboxylate" indicates an ester or a salt of a carboxylic acid. Nicotinic acid is neither.
71.241.104.251 02:34, 12 August 2007 (UTC)
The -ate suffix for acids is nowadays often used (e.g. lactate, acetate, instead of lactic or acetic acid) in biochemical writing to refer to acids that under physiologic pH conditions are largely ionized. CharlesHBennett ( talk) 05:44, 15 May 2015 (UTC)
C6H4NO2- or C6H5NO2 (neutral). The SMILES should match one or the other.
REferance: MedlinePlus Herbs and Supplements: Niacin http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-niacin.html
Where it says "inadequate dietary intake of vitamin B3 may also therefore lead to depression", is that "may" as in "sometimes causes depression" or "may" as in "some people think it causes depression (but there's no hard evidence either way)"?
Also, what's this "Vitamin P" business?
-- 221.249.13.34 05:16, 4 Nov 2004 (UTC)
I believe Vitamin P is an older name for niacin derived either from "paprika", a rich source of niacin, or from "pellagra" (or "pellagra-preventive"), referring to the deficiency disease. D021317c 21:21, 13 December 2006 (UTC)
It would be nice to have a list of a few foods or plants that are rich in niacin on this page. The
Hominy page mentions that "The process also converts some of the niacin in the maize into a form more absorbable by the body"...
(I didn't write that last, unsigned paragraph.) Lye destroys a chemical (I'm drawing a blank at the moment) which blocks the absorption of niacin. According to _Understanding Nutrition_ (8th edition: instructor's edition)
ISBN
0-534-54612-9, page 301, "At least 70 percent of the niacin in corn is bound to complex carbohydrates and small peptides, making it unavailable for absorption. Furthermore, corn is high in the amino acid leucine, which interferes with the tryptophan-to-niacin conversion, thus further contributing to the development of pellagra." I'm pretty sure I once knew the name of the chemical I'm thinking of. Oh, well.
D021317c
21:21, 13 December 2006 (UTC)
This page links to the disambiguation page corn, but I'm not sure which sense is intended. Can you help? Thanks. — Pekinensis 23:34, 27 May 2005 (UTC)
I realized that the reference was redundant in the first place and removed it. — Pekinensis 03:56, 15 Jun 2005 (UTC)
Just a quick note, whoever added the information about tryptophan bioavailability in corn did an excellent job, wiki needs more of this level of relevant public health information. It should be cited though - did this come from any peer-refereed journal? Added a "citation needed" note. 72.186.157.71 ( talk) 17:54, 1 September 2008 (UTC) Never mind, there is a citation but the text was copied directly out of a medical information page. I put the text in quotes, but it looks choppy - can someone clean it up? 72.186.157.71 ( talk) 17:57, 1 September 2008 (UTC)
If this is true won't other drugs also be eliminated by the higher rate of metabolism? Why simply specify THC, why not DMT or DET? Or any other drug for that matter (that is metabolised by the liver)?
No scientific evidence indicates that taking niacin can alter a urine drug test result. However, readily accessible information on the Internet lists ingestion of niacin as a way to prevent detection of tetrahydracannabinol (THC), the main psychoactive ingredient of marijuana.
{{
cite journal}}
: Unknown parameter |MMWR_Type=
ignored (
help); Unknown parameter |issue_Num=
ignored (
help) (emphasis mine, for the anon below who thinks we don't read actual encyclopedias) --
Bazzargh (
talk)
10:43, 4 March 2008 (UTC)
Since Niacin speeds up metabolism, is it now the chic replacement for ephedrine for weight loss
- In response to the above question, it probably helps with those too. THC was probably mentioned for two reasons.
No, because THC is the only one that clings to fat cells.
This whole wikiepedia thing is dumb. I know for a fact than 500-1000 mg of niacin (taken right) flushes THC out out of your system in less than 6 hours. Maybe you should all start reading the actual encyclopedia and not the one where a bunch of know it all wannabe dawkins are spewing their beliefs. (Or you all could just start smoking pot, it's good man I tell ya.) P.S. Whoever posted that last comment about the fat cells, thank you for not being so dumb. — Preceding
unsigned comment added by
68.10.1.118 (
talk)
haha I agree, i was shocked to see wikipedia saying that 'scientific studies' show that niacin doesn't work, when me, my ex-gf, and even 2 of my friends have tried niacin and it worked for urine drug screens.. lol this type of shit makes me question wikipedia now.. seriously though, i'm not writing this to bullshit, which is why i came to wiki in the first place... pfft.
good luck trying to get a source for it though, just try to consider how that would even be possible... -signed, truthful herb user (98.227.47.177)
Shouldn't the citation for niacin not working to flush out pot be put after it says that instead of after it says that people try to use it for that? It makes it sound like it's an unsupported claim. On a personal note I love that a guy that can't spell wikipedia and makes unreferenced claims accuses writers on this site of spewing their beliefs! 70.94.34.208 ( talk) 04:38, 4 March 2008 (UTC)
Adding in my claim that this section needs to be adjusted. I've passed tests within 24 hours of smoking and then super-loading niacin and I know it works. All but two people I have suggested the method to have failed (and they failed because they didn't trust the method and went and bought the stuff you drink... which got detected). Scientific study my ass. One bogus source proves nothing. Damn Wiki. -Almega
Tell me if this does not solve the question, because it seems that this is exactly what niacin does and if it does it would take out thc no problem.
Niacin has the property of causing the small blood vessels to increase in size. These are the capillaries. Now, capillaries are often so small that the blood cells pass through them in single file. It is the capillaries that take care of the vast majority of all the cells in the body. You have large arteries near the heart, and they get smaller and smaller as they extend from the heart. But, at the end of every well-sized artery is a very large network of capillaries. They all start from the heart -- but at the end of the line they are tiny, tiny capillaries.
In fact, niacin does this -- it causes these miles of tiny capillaries to increase in size. It is the INCREASE in size, partly, which causes your skin to get red.
But, there is something else going on. I don't know of very many researchers who have told this story in terms that the average person can understand. There is another substance to learn a bit about -- it is a hormone called "histamine." You know of this substance when you buy "anti-histamine" medicines. Without getting into a long story on that, the "anti-histamine" substances are meant to reduce the action of histamine -- this is usually not good!( http://www.shanti.com.au/cleanses/niacin_flush.htm)karl Loren Website: http://www.oralchelation.com
Marijuana screening has a 66 % chance for a false positive ---(Center for Disease Control, The Results of Unregulated Testing, Journal of the American Medical Association (April 26, 1985).
In Abbie Hoffman and Jonathan Silvermans book 'Steal This Urine Test', they comment on how companies vary on policy as to what 'grey area' THC levels are considered 'beyond false' , as well as documenting recognized OTC and other chems that would create an inconclusive test. So with a 33 percent accuracy rate on THC screening, there are alot of unlucky (and lucky ) people out there as far as Pre and Random testing is concerned.---perceive with reason —Preceding
unsigned comment added by
Perceive with reason (
talk •
contribs)
01:52, 23 January 2009 (UTC)
/ —Preceding unsigned comment added by 216.125.168.2 ( talk) 21:28, 3 November 2009 (UTC)
Don't count on the false positives of screening tests for a defense. They are notoriously inaccurate, however the positives are generally sent for confirmatory testing (e.g. chromatography , spectroscopy, antibody etc.). From what I read above, maybe the niacin interferes with the screening test? The niacin molecule is an aromatic dynamo. It is excreted in the urine in high concentrations. So...? However... It does effect "THC" receptors (Plant extract may block cannabis addiction" http://www.newscientist.com/article/dn11904-plant-extract-may-block-cannabis-addiction-.html
It might be mentioned that Niacin is one of the 3 primary ingredients used in the enrichment process of flour.
http://www.wholefoods.com/healthinfo/enriched.html
Since this is misc, I might as well ask here, would it be good or bad for you for Niacin to be one of the ingredients of a sports drink?
There's also a band called Niacin.
Second paragraph, someone altered the sentence, "Nicotinic acid was first discovered from the oxidation of pootie tang" Someone playing a joke, but I have no idea what it should really say...
(I didn't contribute the paragraph above.) According to Merck Index 13 ISBN 0911910-13-1, section 6552 Nicotinic acid, "Prepn by oxidation of alkyl beta-substituted pyridines: A. Ladenburg, _Ann._ *301*, 152 (1898)." According to its list of abbreviations, _Ann._ means _Justus Liebig's Annalen der Chemie_. No information yet on discovery. D021317c 21:34, 13 December 2006 (UTC)
Something is missing at the second line of the main niacin article, probably an eduting error. —The preceding unsigned comment was added by 24.4.16.102 ( talk • contribs) 05:45, 24 January 2006 (UTC).
I went and googled for "Michalek effect" and came up with nothing. I find this suspicious. -- kop 06:48, 24 February 2006 (UTC)
I searched Pub Med and other medical dictionaries. I am pretty confident that the condition described by the term "Michalek effect" is not scientificly investigated nor accepted by any medical clinicians as an actual phenomenon. Niubrad 03:00, 25 August 2006 (UTC)
I have checked as many sources I could for behavioral changes and the so-called "Michalek effect". None found. Will remove from article. Ifnord 04:40, 5 September 2006 (UTC)
Someone please correct the picture of the synthensis pathway with the enyzmes, I don't have a program to draw them. This should be the pathway:
Tryptophan --(Tryptophan oxygenase)--> N-formylkynurenine --> Kynurenine --> 3-OH kynurenine --(B6, Kynureninase)--> 3-0h xyanthranilic acid --> --> -->Niacin
Source: Introduction to clincal nutrition, 2nd edition Vishwanath Sardesai 2003
141.217.221.212 22:01, 25 March 2006 (UTC)AStudent
I have high blood pressure (hypertension) and have been told that niacin is no good for a person who is hypertensive is this so? why? This is a B complex suplement from a health shop.
