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This page is full of scandel trigger bait - not up to standards one would expect from an encyclopedia. Some of the readers are more interested in if it might be helpful (no longer patentable - thus not a research candidate in the USA ). This medicine may be effective for heart disease - nephropathy etc. As a potential treatment drug it is VERY interesting - not that anyone will see this from this poor quality page.
In the USA, if a drug is banned for use by athletes, or is illegal, it's because it can be damaging to the person taking it. In other words, because it could be fatal. Nowhere does this Wikipedia entry for Meldonium discuss the dangers of taking this drug. Any medication has at least one mild negative side effect. People who have contributed to this page seem to have decided that publicizing any negative side effects of this drug would hurt the sales of this drug.
I can see a short section on the sports ban - but there are more important things pushed out. What if this drug is actually more effective than the statins commonly prescribed? What if the effects on the NO system really matter?. There is material in research about this drug - might be a wonder drug hiding out in the Russian block - not used in the USA due to politics and ignorance. — Preceding unsigned comment added by 108.243.106.82 ( talk) 19:44, 9 August 2020 (UTC)
Can a suitably knowledgeable expert editor add a section explaining how this drug can be used to enhance athletic performance? -- Ef80 ( talk) 20:47, 7 March 2016 (UTC)
"In the mitochondria, the effects of the carnitine shuttle are reduced by meldonium, which competitively inhibits the SLC22A5 transporter. This results in reduced transportation and metabolism of long-chain fatty acids in the mitochondria (this burden is shifted more to peroxisomes). The final effect is a decreased risk of mitochondrial injury from fatty acid oxidation and a reduction of the production of acylcarnitines, which has been implicated in the development of insulin resistance.[9][10] Because of its inhibitory effects on L-carnitine biosynthesis and its subsequent glycolytic effects as well as reduced acylcarnitine production, meldonium has been indicated for use in diabetic patients. Long term use has been shown to reduce blood glucose concentrations, exhibit cardioprotective effects and prevent or reduce the severity of diabetic complications.[11] Long term treatment has also been shown to attenuate the development of atherosclerosis in the heart."
Could someone add to this article why this drug was added to the World Anti-Doping Agency's banned list? What exactly would this drug be used for to enhance performance? Kingturtle = ( talk) 22:05, 7 March 2016 (UTC)
Why does the article cite a study that it improved performance, then says "nevertheless", WADA banned the drug. Seems like this modifier only works if the results of that study were opposite. Perhaps we should edit out that word, or change it to "accordingly", or something? — Preceding unsigned comment added by 169.234.214.202 ( talk) 07:16, 9 March 2016 (UTC)
A New York Times opinion piece says about meldonium: "The World Anti-Doping Agency banned the drug because it helps athletes by delivering more oxygen to muscles." The article cited in the Doping section ("A December 2015 study in the journal Drug Testing and Analysis argued that meldonium "demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection against stress, and enhanced activations of central nervous system (CNS) functions".[38]") is an article about a method for measuring the drug or its metabolites. The article asserts in its conclusions section that meldonium "is known to have a positive effect on the endurance performance of athletes," but no reference for this statement is provided. Meldonium is an inhibitor of fatty acid beta-oxidation. Beta-oxidation produces NADH, which drives oxidative phosphorylation. It makes no sense that this drug enhances performance in any activity that requires ATP. Athletes may be using meldonium because they think it enhances performance, but what if meldonium is, instead, decreasing performance? Can anyone provide the reference to a scientific study that demonstrates meldonium increases performance? Rdphair ( talk) 01:05, 12 March 2016 (UTC)
The reference to the Bayer AG company lobbying WADA only has a reference to the Bayer wiki page. Seems like this needs citation. Anyone? (sorry for the anon) 68.43.112.179 ( talk) 15:05, 12 March 2016 (UTC)
I read an article in the L.A. Times that quotes a doctor saying very negative things about the medicinal use of this drug. To wit: "I can tell you that in my roughly 18 years of practicing medicine, not once have I nor my medical colleagues ever prescribed this medication. It has no robust, randomized trials to support its clinical use from a cardiac perspective..." and so on. Howver, this Wikipedia article says only really, really good things about the medicinal uses. I've thereofre tagged that section as possibly non-neutral, given the quote of a likely reputable doctor and the oposite statements in the article. This probably requires the help of someone in the medicine field. HappyValleyEditor ( talk) 05:36, 8 March 2016 (UTC)
Meldonium is believed to exert its cardioprotective effects through its ability to cause vasodilation in the coronary arteries via increased nitric oxide synthesis, reducing blood glucose concentrations through increased oxidation of glucose and also by preconditioning the heart to handle ischaemic situations, among other effects. It also has been used to treat cerebral ischaemia. This is all done through its inhibition of carnitine synthesis.