My doctor has PRESCRIBED niacin to address my hypertension, but there are some mild side-effects: http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-niacin.html
-K
I edited the references in this article to at least give descriptive names, and sort out the numbering. The web refs still need to be properly cited, though. I will put this page on my to-do list. Apart from the somewhat dodgy references, it would do me good to do a literature survey on this topic. -- Slashme 09:50, 2 May 2006 (UTC)
niacin is believed to be the best treatment for many types od coronary heart disease, IT SAVE MY LIFE; refer to LIFE EXTENSION MAGAZINE --MARCH 2007.
I think that the part regarding the use of niacin as vasodilator should be removed since I couldn't find any reference to this use in any book of pharmacology I looked. Plico 17:13, 12 May 2006 (UTC)
deleted text: A large amount of B3 Ingested can increase your sex drive. Plico 17:13, 12 May 2006 (UTC)
When you use systematic, naked reverts & trivially refuted, uncivil labelling to describe my edit, "08:37, 23 June 2006 Ackoz (rv no pseudoscience per WP:NPOV)" [2], I construe that as a personal attack [3](it was knowably not a legitmate comment on content for a doctor). Almost everything you deleted there [4](one exception) was sourced from Dr William Parsons' latest book (and in conjunction with other conventional references). Parsons *is* the longest recognized, and best documented, US conventional medical authority on niacin for dyslipidemias [5], where you also deleted the reference to his book (best accessible reference for the public). And although you may deny this is WP:NPA, I commend review of the words "broaching", "breeching" as well as " wikilawyering"
If you want to be constructive, addressing European sources and extended, rigorous evidence on inositol hexanicotinate (IHN), would be nice. Here in North America, there seem to be a lot of IHN failures with some niacin/nicotinate interested parties, from reports of hit or miss results to outright allegations of medical/scientific fraud(!) and hydrolysis issues. Whether this is a source problem or what is going on, I don't know, but I am sure there is a problem here (# of strong medical sources) and no one publicly seems to be talking or working the problem. Reports on inositol hexanicotinate do vary.-- 69.178.41.55 07:01, 24 June 2006 (UTC)
For all the claims on how much better the hexanicotinate IHN is than plain niacin for dyslipidemias, there really ought to be better evidence than two VERY small human trials from 1961 (neither of which was big enough to measure any clinical endpoints). Did I miss something? Because this question surely isn't something that yields well to a standard 1965+ medline search (as I find to my frustration), which possibly is why the "pro" references all seem to be indirect: which is to say, to popular books which refer in turn to very old studies in rather obscure journals.
So, how about putting in some updated material on this compound, OR else noting that recent class A info just doesn't exist? Both are fair ways of dealing with lack of information. Breathless endorsements based on tiny 45 year-old short-term trials, are not how standard science-based, evidence-based medicine is supposed to work. Steve 16:03, 24 June 2006 (UTC)
There isn't any. Or let's put it this way: The Inositol Hexaniacinate Monograph in Alt Med Review 1998;3(3):222-223 compounds the error by citing only the Dorner and Welsh clinical trials from 1961 (and neglects to mention that El-Enein 1983 was with rabbits). A case study (no benefit at up to 2000 mg/day) by RB Morris [Preventive Cardiol 2006;9(1):64-65] cites Ziliotti 1977, Agusti 1978 and Kruse 1979. Z & K reported no benefit. A reported 8.2% decrease, but it was an uncontrolled trial. Z used 1326 mg/day in 59 subjects and reported no significant improvement in total chol and a trend for DECREASED HDL-C. Finally, AM Benjo [Atherosclerosis 2006;187:116-122] reported no lipid improvements after 3 mo at 1500 mg/day. So like many other dietary supplements, a mountain of marketing balanced upside down on a weak peak of conflicting evidence. David notMD ( talk) 16:50, 19 May 2009 (UTC)
Harris - I added content to the text. Apologies that I have been too lazy to learn how to properly cite references rather than just embed them in the text. David notMD ( talk) 15:36, 1 June 2009 (UTC)
This article needs additional citations for
verification. (July 2007) |
Nicotinic acid is one of the oldest drug used to treat dyslipidemia being able to affects all lipid parameters [Knopp et al. Metabolism, 1985, 34:642-650] It has been reported to lower triglycerides by 35% to 45% and LDL-c by 20% to 30% [Knopp 1985].
Niacin in large quantities is a vasodilator. Large amounts of niacin (either from vitamin B3 tablets or from treated meats) may cause dose related, harmless and short-lived sensations ranging from a mildly pleasant warm flush to tingling to extreme skin flushing resembling a sunburn, itching, gastric disturbances, and lowering of blood pressure. The amide form (strictly speaking a provitamin) does not cause these side effects, but is also not as easily assimilated by the body.
This niacin flush occurs as a result of releasing histamine about 10 minutes to 2 hours after ingesting the niacin supplement(s), typically 5-30 minutes, depending on the supplement's disintegration, dissolution and absorption. Thus, even with "pure", "immediate release" niacin supplements, absorption, and any flush, will vary greatly with nature of the supplement (capsule, tablet, excipients, press, size) and the proximal meal's timing before, during, or after, size and menu. The flushing usually recedes during the first week(s) if gram amounts are consumed in divided doses as recommended for high cholesterol treatment, starting low and increasing stepwise every several days. Sometimes aspirin and vitamin C are used to ameliorate the flush. "Slow release", "extended release" and "no-flush" formulas are available to minimize or avoid a flush, but have other practical differences that need to be carefully considered. Some persons with an unusual metabolism have an unusually large native tolerance to "immediate release" niacin without flushing, often a nutritionally or even medically significant circumstance.
Large doses of niacin (as nicotinic acid, but not the niacinamide form) are prescribed to combat
high blood pressure and to broadly improve blood
cholesterol levels. Niacin is used to treat dyslipidemas because of its low cost and its unique ability to improve lipid profiles for ApoB, LDL, small dense LDL, HDL, HDL2b - an extremely good cholesterol, Lp(a), fibrinogen and triglycerides
[1]
[2]. Pharmacologic doses of niacin (1.5 to 6 grams/day in divided doses) typically reduce
LDL cholesterol levels by 10 to 25 percent and
triglyceride levels by 20 to 50 percent.
HDL cholesterol levels are also typically increased by 15 to 35 percent.
[3]
Brand-name medications include Niaspan®, Niacor® and Nicolar®. Most slow-release pharmaceutical preparations are more stressful to the liver, repeated overdosage can be dangerous. There is disagreement as to if pure, immediate release nicotinic acid is harmful to the liver, possibly due to the confusion with the more dangerous pharmaceutical preparations.
The niacin treatment discoverer, Abram Hoffer, and other orthomolecular proponents generally add a full spectrum vitamin B formulation, such as B-50, and 1 to 4 times as much vitamin C as niacin to reduce liver stress. Liver cell activation and stress is easily monitored in the liver enzyme panel along with blood cholesterol measurements. Because of the liver stress associated with heavy alcohol consumption, regular drinkers and alcoholics may experience antabuse-like reactions with pharmacologic levels of niacin.
An esterified, no-flush derivative of niacin called Inositol hexanicotinate (IHN), also known as inositol hexaniacinate, is slowly hydrolyzed and has no reported side effects using 4 grams daily. [4] Peak blood concentrations have been reported to be at 10 hours, but suggested dosing is at least 4 times a day. It is used extensively in Europe for Raynaud's disease. There is no known monotherapeutic treatment for cholesterol dyslipidemas that is more broadly effective and as gentle [5].
Another form of vitamin B3, niacinamide, has been used since the 1940's for osteoarthritis and rheumatoid arthritis with tremendous success [6] [7] [8] reported by William Kaufman, MD, PhD [9] (1910-2000). Kaufman's recommended usage is about 4 grams a day in divided doses, more frequently being better. Dr. Kaufman advocated 500mg, and even 250mg doses, many times a day as being better than 1,000 mg 4 times a day. Nicotinic acid at least partially breaks down to niacinamide, so less niacinamide is needed if niacin treament for cholesterol is being used. Niacinamide may be safer for the liver than nicotinic acid, but nutritional supplement proponent and expert Michael Murray recommends testing liver function every 3 months when taking any high-dose form of niacin. Dr. Hoffer reports he has never seen liver problems result from taking any natural form of niacin with at least equal amounts of vitamin C [10].
Vitamin B3 has also been used in nutritional treatments of alcoholism, cancer, Bell's Palsy, schizophrenia, senility and other mental illnesses by orthomolecular practitioners [11]. These treatments are largely based on improved circulation, NAD related energetics and cellular repairs, and the correction of abnormal indole metabolites. Often the nicotinamide form is used, as its lack of a flush is easier to self administer with new patients. Unfortunately orthomolecular psychiatric treatments remain adversarially disputed over disagreements about measurement, diagnosis, efficacy, protocols and specific populations. Recently interest in niacin as a phosphate reducing agent was generated by a clinical study from India where it was found to dramatically reduce high serum phosphate levels in chronic renal failure patients on hemodialysis.( K.Sampathkumar et al in International urology and nephrology,2006;38(1):171-4)
I chopped that out because it mingles confusion, repetition, poor phrasing (arrived at by serial edits I expect) misinformation, and linkspam.
Nicotinic acid but not Niacin has been used to reduce Cholesterol. It isn't very good at it. I'd want to see a reference to why a vasodilator would need to release histamine to cause flushing, and why it would be a good idea to take repeated doses of something that did that.
I do have one patient who for several reasons is treated with it. It doesn't work very well. Midgley 13:35, 25 June 2006 (UTC)
Midgley -- could you produce your science? Also, are you sure nicotinic acid and not niacin is used to treat cholesterol? This doctor disagrees with you. ImpIn | { talk - contribs} 18:49, 23 May 2008 (UTC)
I'm going to clean up the medical use part a bit, right now it has a long and pointless abstract sounding paragraph in it.
Fuzbaby (
talk)
21:02, 9 June 2009 (UTC)
Hey folks, I changed link 48 in the therapeutics section as it wasn't right for the context. It now has a reference that is directly related to the context.. ie. that niacin doesn't work particularly well when added alongside statins. The old reference did not deal with this matter at all, rather it was very poor quality journalism that dealt with the drug combo of laropiprant and niacin (not statin and niacin!). I say poor quality without hesitation because not once did the article mention that the study in question was about a drug combination therapy. The whole article pretended the research was for a single drug therapy, and this is simply false (see here for the study: http://www.nejm.org/doi/full/10.1056/NEJMoa1300955 ). In any case, false or not, the article was not right for the text in question, and this is why it needed to be changed. Zarkme ( talk) 01:56, 21 July 2014 (UTC)
There have been enough studies of various lipid treatments that meta analysis is appropriate. Basically, we don't care about lowering cholesterol with drugs or nutrients that don't change your cardiac event rate or your mortality risk. What good does it do you to die with good numbers? That's not the point. I'm even suspicious of treatments that lower cardiac event rate, if they don't at least show a trend toward lowering mortality risk. That may be a power problem, but if you don't at least see a trend toward lower mortality, it makes you wonder a lot about some compensitory bad effect. And at the very least, it means you need to treat a BOATLOAD of people to save even one life, like tens of thousands of patients for many years. At that point, it starts to look better to spend your money and time workin on people's blood pressure and the kind of car they drive, than working ot make sure they're swallowing multiple niacin pills.
In any case, the meta anaysis shows that statins, cholesterol binding resins, and fishoil have saved lives in proper studies. There's no evidence that fibrates or niacin do, yet there have been plenty of studies: PMID 15824290. In fact, niacin, fibrate and diet therapy all flunk badly, not even showing a trend.
When it comes to lowering cholesterol or triglycerides, all these treatments of course work, though they vary a great deal in what lipids they treat (fish oil and fibrates working better on triglycerides, statins on LDL, and so on). But again, who cares about fixing numbers? The cardiac event rate is way down for statins, in keeping with lower motality, as also of course for fish oil and resins. However, it's down only about 25% for fibrates and about that much also for niacin (too few studies to give confidence limits on niacin). That's why these treatments fail to show mortality drops. In fact, there's some evidence that some older fibrates (paticularly clofibrate with 25% excess mortality in a 150,000 man-years trial, see PMID 6105515) actually increase mortality. And the most commonly used fibrate (fenofibrate) used because still on-patent, has almost no long term data at all. The old gemfibrozil from VA-HIT showed a decrease in event rate but still no mortality drop, and it had equal power to most of the statin trials which did at least show mortality decrease trends. In any case, 30 trials with 4700 subjects failed to show any mortality drop in treating coronary disease with niacin: PMID 15653014. Basically niacin, and the fibrates as a class, treat lab tests. But are a bust at saving lives. I would suggest for both of them that you're treating yourself rather than your patient. But enjoy. Steve 22:59, 25 June 2006 (UTC)
Someone said that the amide form does not cause flushing... does anyone know of a reputable company that sells it that way? I have GNC multivitamins for pregnant/breastfeeding persons and it contains niacin in the amide form but finding a niacin supplement that way seems much more difficult and GNC doesn't carry it. There are several forms that niacin is sold in : nicotinic acid, nicotinamide, and Inositol Nicotinate. Which form is the most easily digestable? I'm also frustrated by labels that just say niacin! I guess they're refering to nicotinic acid. What other differences are there between those three different forms of niacin? Also, I know that it's best to drink a glass of orange juice with iron supplements... what's best to take with niacin supplements?
Can Someone add the different niacin products available: Extended release only available by Rx-as Niaspan. Others are dietary supplements offered over the counter products-Immediate release and Sustained Release. Sustained Release Niacin is associated with a higher risk of hepatotoxicity. (Can someone add this and reference it please-thanks)
Prescription is immediate or sustained. Dietary supplements claim to be either immediate or sustained, plus the weak-evidence supported "flush free" inositol hexaniacinate, which does not have a prescription match. The most often cited ref for sustained relief being higher risk of hepatotoxic is McKenney JM, et al. JAMA 1994;271(9):672-677. David notMD ( talk) 15:41, 1 June 2009 (UTC)
Good old L. Ron makes a pretty healthy mention of Niacin (The "Educated" Vitamin) in his book Clear Body, Clear Mind. It apparently sunburns people in the shape of a bathing suit. Also, it has something to do with the toxins! — Preceding unsigned comment added by 131.230.52.162 ( talk) 19:40, 21 September 2006
→ It seems to be working ok for the 9/11 rescue workers - [7] Johnalexwood 11:52, 9 October 2007 (UTC)
Someone should add something about the difference between OTC Immediate release versus OTC Extended release--thanks — Preceding unsigned comment added by 70.113.207.158 ( talk) 00:56, 29 November 2006
The words "a synthetic indole" seem out of place. D021317c 21:05, 13 December 2006 (UTC)
Note: some of these sites sell products that I can't recommend!
[8]The niacin page at Doctor Yourself.
[9]The Life Extension Foundation -- search it for niacin, Abram Hoffer, nicotinic, etc.
[10]Duane Graveline's website. See also [11]his Wikipedia page.
Search for "Hoffer" in conjunction with "niacin" for plenty of references to psychiatric and circulatory connections. As for niacin's action as a vasodilator, that's beyond controversy (and so is the role of histamine in the process). Apparently there still remains some controversy over whether it's better when trying to manage blood lipids to take a form of niacin which avoids the "niacin flush" (such as time-release forms, niacinamide, inositol hexanicotinate, etc.) or one which causes "niacin saturation" and (usually) a concomitant flush. Abram Hoffer, whose experience with niacin in large doses is utterly unparalleled, seems (to me) to be saying that only pure niacin (nicotinic acid) is effective, and if I read him correctly, the flush is unavoidable. Don't confuse the lipid-altering with the psychiatric therapies. Though schizophrenia has been treated with niacinamide (avoiding the flush), it has also been suspected of increasing the incidence of depression. D021317c 22:35, 13 December 2006 (UTC)
If I take Naicin/ vitamin B am I taking nicotinamide? Should I avoid Niacin to live longer? The following article indicates that nicotinamide binds the sirtuin molecule to inhibit its activity.
In recent years, scientists have discovered that a family of enzymes called sirtuins can dramatically extend life in organisms as diverse as yeast, worms, and flies. They may also be able to control age-associated metabolic disorders, including obesity and type II diabetes. ( http://www.wistar.org) Using the techniques of structural biology, the Wistar team demonstrated that a component(nicotinamide) of the common vitamin B3, also known as niacin, binds to a specific site on the sirtuin molecule to inhibit its activity. -- Oxy49 21:09, 18 February 2007 (UTC)
In the article, it mentions a person taking 36 capsules containing 500 decagram of niacin. 36x500=18000 decagram, or 180 kg. Of course this is incorrect, please rectify.
some sort of advertising thrown in^
should be changed to: most energy drinks and beer (yes beer has b vitamins)
it says the effects can be mediated by taking 0.3mg of aspirin. Shouldn't that be 300mg or 0.3g?
http://www.tylermedicalclinic.com/Baby%20Aspirin.htm Normal aspirin dosage is 300-1000mg (see aspirin dosage @ wiki) I agree this needs to be changed. LucidWay 15:03, 9 July 2007 (UTC)
I really wish that this article would cite the differences between nicotinic acid and nicotinamide. I've read some really interesting and simple articles on the internet that list the differences. Nicotinic acid helps reduce lipid levels while nicotinimide doesn't. There are several other differences... and it looks like there are some far more knowledgable people who could have written this article based on all the discussion. One more thing,what's Inositol Nicotinate? Some stores are selling this labeled as niacin. There's a difference between those 2 niacin supplements although most stores still label them both as simply niacin. What's the diffenrence with Inositol Nicotinate?
Just got back from GNC. What is niacinamide? Is it related to nicotinamide?
The first line being about Niacin being a treatment for Pelagra is inappropriate. I'm sure someone took the line right out of the television show, "House" (I just watched the episode, where they say this, near word for word). Just because someone hears this on a TV show, even if it's true, does NOT mean it should be in the first sentence of an article. I'm sure that someone watched House, and typed this in here thinking that that's all Niacin did. We don't say "Vitamin D is a treatment for ricketts" do we?
I won't change it, because I'll admit that my writing skills aren't top notch, but it should be changed and moved elsewhere, significance in an article should not be dictated by a TV show. Sirhodges ( talk) 22:28, 20 September 2008 (UTC)
"The terms niacin, nicotinamide, and vitamin B3 are often used interchangeably to refer to any one of this family of molecules, since they have a common biochemical activity." That statement, which I can't believe is correct, condones, promotes, and misstates sloppy speaking. It doesn't belong anywhere in the article, much less in the introduction. The simple facts are that "niacin" is synonymous with "nicotinic acid," "niacinamide" is synonymous with "nicotinamide," and that "vitamin B3" usually refers indiscriminately to either of them or to both. Nobody who understands those relationships would refer to nicotinic acid as "niacinamide"!