Where does this come from? The vasodilation claim is probably only from the meldonium-author himself and the vasodilation connection with carnitine is complete and utter nonsense. Carnitine himself is a vasodilator, if you block it's synthesis, then there will be the opposing effect! I suggest to delete this part completely. -- 2A02:908:1964:BCA0:E9D4:8C2E:775C:FF91 ( talk) 15:13, 17 October 2017 (UTC)
Need someone to expand on this idea. Similar to insulin? In which ways? Does someone care to elaborate on this or cite sources where the two are compared? — Preceding unsigned comment added by Aglo123 ( talk • contribs) 12:31, 8 March 2016 (UTC)
What is the "ME3" in the molecular diagram? Maybe this should be changed to a more standard looking diagram. — Preceding unsigned comment added by 2001:4898:80E8:C:0:0:0:3E9 ( talk) 15:04, 8 March 2016 (UTC)
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Cheers.— cyberbot II Talk to my owner:Online 06:56, 9 March 2016 (UTC)
Change the infobox into {{ Drugbox}}? It's a medicine, could use clinical data etc. - DePiep ( talk) 10:12, 9 March 2016 (UTC)
Hm. This is becoming a bit political. Some people in Russia claiming that this is a Western attempt at sanctions due to political differences (see: [2], claim that the initiative to ban it started in the US), that this is "as ridiculous as banning aspirin". There's currently a scandal in Russia, as apparently the bureaucrats who should've objected to the banning of the drug on the international forum failed to do their job, and didn't take part in the debates at all, leading to an uncontested decision to ban it: [3]. Also, interesting Russian-language interview with a manufacturer of the drug here: [4], and French-language interview in Le Monde with the inventor, who steadfastly claims that "it's not a doping drug": [5]. Esn ( talk) 07:57, 10 March 2016 (UTC)
I find it ironic that posters here state that the drug is not picked up by the FDA because it has no efficacy but yet the US bans the drug "because of evidence of its use by athletes with the intention of enhancing performance." This whole deal smells very fishy! SChalice 16:42, 8 June 2016 (UTC)
I didn't see this specific article used in Wiki, so I'm adding it in case it comes in handy. It contains some information that may help with the evaluation of inventor's medical claims and MEDRS: https://edition.cnn.com/2016/03/21/health/maria-sharapova-drug-meldonium-cold-war-origins/index.html KC LV ( talk) 11:33, 21 February 2018 (UTC)
I removed the following sentence from the doping section of the article because: (1) the source is no longer working (404 error) (2) the sentence is vague (banned by who?) (3) it contradicts one of the major examples which is in Tennis in which it was banned in 2016
"Based on the overall effects these drugs have, they have been banned since 2001 from men's competitions and 2005 for women's. ref: S4 Hormone and metabolic modulators. Antidoping Switzerland."
This is the
talk page for discussing improvements to the
Meldonium article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find sources: Google ( books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL |
![]() | This article is rated C-class on Wikipedia's
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This page is full of scandel trigger bait - not up to standards one would expect from an encyclopedia. Some of the readers are more interested in if it might be helpful (no longer patentable - thus not a research candidate in the USA ). This medicine may be effective for heart disease - nephropathy etc. As a potential treatment drug it is VERY interesting - not that anyone will see this from this poor quality page.
In the USA, if a drug is banned for use by athletes, or is illegal, it's because it can be damaging to the person taking it. In other words, because it could be fatal. Nowhere does this Wikipedia entry for Meldonium discuss the dangers of taking this drug. Any medication has at least one mild negative side effect. People who have contributed to this page seem to have decided that publicizing any negative side effects of this drug would hurt the sales of this drug.
I can see a short section on the sports ban - but there are more important things pushed out. What if this drug is actually more effective than the statins commonly prescribed? What if the effects on the NO system really matter?. There is material in research about this drug - might be a wonder drug hiding out in the Russian block - not used in the USA due to politics and ignorance. — Preceding unsigned comment added by 108.243.106.82 ( talk) 19:44, 9 August 2020 (UTC)
Can a suitably knowledgeable expert editor add a section explaining how this drug can be used to enhance athletic performance? -- Ef80 ( talk) 20:47, 7 March 2016 (UTC)
"In the mitochondria, the effects of the carnitine shuttle are reduced by meldonium, which competitively inhibits the SLC22A5 transporter. This results in reduced transportation and metabolism of long-chain fatty acids in the mitochondria (this burden is shifted more to peroxisomes). The final effect is a decreased risk of mitochondrial injury from fatty acid oxidation and a reduction of the production of acylcarnitines, which has been implicated in the development of insulin resistance.[9][10] Because of its inhibitory effects on L-carnitine biosynthesis and its subsequent glycolytic effects as well as reduced acylcarnitine production, meldonium has been indicated for use in diabetic patients. Long term use has been shown to reduce blood glucose concentrations, exhibit cardioprotective effects and prevent or reduce the severity of diabetic complications.[11] Long term treatment has also been shown to attenuate the development of atherosclerosis in the heart."