Incidentally, I disagree with Sirhodges's paragraph above. I know nothing about the television show, but that niacin administration is the ideal cure for niacin deficiency, which manifests itself as pellagra, is incontrovertible. It is the main use of niacin in medicine, and of the highest significance. Until recently, that was its only significance. Unfree ( talk) 20:24, 28 November 2008 (UTC)
The picture with the two-step oxidation of tryptophan is total BS. At least in humans, the only enzyme that handles niacin as in- or output is Nicotinate phosphoribosyltransferase (EC 2.4.2.11). Also the reference which is stated to support the claim that the body can make 1 mg niacin out of 60 mg tryptophan itself criticizes the claim and gives counterervidence.
That means niacin is totally essential. What is semi-essential, however, is the NAD biosynthesis, as there tryptophan catabolism provides chinolinic acid as precursor which is similiar enough to niacin and nicotinamide to give a second pathway to NAD in case there's no niacin nor niacinamide. But tryptophan is essential, too, so NAD-deficiency is possible. -- Ayacop ( talk) 18:01, 8 January 2009 (UTC)
I am sure I have read somewhere that, while niacin is in the B group of vitamins, it should no longer be called Vitamin B3.I do not wish to change the article though, as I am not a dietitian. ACEOREVIVED ( talk) 22:30, 17 March 2009 (UTC)
Chart suggestion for vitamins and minerals.
Having been in business with a herbal department, there appears to be a need for a standardized presentation of vitamins and minerals to provide handy information to the general public.
Suggestion the following graph, if someone with this ability can present it as so.
Recommend a stardaized chart. Top lines, recommended daily allowance.
Then prioritized items that provide the element, together with amount of item in each serving and a percentage of the recommended daily allowance.
Why?
Well say vitamin C. One glass of orange juice. 100%
Vitamin D. One egg, 20. 3%
At the bottom of the chart important co ingredients required, and or negative factors to absorption.
Percentage of daily allowance per serving of food is a necessity.
Niacin is listed as an ingredient in K-Y brand Intense arousal gel. I can only speculate that it is an active ingredient. If so, should this article include this fact and niacin's role in the gel? It is probably associated with niacin flush breifly mentioned in the article. Prometheus-X303- 01:52, 18 July 2009 (UTC)
Yes, it is used as an active. The flushing effect on ingestion is supposed to have a similar effect when applied to the clitoris - bringing blood flow to the clitoris, a warming sensation (Glycerine/Glycerol has this effect anyway) and possibly engorgment. Whether or not it does indded do this, is highly debateable. (Non-User:Rob) —Preceding unsigned comment added by 124.198.147.186 ( talk) 01:43, 27 August 2009 (UTC)
Should this section be removed? It's poorly written and not sourced. I haven't been able to find any respectable sources for substitutes for niacin in cases of allergies. —Preceding unsigned comment added by ArrogantJerk ( talk • contribs) 06:13, 25 October 2009 (UTC)
{{Multiple issues |unencyclopedic = January 2009 |POV = January 2009 |disputed=November 2008} } It would be great to cleanup the article by addressing open issues regarding the Niacin#Pharmacological uses section. As shown above, the dispute goes back to 2008 - since that time, new studies have been published. Can anyone state what the issues are (it wasn't clear, as comments on this talk page related to Pharmacological uses seem rather old). Thanks, -- 4wajzkd02 ( talk) 14:45, 20 November 2009 (UTC)
This is my first wiki entry: excuse it's illiteracy, the page is nice. in the: Biosynthesis and chemical synthesis, the first graphic titled "Biosynthesis: Tryptophan → kynurenine → niacin" the tryp. molecule is has two too many hydrogens or 1 too few double bonds : http://upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Niacin_biosynthesis.svg/400px-Niacin_biosynthesis.svg.png compare with: http://en.wikipedia.org/wiki/Tryptophan thanks for the article :)
--- This article is a mess. —Preceding unsigned comment added by 93.136.47.83 ( talk) 16:09, 1 March 2010 (UTC)
I deleted what i think was an overexplanation of the term nixtamalization. The link to the article should be used if further information regarding that term is wanted, otherwise topic would be lost among a host of lenghty intraarticle definitions.
WonderingAngel-aesc78 ( talk) 01:35, 25 May 2010 (UTC)
Deleted 3 lines explaining flushing to avoid clutter and deviation from main article. Term is already linked for its further explanation.
WonderingAngel-aesc78 ( talk) 02:36, 25 May 2010 (UTC)
I'm deleting the obvious ads for Niaspan. We'll see how long they stay off.
Echo5Joker ( talk) 11:30, 11 July 2010 (CST)
Niacin appears frequently in food ingredient lists: sometimes it is probably a vitamin supplement - but other sources say it is a "color retention agent". I am having trouble finding info about its use as a color retention agent. It would be awesome if someone knowledgeable were to add a section about this. —Preceding unsigned comment added by 99.63.211.181 ( talk) 04:15, 12 October 2010 (UTC)
I removed this image because the central chemical structure (kynurenine) is incorrect. It is missing one of the double bonds in the phenyl ring. —Preceding unsigned comment added by 96.227.89.95 ( talk) 00:15, 29 October 2010 (UTC)
here: http://www.ajcn.org/content/4/4/313.full.pdf György refered to vitamin B2 as the antipellagra factor !???? Trente7cinq ( talk) 15:16, 11 March 2011 (UTC)
This article needs additional citations for
verification. |
“ | One recommended daily allowance of niacin is 2–12 mg/day for children, 14 mg/day for women, 16 mg/day for men, and 18 mg/day for pregnant or breast-feeding women. [12] The upper limit for adult men and women is 35 mg/day, which is based on flushing as the critical adverse effect. citation needed | ” |
— Niacin, dead link |
Removed unsourced material Outelligent ( talk) 00:33, 6 August 2011 (UTC)
Maybe you can add it back, as the link #29 (Jacobson, EL (2007). "Niacin". Linus Pauling Institute. Retrieved 2008-03-31: http://lpi.oregonstate.edu/infocenter/vitamins/niacin/) has all the info (for both daily needs, as well as daily max). Here is the cit #29: [13]
I think that the first part needs revision. It says that "niacin is also known as Vitamin B3" but I have a book which says that this is no longer called Vitamin B3. It might be written on bottles and boxes that it is, but that does not make it right! Any one who knows about these things could change the opening sentence. ACEOREVIVED ( talk) 16:58, 13 March 2012 (UTC)
This link isn't a source but it references an source that seems reliable. It says 900 mg for adults. Sorry, I'm not a doctor or something. I just think the 35 mg/day is unbelievable. — Preceding unsigned comment added by 80.98.231.58 ( talk) 05:11, 17 September 2012 (UTC)
Also in developed countries mild forms of Pellagra are much common. I know this because I suffered more than 10 years from it. It took me those 10 years how to become healthy again, to find out that I need niacin! For treatment I take 2 doses with 1,5g niacin everyday, and my chronique fatigue and also my skin problems just went away. So flushing is joyful, it's like an immun reaction and makes you healthy. I would appreciate if other people who experienced mild forms of Pellagra would help to improve this article. 178.197.225.71 ( talk) 11:41, 21 August 2013 (UTC)
"Some of these symptoms are generally related to niacin's role as the rate limiting cofactor in the histidine decarboxylase enzyme which converts l-histidine into histamine." - So you know now what patients suffering from histamine intolerance need. -- 178.197.227.26 ( talk) 12:17, 21 August 2013 (UTC)
Noticed this in the Deficiency section:
Patients with alcoholism typically experience increased intestinal permeability, leading to negative health outcomes.
The reference seems to be gone, and the study that was linked previously didn't imply the conclusion made in this statement. It isn't really relevant to an article on niacin deficiency, it seems like "leaky gut syndrome" propaganda. — Preceding unsigned comment added by Tsunami3 ( talk • contribs) 23:10, 2 December 2013 (UTC)
http://www.nejm.org/doi/full/10.1056/NEJMoa1300955?query=featured_home
Wawot1 ( talk) 23:14, 17 July 2014 (UTC)
Just want to throw some cold water on the media stories re. Niacin that have appeared in the last few days. The reporting re Niacin has been erroneous in the popular press. CBC was the worst - it didn't once mention that the study in question dealt with a drug combination. Thw whole article just pretended the study only dealth with Niacin in isolation. This means that side effects of "Laropiprant" could easily be being mis-attributed to Niacin erroneously in the popular press.
So I just want to head things off and warn editors to be careful that the evidence is to date only conclusive in showing that a drug combination has adverse effects, and it cannot be so simply attributed to Niacin until more research is done.
Unfortunately I have been unable to find much info on side effects of laropiprant on its own.. it appears to be poorly studied in isolation. I get a lot of things like "Insufficient information available about LAROPIPRANT for xyz".
I want to point out:
Some quotes:
And of course, some examples of the stories / media beatups:
I'm not very good with wikipedia etiquette so sorry in advance if I am in error somehow.. Zarkme ( talk) 10:11, 18 July 2014 (UTC)
References
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![]() | This is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Archive 1 | Archive 2 |
I think I read about xanthinol nicotinate which is kind of like caffeine attached to niacin as a lipid reducing drug Are there others Things like Niacin dimers (two niacins connected) as well as halogenated niacins like fluoroniacin or chloroniacin could have much stronger lipid changing effects with the stronger receptor affinity; perhaps even absent the niacin feeling (splenda is chlorosucrose 300 times more active at sweetness receptors)
also its possible that a phosphophenyl version of niacin (thats a phosphorus where the nitrogen is) may have novel drug effects
It would be beneficial to list the various niacin drugs here
picamilon niacin linked to GABA—Preceding unsigned comment added by 140.211.132.187 ( talk) 16:16, 2 June 2010 (UTC)
[quote]It has historically been referred to as "vitamin PP" or "vitamin P-P".[/quote]
I'm assuming this is a comical reference to the side effect by which vitamins yellow the urine, but I don't know enough about Niacin to be sure. Anybody clarify this?
96.235.5.224 ( talk) 12:02, 5 January 2010 (UTC)
The suffix "carboxylate" indicates an ester or a salt of a carboxylic acid. Nicotinic acid is neither.
71.241.104.251 02:34, 12 August 2007 (UTC)
The -ate suffix for acids is nowadays often used (e.g. lactate, acetate, instead of lactic or acetic acid) in biochemical writing to refer to acids that under physiologic pH conditions are largely ionized. CharlesHBennett ( talk) 05:44, 15 May 2015 (UTC)
C6H4NO2- or C6H5NO2 (neutral). The SMILES should match one or the other.
REferance: MedlinePlus Herbs and Supplements: Niacin http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-niacin.html
Where it says "inadequate dietary intake of vitamin B3 may also therefore lead to depression", is that "may" as in "sometimes causes depression" or "may" as in "some people think it causes depression (but there's no hard evidence either way)"?
Also, what's this "Vitamin P" business?
-- 221.249.13.34 05:16, 4 Nov 2004 (UTC)
I believe Vitamin P is an older name for niacin derived either from "paprika", a rich source of niacin, or from "pellagra" (or "pellagra-preventive"), referring to the deficiency disease. D021317c 21:21, 13 December 2006 (UTC)
It would be nice to have a list of a few foods or plants that are rich in niacin on this page. The
Hominy page mentions that "The process also converts some of the niacin in the maize into a form more absorbable by the body"...
(I didn't write that last, unsigned paragraph.) Lye destroys a chemical (I'm drawing a blank at the moment) which blocks the absorption of niacin. According to _Understanding Nutrition_ (8th edition: instructor's edition)
ISBN
0-534-54612-9, page 301, "At least 70 percent of the niacin in corn is bound to complex carbohydrates and small peptides, making it unavailable for absorption. Furthermore, corn is high in the amino acid leucine, which interferes with the tryptophan-to-niacin conversion, thus further contributing to the development of pellagra." I'm pretty sure I once knew the name of the chemical I'm thinking of. Oh, well.
D021317c
21:21, 13 December 2006 (UTC)
This page links to the disambiguation page corn, but I'm not sure which sense is intended. Can you help? Thanks. — Pekinensis 23:34, 27 May 2005 (UTC)
I realized that the reference was redundant in the first place and removed it. — Pekinensis 03:56, 15 Jun 2005 (UTC)
Just a quick note, whoever added the information about tryptophan bioavailability in corn did an excellent job, wiki needs more of this level of relevant public health information. It should be cited though - did this come from any peer-refereed journal? Added a "citation needed" note. 72.186.157.71 ( talk) 17:54, 1 September 2008 (UTC) Never mind, there is a citation but the text was copied directly out of a medical information page. I put the text in quotes, but it looks choppy - can someone clean it up? 72.186.157.71 ( talk) 17:57, 1 September 2008 (UTC)
If this is true won't other drugs also be eliminated by the higher rate of metabolism? Why simply specify THC, why not DMT or DET? Or any other drug for that matter (that is metabolised by the liver)?
No scientific evidence indicates that taking niacin can alter a urine drug test result. However, readily accessible information on the Internet lists ingestion of niacin as a way to prevent detection of tetrahydracannabinol (THC), the main psychoactive ingredient of marijuana.
{{
cite journal}}
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help); Unknown parameter |issue_Num=
ignored (
help) (emphasis mine, for the anon below who thinks we don't read actual encyclopedias) --
Bazzargh (
talk)
10:43, 4 March 2008 (UTC)
Since Niacin speeds up metabolism, is it now the chic replacement for ephedrine for weight loss
- In response to the above question, it probably helps with those too. THC was probably mentioned for two reasons.
No, because THC is the only one that clings to fat cells.
This whole wikiepedia thing is dumb. I know for a fact than 500-1000 mg of niacin (taken right) flushes THC out out of your system in less than 6 hours. Maybe you should all start reading the actual encyclopedia and not the one where a bunch of know it all wannabe dawkins are spewing their beliefs. (Or you all could just start smoking pot, it's good man I tell ya.) P.S. Whoever posted that last comment about the fat cells, thank you for not being so dumb. — Preceding
unsigned comment added by
68.10.1.118 (
talk)
haha I agree, i was shocked to see wikipedia saying that 'scientific studies' show that niacin doesn't work, when me, my ex-gf, and even 2 of my friends have tried niacin and it worked for urine drug screens.. lol this type of shit makes me question wikipedia now.. seriously though, i'm not writing this to bullshit, which is why i came to wiki in the first place... pfft.
good luck trying to get a source for it though, just try to consider how that would even be possible... -signed, truthful herb user (98.227.47.177)
Shouldn't the citation for niacin not working to flush out pot be put after it says that instead of after it says that people try to use it for that? It makes it sound like it's an unsupported claim. On a personal note I love that a guy that can't spell wikipedia and makes unreferenced claims accuses writers on this site of spewing their beliefs! 70.94.34.208 ( talk) 04:38, 4 March 2008 (UTC)
Adding in my claim that this section needs to be adjusted. I've passed tests within 24 hours of smoking and then super-loading niacin and I know it works. All but two people I have suggested the method to have failed (and they failed because they didn't trust the method and went and bought the stuff you drink... which got detected). Scientific study my ass. One bogus source proves nothing. Damn Wiki. -Almega
Tell me if this does not solve the question, because it seems that this is exactly what niacin does and if it does it would take out thc no problem.
Niacin has the property of causing the small blood vessels to increase in size. These are the capillaries. Now, capillaries are often so small that the blood cells pass through them in single file. It is the capillaries that take care of the vast majority of all the cells in the body. You have large arteries near the heart, and they get smaller and smaller as they extend from the heart. But, at the end of every well-sized artery is a very large network of capillaries. They all start from the heart -- but at the end of the line they are tiny, tiny capillaries.
In fact, niacin does this -- it causes these miles of tiny capillaries to increase in size. It is the INCREASE in size, partly, which causes your skin to get red.
But, there is something else going on. I don't know of very many researchers who have told this story in terms that the average person can understand. There is another substance to learn a bit about -- it is a hormone called "histamine." You know of this substance when you buy "anti-histamine" medicines. Without getting into a long story on that, the "anti-histamine" substances are meant to reduce the action of histamine -- this is usually not good!( http://www.shanti.com.au/cleanses/niacin_flush.htm)karl Loren Website: http://www.oralchelation.com
Marijuana screening has a 66 % chance for a false positive ---(Center for Disease Control, The Results of Unregulated Testing, Journal of the American Medical Association (April 26, 1985).
In Abbie Hoffman and Jonathan Silvermans book 'Steal This Urine Test', they comment on how companies vary on policy as to what 'grey area' THC levels are considered 'beyond false' , as well as documenting recognized OTC and other chems that would create an inconclusive test. So with a 33 percent accuracy rate on THC screening, there are alot of unlucky (and lucky ) people out there as far as Pre and Random testing is concerned.---perceive with reason —Preceding
unsigned comment added by
Perceive with reason (
talk •
contribs)
01:52, 23 January 2009 (UTC)
/ —Preceding unsigned comment added by 216.125.168.2 ( talk) 21:28, 3 November 2009 (UTC)
Don't count on the false positives of screening tests for a defense. They are notoriously inaccurate, however the positives are generally sent for confirmatory testing (e.g. chromatography , spectroscopy, antibody etc.). From what I read above, maybe the niacin interferes with the screening test? The niacin molecule is an aromatic dynamo. It is excreted in the urine in high concentrations. So...? However... It does effect "THC" receptors (Plant extract may block cannabis addiction" http://www.newscientist.com/article/dn11904-plant-extract-may-block-cannabis-addiction-.html
It might be mentioned that Niacin is one of the 3 primary ingredients used in the enrichment process of flour.
http://www.wholefoods.com/healthinfo/enriched.html
Since this is misc, I might as well ask here, would it be good or bad for you for Niacin to be one of the ingredients of a sports drink?
There's also a band called Niacin.
Second paragraph, someone altered the sentence, "Nicotinic acid was first discovered from the oxidation of pootie tang" Someone playing a joke, but I have no idea what it should really say...
(I didn't contribute the paragraph above.) According to Merck Index 13 ISBN 0911910-13-1, section 6552 Nicotinic acid, "Prepn by oxidation of alkyl beta-substituted pyridines: A. Ladenburg, _Ann._ *301*, 152 (1898)." According to its list of abbreviations, _Ann._ means _Justus Liebig's Annalen der Chemie_. No information yet on discovery. D021317c 21:34, 13 December 2006 (UTC)
Something is missing at the second line of the main niacin article, probably an eduting error. —The preceding unsigned comment was added by 24.4.16.102 ( talk • contribs) 05:45, 24 January 2006 (UTC).