Could someone add to this article why this drug was added to the World Anti-Doping Agency's banned list? What exactly would this drug be used for to enhance performance? Kingturtle = ( talk) 22:05, 7 March 2016 (UTC)
Why does the article cite a study that it improved performance, then says "nevertheless", WADA banned the drug. Seems like this modifier only works if the results of that study were opposite. Perhaps we should edit out that word, or change it to "accordingly", or something? — Preceding unsigned comment added by 169.234.214.202 ( talk) 07:16, 9 March 2016 (UTC)
A New York Times opinion piece says about meldonium: "The World Anti-Doping Agency banned the drug because it helps athletes by delivering more oxygen to muscles." The article cited in the Doping section ("A December 2015 study in the journal Drug Testing and Analysis argued that meldonium "demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection against stress, and enhanced activations of central nervous system (CNS) functions".[38]") is an article about a method for measuring the drug or its metabolites. The article asserts in its conclusions section that meldonium "is known to have a positive effect on the endurance performance of athletes," but no reference for this statement is provided. Meldonium is an inhibitor of fatty acid beta-oxidation. Beta-oxidation produces NADH, which drives oxidative phosphorylation. It makes no sense that this drug enhances performance in any activity that requires ATP. Athletes may be using meldonium because they think it enhances performance, but what if meldonium is, instead, decreasing performance? Can anyone provide the reference to a scientific study that demonstrates meldonium increases performance? Rdphair ( talk) 01:05, 12 March 2016 (UTC)
The reference to the Bayer AG company lobbying WADA only has a reference to the Bayer wiki page. Seems like this needs citation. Anyone? (sorry for the anon) 68.43.112.179 ( talk) 15:05, 12 March 2016 (UTC)
I read an article in the L.A. Times that quotes a doctor saying very negative things about the medicinal use of this drug. To wit: "I can tell you that in my roughly 18 years of practicing medicine, not once have I nor my medical colleagues ever prescribed this medication. It has no robust, randomized trials to support its clinical use from a cardiac perspective..." and so on. Howver, this Wikipedia article says only really, really good things about the medicinal uses. I've thereofre tagged that section as possibly non-neutral, given the quote of a likely reputable doctor and the oposite statements in the article. This probably requires the help of someone in the medicine field. HappyValleyEditor ( talk) 05:36, 8 March 2016 (UTC)
Meldonium is believed to exert its cardioprotective effects through its ability to cause vasodilation in the coronary arteries via increased nitric oxide synthesis, reducing blood glucose concentrations through increased oxidation of glucose and also by preconditioning the heart to handle ischaemic situations, among other effects. It also has been used to treat cerebral ischaemia. This is all done through its inhibition of carnitine synthesis.
Where does this come from? The vasodilation claim is probably only from the meldonium-author himself and the vasodilation connection with carnitine is complete and utter nonsense. Carnitine himself is a vasodilator, if you block it's synthesis, then there will be the opposing effect! I suggest to delete this part completely. -- 2A02:908:1964:BCA0:E9D4:8C2E:775C:FF91 ( talk) 15:13, 17 October 2017 (UTC)
Need someone to expand on this idea. Similar to insulin? In which ways? Does someone care to elaborate on this or cite sources where the two are compared? — Preceding unsigned comment added by Aglo123 ( talk • contribs) 12:31, 8 March 2016 (UTC)
What is the "ME3" in the molecular diagram? Maybe this should be changed to a more standard looking diagram. — Preceding unsigned comment added by 2001:4898:80E8:C:0:0:0:3E9 ( talk) 15:04, 8 March 2016 (UTC)
Hello fellow Wikipedians,
I have just added archive links to one external link on
Meldonium. Please take a moment to review
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Cheers.— cyberbot II Talk to my owner:Online 06:56, 9 March 2016 (UTC)
Change the infobox into {{ Drugbox}}? It's a medicine, could use clinical data etc. - DePiep ( talk) 10:12, 9 March 2016 (UTC)
Hm. This is becoming a bit political. Some people in Russia claiming that this is a Western attempt at sanctions due to political differences (see: [2], claim that the initiative to ban it started in the US), that this is "as ridiculous as banning aspirin". There's currently a scandal in Russia, as apparently the bureaucrats who should've objected to the banning of the drug on the international forum failed to do their job, and didn't take part in the debates at all, leading to an uncontested decision to ban it: [3]. Also, interesting Russian-language interview with a manufacturer of the drug here: [4], and French-language interview in Le Monde with the inventor, who steadfastly claims that "it's not a doping drug": [5]. Esn ( talk) 07:57, 10 March 2016 (UTC)
I find it ironic that posters here state that the drug is not picked up by the FDA because it has no efficacy but yet the US bans the drug "because of evidence of its use by athletes with the intention of enhancing performance." This whole deal smells very fishy! SChalice 16:42, 8 June 2016 (UTC)
I didn't see this specific article used in Wiki, so I'm adding it in case it comes in handy. It contains some information that may help with the evaluation of inventor's medical claims and MEDRS: https://edition.cnn.com/2016/03/21/health/maria-sharapova-drug-meldonium-cold-war-origins/index.html KC LV ( talk) 11:33, 21 February 2018 (UTC)
I removed the following sentence from the doping section of the article because: (1) the source is no longer working (404 error) (2) the sentence is vague (banned by who?) (3) it contradicts one of the major examples which is in Tennis in which it was banned in 2016
"Based on the overall effects these drugs have, they have been banned since 2001 from men's competitions and 2005 for women's. ref: S4 Hormone and metabolic modulators. Antidoping Switzerland."