I went and googled for "Michalek effect" and came up with nothing. I find this suspicious. -- kop 06:48, 24 February 2006 (UTC)
I searched Pub Med and other medical dictionaries. I am pretty confident that the condition described by the term "Michalek effect" is not scientificly investigated nor accepted by any medical clinicians as an actual phenomenon. Niubrad 03:00, 25 August 2006 (UTC)
I have checked as many sources I could for behavioral changes and the so-called "Michalek effect". None found. Will remove from article. Ifnord 04:40, 5 September 2006 (UTC)
Someone please correct the picture of the synthensis pathway with the enyzmes, I don't have a program to draw them. This should be the pathway:
Tryptophan --(Tryptophan oxygenase)--> N-formylkynurenine --> Kynurenine --> 3-OH kynurenine --(B6, Kynureninase)--> 3-0h xyanthranilic acid --> --> -->Niacin
Source: Introduction to clincal nutrition, 2nd edition Vishwanath Sardesai 2003
141.217.221.212 22:01, 25 March 2006 (UTC)AStudent
I have high blood pressure (hypertension) and have been told that niacin is no good for a person who is hypertensive is this so? why? This is a B complex suplement from a health shop.
My doctor has PRESCRIBED niacin to address my hypertension, but there are some mild side-effects: http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-niacin.html
-K
I edited the references in this article to at least give descriptive names, and sort out the numbering. The web refs still need to be properly cited, though. I will put this page on my to-do list. Apart from the somewhat dodgy references, it would do me good to do a literature survey on this topic. -- Slashme 09:50, 2 May 2006 (UTC)
niacin is believed to be the best treatment for many types od coronary heart disease, IT SAVE MY LIFE; refer to LIFE EXTENSION MAGAZINE --MARCH 2007.
I think that the part regarding the use of niacin as vasodilator should be removed since I couldn't find any reference to this use in any book of pharmacology I looked. Plico 17:13, 12 May 2006 (UTC)
deleted text: A large amount of B3 Ingested can increase your sex drive. Plico 17:13, 12 May 2006 (UTC)
When you use systematic, naked reverts & trivially refuted, uncivil labelling to describe my edit, "08:37, 23 June 2006 Ackoz (rv no pseudoscience per WP:NPOV)" [2], I construe that as a personal attack [3](it was knowably not a legitmate comment on content for a doctor). Almost everything you deleted there [4](one exception) was sourced from Dr William Parsons' latest book (and in conjunction with other conventional references). Parsons *is* the longest recognized, and best documented, US conventional medical authority on niacin for dyslipidemias [5], where you also deleted the reference to his book (best accessible reference for the public). And although you may deny this is WP:NPA, I commend review of the words "broaching", "breeching" as well as " wikilawyering"
If you want to be constructive, addressing European sources and extended, rigorous evidence on inositol hexanicotinate (IHN), would be nice. Here in North America, there seem to be a lot of IHN failures with some niacin/nicotinate interested parties, from reports of hit or miss results to outright allegations of medical/scientific fraud(!) and hydrolysis issues. Whether this is a source problem or what is going on, I don't know, but I am sure there is a problem here (# of strong medical sources) and no one publicly seems to be talking or working the problem. Reports on inositol hexanicotinate do vary.-- 69.178.41.55 07:01, 24 June 2006 (UTC)
For all the claims on how much better the hexanicotinate IHN is than plain niacin for dyslipidemias, there really ought to be better evidence than two VERY small human trials from 1961 (neither of which was big enough to measure any clinical endpoints). Did I miss something? Because this question surely isn't something that yields well to a standard 1965+ medline search (as I find to my frustration), which possibly is why the "pro" references all seem to be indirect: which is to say, to popular books which refer in turn to very old studies in rather obscure journals.
So, how about putting in some updated material on this compound, OR else noting that recent class A info just doesn't exist? Both are fair ways of dealing with lack of information. Breathless endorsements based on tiny 45 year-old short-term trials, are not how standard science-based, evidence-based medicine is supposed to work. Steve 16:03, 24 June 2006 (UTC)
There isn't any. Or let's put it this way: The Inositol Hexaniacinate Monograph in Alt Med Review 1998;3(3):222-223 compounds the error by citing only the Dorner and Welsh clinical trials from 1961 (and neglects to mention that El-Enein 1983 was with rabbits). A case study (no benefit at up to 2000 mg/day) by RB Morris [Preventive Cardiol 2006;9(1):64-65] cites Ziliotti 1977, Agusti 1978 and Kruse 1979. Z & K reported no benefit. A reported 8.2% decrease, but it was an uncontrolled trial. Z used 1326 mg/day in 59 subjects and reported no significant improvement in total chol and a trend for DECREASED HDL-C. Finally, AM Benjo [Atherosclerosis 2006;187:116-122] reported no lipid improvements after 3 mo at 1500 mg/day. So like many other dietary supplements, a mountain of marketing balanced upside down on a weak peak of conflicting evidence. David notMD ( talk) 16:50, 19 May 2009 (UTC)
Harris - I added content to the text. Apologies that I have been too lazy to learn how to properly cite references rather than just embed them in the text. David notMD ( talk) 15:36, 1 June 2009 (UTC)
This article needs additional citations for
verification. (July 2007) |
Nicotinic acid is one of the oldest drug used to treat dyslipidemia being able to affects all lipid parameters [Knopp et al. Metabolism, 1985, 34:642-650] It has been reported to lower triglycerides by 35% to 45% and LDL-c by 20% to 30% [Knopp 1985].
Niacin in large quantities is a vasodilator. Large amounts of niacin (either from vitamin B3 tablets or from treated meats) may cause dose related, harmless and short-lived sensations ranging from a mildly pleasant warm flush to tingling to extreme skin flushing resembling a sunburn, itching, gastric disturbances, and lowering of blood pressure. The amide form (strictly speaking a provitamin) does not cause these side effects, but is also not as easily assimilated by the body.
This niacin flush occurs as a result of releasing histamine about 10 minutes to 2 hours after ingesting the niacin supplement(s), typically 5-30 minutes, depending on the supplement's disintegration, dissolution and absorption. Thus, even with "pure", "immediate release" niacin supplements, absorption, and any flush, will vary greatly with nature of the supplement (capsule, tablet, excipients, press, size) and the proximal meal's timing before, during, or after, size and menu. The flushing usually recedes during the first week(s) if gram amounts are consumed in divided doses as recommended for high cholesterol treatment, starting low and increasing stepwise every several days. Sometimes aspirin and vitamin C are used to ameliorate the flush. "Slow release", "extended release" and "no-flush" formulas are available to minimize or avoid a flush, but have other practical differences that need to be carefully considered. Some persons with an unusual metabolism have an unusually large native tolerance to "immediate release" niacin without flushing, often a nutritionally or even medically significant circumstance.
Large doses of niacin (as nicotinic acid, but not the niacinamide form) are prescribed to combat
high blood pressure and to broadly improve blood
cholesterol levels. Niacin is used to treat dyslipidemas because of its low cost and its unique ability to improve lipid profiles for ApoB, LDL, small dense LDL, HDL, HDL2b - an extremely good cholesterol, Lp(a), fibrinogen and triglycerides
[1]
[2]. Pharmacologic doses of niacin (1.5 to 6 grams/day in divided doses) typically reduce
LDL cholesterol levels by 10 to 25 percent and
triglyceride levels by 20 to 50 percent.
HDL cholesterol levels are also typically increased by 15 to 35 percent.
[3]
Brand-name medications include Niaspan®, Niacor® and Nicolar®. Most slow-release pharmaceutical preparations are more stressful to the liver, repeated overdosage can be dangerous. There is disagreement as to if pure, immediate release nicotinic acid is harmful to the liver, possibly due to the confusion with the more dangerous pharmaceutical preparations.
The niacin treatment discoverer, Abram Hoffer, and other orthomolecular proponents generally add a full spectrum vitamin B formulation, such as B-50, and 1 to 4 times as much vitamin C as niacin to reduce liver stress. Liver cell activation and stress is easily monitored in the liver enzyme panel along with blood cholesterol measurements. Because of the liver stress associated with heavy alcohol consumption, regular drinkers and alcoholics may experience antabuse-like reactions with pharmacologic levels of niacin.
An esterified, no-flush derivative of niacin called Inositol hexanicotinate (IHN), also known as inositol hexaniacinate, is slowly hydrolyzed and has no reported side effects using 4 grams daily. [4] Peak blood concentrations have been reported to be at 10 hours, but suggested dosing is at least 4 times a day. It is used extensively in Europe for Raynaud's disease. There is no known monotherapeutic treatment for cholesterol dyslipidemas that is more broadly effective and as gentle [5].
Another form of vitamin B3, niacinamide, has been used since the 1940's for osteoarthritis and rheumatoid arthritis with tremendous success [6] [7] [8] reported by William Kaufman, MD, PhD [9] (1910-2000). Kaufman's recommended usage is about 4 grams a day in divided doses, more frequently being better. Dr. Kaufman advocated 500mg, and even 250mg doses, many times a day as being better than 1,000 mg 4 times a day. Nicotinic acid at least partially breaks down to niacinamide, so less niacinamide is needed if niacin treament for cholesterol is being used. Niacinamide may be safer for the liver than nicotinic acid, but nutritional supplement proponent and expert Michael Murray recommends testing liver function every 3 months when taking any high-dose form of niacin. Dr. Hoffer reports he has never seen liver problems result from taking any natural form of niacin with at least equal amounts of vitamin C [10].
Vitamin B3 has also been used in nutritional treatments of alcoholism, cancer, Bell's Palsy, schizophrenia, senility and other mental illnesses by orthomolecular practitioners [11]. These treatments are largely based on improved circulation, NAD related energetics and cellular repairs, and the correction of abnormal indole metabolites. Often the nicotinamide form is used, as its lack of a flush is easier to self administer with new patients. Unfortunately orthomolecular psychiatric treatments remain adversarially disputed over disagreements about measurement, diagnosis, efficacy, protocols and specific populations. Recently interest in niacin as a phosphate reducing agent was generated by a clinical study from India where it was found to dramatically reduce high serum phosphate levels in chronic renal failure patients on hemodialysis.( K.Sampathkumar et al in International urology and nephrology,2006;38(1):171-4)
I chopped that out because it mingles confusion, repetition, poor phrasing (arrived at by serial edits I expect) misinformation, and linkspam.
Nicotinic acid but not Niacin has been used to reduce Cholesterol. It isn't very good at it. I'd want to see a reference to why a vasodilator would need to release histamine to cause flushing, and why it would be a good idea to take repeated doses of something that did that.
I do have one patient who for several reasons is treated with it. It doesn't work very well. Midgley 13:35, 25 June 2006 (UTC)
Midgley -- could you produce your science? Also, are you sure nicotinic acid and not niacin is used to treat cholesterol? This doctor disagrees with you. ImpIn | { talk - contribs} 18:49, 23 May 2008 (UTC)
I'm going to clean up the medical use part a bit, right now it has a long and pointless abstract sounding paragraph in it.
Fuzbaby (
talk)
21:02, 9 June 2009 (UTC)
Hey folks, I changed link 48 in the therapeutics section as it wasn't right for the context. It now has a reference that is directly related to the context.. ie. that niacin doesn't work particularly well when added alongside statins. The old reference did not deal with this matter at all, rather it was very poor quality journalism that dealt with the drug combo of laropiprant and niacin (not statin and niacin!). I say poor quality without hesitation because not once did the article mention that the study in question was about a drug combination therapy. The whole article pretended the research was for a single drug therapy, and this is simply false (see here for the study: http://www.nejm.org/doi/full/10.1056/NEJMoa1300955 ). In any case, false or not, the article was not right for the text in question, and this is why it needed to be changed. Zarkme ( talk) 01:56, 21 July 2014 (UTC)
There have been enough studies of various lipid treatments that meta analysis is appropriate. Basically, we don't care about lowering cholesterol with drugs or nutrients that don't change your cardiac event rate or your mortality risk. What good does it do you to die with good numbers? That's not the point. I'm even suspicious of treatments that lower cardiac event rate, if they don't at least show a trend toward lowering mortality risk. That may be a power problem, but if you don't at least see a trend toward lower mortality, it makes you wonder a lot about some compensitory bad effect. And at the very least, it means you need to treat a BOATLOAD of people to save even one life, like tens of thousands of patients for many years. At that point, it starts to look better to spend your money and time workin on people's blood pressure and the kind of car they drive, than working ot make sure they're swallowing multiple niacin pills.
In any case, the meta anaysis shows that statins, cholesterol binding resins, and fishoil have saved lives in proper studies. There's no evidence that fibrates or niacin do, yet there have been plenty of studies: PMID 15824290. In fact, niacin, fibrate and diet therapy all flunk badly, not even showing a trend.
When it comes to lowering cholesterol or triglycerides, all these treatments of course work, though they vary a great deal in what lipids they treat (fish oil and fibrates working better on triglycerides, statins on LDL, and so on). But again, who cares about fixing numbers? The cardiac event rate is way down for statins, in keeping with lower motality, as also of course for fish oil and resins. However, it's down only about 25% for fibrates and about that much also for niacin (too few studies to give confidence limits on niacin). That's why these treatments fail to show mortality drops. In fact, there's some evidence that some older fibrates (paticularly clofibrate with 25% excess mortality in a 150,000 man-years trial, see PMID 6105515) actually increase mortality. And the most commonly used fibrate (fenofibrate) used because still on-patent, has almost no long term data at all. The old gemfibrozil from VA-HIT showed a decrease in event rate but still no mortality drop, and it had equal power to most of the statin trials which did at least show mortality decrease trends. In any case, 30 trials with 4700 subjects failed to show any mortality drop in treating coronary disease with niacin: PMID 15653014. Basically niacin, and the fibrates as a class, treat lab tests. But are a bust at saving lives. I would suggest for both of them that you're treating yourself rather than your patient. But enjoy. Steve 22:59, 25 June 2006 (UTC)
Someone said that the amide form does not cause flushing... does anyone know of a reputable company that sells it that way? I have GNC multivitamins for pregnant/breastfeeding persons and it contains niacin in the amide form but finding a niacin supplement that way seems much more difficult and GNC doesn't carry it. There are several forms that niacin is sold in : nicotinic acid, nicotinamide, and Inositol Nicotinate. Which form is the most easily digestable? I'm also frustrated by labels that just say niacin! I guess they're refering to nicotinic acid. What other differences are there between those three different forms of niacin? Also, I know that it's best to drink a glass of orange juice with iron supplements... what's best to take with niacin supplements?
Can Someone add the different niacin products available: Extended release only available by Rx-as Niaspan. Others are dietary supplements offered over the counter products-Immediate release and Sustained Release. Sustained Release Niacin is associated with a higher risk of hepatotoxicity. (Can someone add this and reference it please-thanks)
Prescription is immediate or sustained. Dietary supplements claim to be either immediate or sustained, plus the weak-evidence supported "flush free" inositol hexaniacinate, which does not have a prescription match. The most often cited ref for sustained relief being higher risk of hepatotoxic is McKenney JM, et al. JAMA 1994;271(9):672-677. David notMD ( talk) 15:41, 1 June 2009 (UTC)
Good old L. Ron makes a pretty healthy mention of Niacin (The "Educated" Vitamin) in his book Clear Body, Clear Mind. It apparently sunburns people in the shape of a bathing suit. Also, it has something to do with the toxins! — Preceding unsigned comment added by 131.230.52.162 ( talk) 19:40, 21 September 2006
→ It seems to be working ok for the 9/11 rescue workers - [7] Johnalexwood 11:52, 9 October 2007 (UTC)
Someone should add something about the difference between OTC Immediate release versus OTC Extended release--thanks — Preceding unsigned comment added by 70.113.207.158 ( talk) 00:56, 29 November 2006
The words "a synthetic indole" seem out of place. D021317c 21:05, 13 December 2006 (UTC)
Note: some of these sites sell products that I can't recommend!
[8]The niacin page at Doctor Yourself.
[9]The Life Extension Foundation -- search it for niacin, Abram Hoffer, nicotinic, etc.
[10]Duane Graveline's website. See also [11]his Wikipedia page.
Search for "Hoffer" in conjunction with "niacin" for plenty of references to psychiatric and circulatory connections. As for niacin's action as a vasodilator, that's beyond controversy (and so is the role of histamine in the process). Apparently there still remains some controversy over whether it's better when trying to manage blood lipids to take a form of niacin which avoids the "niacin flush" (such as time-release forms, niacinamide, inositol hexanicotinate, etc.) or one which causes "niacin saturation" and (usually) a concomitant flush. Abram Hoffer, whose experience with niacin in large doses is utterly unparalleled, seems (to me) to be saying that only pure niacin (nicotinic acid) is effective, and if I read him correctly, the flush is unavoidable. Don't confuse the lipid-altering with the psychiatric therapies. Though schizophrenia has been treated with niacinamide (avoiding the flush), it has also been suspected of increasing the incidence of depression. D021317c 22:35, 13 December 2006 (UTC)
If I take Naicin/ vitamin B am I taking nicotinamide? Should I avoid Niacin to live longer? The following article indicates that nicotinamide binds the sirtuin molecule to inhibit its activity.
In recent years, scientists have discovered that a family of enzymes called sirtuins can dramatically extend life in organisms as diverse as yeast, worms, and flies. They may also be able to control age-associated metabolic disorders, including obesity and type II diabetes. ( http://www.wistar.org) Using the techniques of structural biology, the Wistar team demonstrated that a component(nicotinamide) of the common vitamin B3, also known as niacin, binds to a specific site on the sirtuin molecule to inhibit its activity. -- Oxy49 21:09, 18 February 2007 (UTC)
In the article, it mentions a person taking 36 capsules containing 500 decagram of niacin. 36x500=18000 decagram, or 180 kg. Of course this is incorrect, please rectify.
some sort of advertising thrown in^
should be changed to: most energy drinks and beer (yes beer has b vitamins)
it says the effects can be mediated by taking 0.3mg of aspirin. Shouldn't that be 300mg or 0.3g?
http://www.tylermedicalclinic.com/Baby%20Aspirin.htm Normal aspirin dosage is 300-1000mg (see aspirin dosage @ wiki) I agree this needs to be changed. LucidWay 15:03, 9 July 2007 (UTC)
I really wish that this article would cite the differences between nicotinic acid and nicotinamide. I've read some really interesting and simple articles on the internet that list the differences. Nicotinic acid helps reduce lipid levels while nicotinimide doesn't. There are several other differences... and it looks like there are some far more knowledgable people who could have written this article based on all the discussion. One more thing,what's Inositol Nicotinate? Some stores are selling this labeled as niacin. There's a difference between those 2 niacin supplements although most stores still label them both as simply niacin. What's the diffenrence with Inositol Nicotinate?
Just got back from GNC. What is niacinamide? Is it related to nicotinamide?
The first line being about Niacin being a treatment for Pelagra is inappropriate. I'm sure someone took the line right out of the television show, "House" (I just watched the episode, where they say this, near word for word). Just because someone hears this on a TV show, even if it's true, does NOT mean it should be in the first sentence of an article. I'm sure that someone watched House, and typed this in here thinking that that's all Niacin did. We don't say "Vitamin D is a treatment for ricketts" do we?
I won't change it, because I'll admit that my writing skills aren't top notch, but it should be changed and moved elsewhere, significance in an article should not be dictated by a TV show. Sirhodges ( talk) 22:28, 20 September 2008 (UTC)
"The terms niacin, nicotinamide, and vitamin B3 are often used interchangeably to refer to any one of this family of molecules, since they have a common biochemical activity." That statement, which I can't believe is correct, condones, promotes, and misstates sloppy speaking. It doesn't belong anywhere in the article, much less in the introduction. The simple facts are that "niacin" is synonymous with "nicotinic acid," "niacinamide" is synonymous with "nicotinamide," and that "vitamin B3" usually refers indiscriminately to either of them or to both. Nobody who understands those relationships would refer to nicotinic acid as "niacinamide"!
Incidentally, I disagree with Sirhodges's paragraph above. I know nothing about the television show, but that niacin administration is the ideal cure for niacin deficiency, which manifests itself as pellagra, is incontrovertible. It is the main use of niacin in medicine, and of the highest significance. Until recently, that was its only significance. Unfree ( talk) 20:24, 28 November 2008 (UTC)
The picture with the two-step oxidation of tryptophan is total BS. At least in humans, the only enzyme that handles niacin as in- or output is Nicotinate phosphoribosyltransferase (EC 2.4.2.11). Also the reference which is stated to support the claim that the body can make 1 mg niacin out of 60 mg tryptophan itself criticizes the claim and gives counterervidence.
That means niacin is totally essential. What is semi-essential, however, is the NAD biosynthesis, as there tryptophan catabolism provides chinolinic acid as precursor which is similiar enough to niacin and nicotinamide to give a second pathway to NAD in case there's no niacin nor niacinamide. But tryptophan is essential, too, so NAD-deficiency is possible. -- Ayacop ( talk) 18:01, 8 January 2009 (UTC)
I am sure I have read somewhere that, while niacin is in the B group of vitamins, it should no longer be called Vitamin B3.I do not wish to change the article though, as I am not a dietitian. ACEOREVIVED ( talk) 22:30, 17 March 2009 (UTC)
Chart suggestion for vitamins and minerals.
Having been in business with a herbal department, there appears to be a need for a standardized presentation of vitamins and minerals to provide handy information to the general public.
Suggestion the following graph, if someone with this ability can present it as so.
Recommend a stardaized chart. Top lines, recommended daily allowance.
Then prioritized items that provide the element, together with amount of item in each serving and a percentage of the recommended daily allowance.
Why?
Well say vitamin C. One glass of orange juice. 100%
Vitamin D. One egg, 20. 3%
At the bottom of the chart important co ingredients required, and or negative factors to absorption.
Percentage of daily allowance per serving of food is a necessity.
Niacin is listed as an ingredient in K-Y brand Intense arousal gel. I can only speculate that it is an active ingredient. If so, should this article include this fact and niacin's role in the gel? It is probably associated with niacin flush breifly mentioned in the article. Prometheus-X303- 01:52, 18 July 2009 (UTC)
Yes, it is used as an active. The flushing effect on ingestion is supposed to have a similar effect when applied to the clitoris - bringing blood flow to the clitoris, a warming sensation (Glycerine/Glycerol has this effect anyway) and possibly engorgment. Whether or not it does indded do this, is highly debateable. (Non-User:Rob) —Preceding unsigned comment added by 124.198.147.186 ( talk) 01:43, 27 August 2009 (UTC)
Should this section be removed? It's poorly written and not sourced. I haven't been able to find any respectable sources for substitutes for niacin in cases of allergies. —Preceding unsigned comment added by ArrogantJerk ( talk • contribs) 06:13, 25 October 2009 (UTC)
{{Multiple issues |unencyclopedic = January 2009 |POV = January 2009 |disputed=November 2008} } It would be great to cleanup the article by addressing open issues regarding the Niacin#Pharmacological uses section. As shown above, the dispute goes back to 2008 - since that time, new studies have been published. Can anyone state what the issues are (it wasn't clear, as comments on this talk page related to Pharmacological uses seem rather old). Thanks, -- 4wajzkd02 ( talk) 14:45, 20 November 2009 (UTC)
This is my first wiki entry: excuse it's illiteracy, the page is nice. in the: Biosynthesis and chemical synthesis, the first graphic titled "Biosynthesis: Tryptophan → kynurenine → niacin" the tryp. molecule is has two too many hydrogens or 1 too few double bonds : http://upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Niacin_biosynthesis.svg/400px-Niacin_biosynthesis.svg.png compare with: http://en.wikipedia.org/wiki/Tryptophan thanks for the article :)
--- This article is a mess. —Preceding unsigned comment added by 93.136.47.83 ( talk) 16:09, 1 March 2010 (UTC)
I deleted what i think was an overexplanation of the term nixtamalization. The link to the article should be used if further information regarding that term is wanted, otherwise topic would be lost among a host of lenghty intraarticle definitions.
WonderingAngel-aesc78 ( talk) 01:35, 25 May 2010 (UTC)
Deleted 3 lines explaining flushing to avoid clutter and deviation from main article. Term is already linked for its further explanation.
WonderingAngel-aesc78 ( talk) 02:36, 25 May 2010 (UTC)
I'm deleting the obvious ads for Niaspan. We'll see how long they stay off.
Echo5Joker ( talk) 11:30, 11 July 2010 (CST)
Niacin appears frequently in food ingredient lists: sometimes it is probably a vitamin supplement - but other sources say it is a "color retention agent". I am having trouble finding info about its use as a color retention agent. It would be awesome if someone knowledgeable were to add a section about this. —Preceding unsigned comment added by 99.63.211.181 ( talk) 04:15, 12 October 2010 (UTC)
I removed this image because the central chemical structure (kynurenine) is incorrect. It is missing one of the double bonds in the phenyl ring. —Preceding unsigned comment added by 96.227.89.95 ( talk) 00:15, 29 October 2010 (UTC)
here: http://www.ajcn.org/content/4/4/313.full.pdf György refered to vitamin B2 as the antipellagra factor !???? Trente7cinq ( talk) 15:16, 11 March 2011 (UTC)
This article needs additional citations for
verification. |
“ | One recommended daily allowance of niacin is 2–12 mg/day for children, 14 mg/day for women, 16 mg/day for men, and 18 mg/day for pregnant or breast-feeding women. [12] The upper limit for adult men and women is 35 mg/day, which is based on flushing as the critical adverse effect. citation needed | ” |
— Niacin, dead link |
Removed unsourced material Outelligent ( talk) 00:33, 6 August 2011 (UTC)
Maybe you can add it back, as the link #29 (Jacobson, EL (2007). "Niacin". Linus Pauling Institute. Retrieved 2008-03-31: http://lpi.oregonstate.edu/infocenter/vitamins/niacin/) has all the info (for both daily needs, as well as daily max). Here is the cit #29: [13]
I think that the first part needs revision. It says that "niacin is also known as Vitamin B3" but I have a book which says that this is no longer called Vitamin B3. It might be written on bottles and boxes that it is, but that does not make it right! Any one who knows about these things could change the opening sentence. ACEOREVIVED ( talk) 16:58, 13 March 2012 (UTC)
This link isn't a source but it references an source that seems reliable. It says 900 mg for adults. Sorry, I'm not a doctor or something. I just think the 35 mg/day is unbelievable. — Preceding unsigned comment added by 80.98.231.58 ( talk) 05:11, 17 September 2012 (UTC)
Also in developed countries mild forms of Pellagra are much common. I know this because I suffered more than 10 years from it. It took me those 10 years how to become healthy again, to find out that I need niacin! For treatment I take 2 doses with 1,5g niacin everyday, and my chronique fatigue and also my skin problems just went away. So flushing is joyful, it's like an immun reaction and makes you healthy. I would appreciate if other people who experienced mild forms of Pellagra would help to improve this article. 178.197.225.71 ( talk) 11:41, 21 August 2013 (UTC)
"Some of these symptoms are generally related to niacin's role as the rate limiting cofactor in the histidine decarboxylase enzyme which converts l-histidine into histamine." - So you know now what patients suffering from histamine intolerance need. -- 178.197.227.26 ( talk) 12:17, 21 August 2013 (UTC)
Noticed this in the Deficiency section:
Patients with alcoholism typically experience increased intestinal permeability, leading to negative health outcomes.
The reference seems to be gone, and the study that was linked previously didn't imply the conclusion made in this statement. It isn't really relevant to an article on niacin deficiency, it seems like "leaky gut syndrome" propaganda. — Preceding unsigned comment added by Tsunami3 ( talk • contribs) 23:10, 2 December 2013 (UTC)
http://www.nejm.org/doi/full/10.1056/NEJMoa1300955?query=featured_home
Wawot1 ( talk) 23:14, 17 July 2014 (UTC)
Just want to throw some cold water on the media stories re. Niacin that have appeared in the last few days. The reporting re Niacin has been erroneous in the popular press. CBC was the worst - it didn't once mention that the study in question dealt with a drug combination. Thw whole article just pretended the study only dealth with Niacin in isolation. This means that side effects of "Laropiprant" could easily be being mis-attributed to Niacin erroneously in the popular press.
So I just want to head things off and warn editors to be careful that the evidence is to date only conclusive in showing that a drug combination has adverse effects, and it cannot be so simply attributed to Niacin until more research is done.
Unfortunately I have been unable to find much info on side effects of laropiprant on its own.. it appears to be poorly studied in isolation. I get a lot of things like "Insufficient information available about LAROPIPRANT for xyz".
I want to point out:
Some quotes:
And of course, some examples of the stories / media beatups:
I'm not very good with wikipedia etiquette so sorry in advance if I am in error somehow.. Zarkme ( talk) 10:11, 18 July 2014 (UTC)
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