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It's more precisely descriptive to use scientific language when discussing chemical structure and actions. Lynxx2 ( talk) 15:44, 4 June 2016 (UTC)
The page Hyperhomocysteinemia already exists and has some overlapping information with this page. It may be more appropriate to move anything related to elevated homocysteine to the Hyperhomocysteinemia page. Manfred Bartz ( talk) 12:19, 9 January 2013 (UTC)
Could be most cases are sub-clinical Hypothyroidism? —Preceding unsigned comment added by 63.245.153.165 ( talk) 03:19, 29 November 2009 (UTC)
Waster ( talk · contribs) inserted the news item that taking B vitamins was not helpful. This has not been published yet - it was an abstract at the European Society of Cardiology, presented on 5/9/2005 by Bonaa KH et al [1] [2]. I think we should scan the literature in a few months to see which large journal will be publishing this finding. JFW | T@lk 16:58, 6 September 2005 (UTC)
This is incomprehensible:
As B12 is inefficiently absorbed from food by elderly persons they could gain a greater benefit from taking vitamin supplements.
Greater than from what? Which of the mentioned vitamins? -- Espoo 20:11, 20 June 2006 (UTC)
The above statement is not really a true statement, in addition to being incomprehensible. The decline in absorption of B12 from the stomach is generally believed to be due to lower levels of intrinsic factor being produced by stomach cells. Intrinsic factor, a protein, is essential to absorption of B12 through the stomach lining. So B12 via food and via vitamin supplementation will both be blocked by the lack of intrinsic factor. The traditional way around this is to inject intramuscularly B12. As I recall, Scandanavians have been shown to be low in intrinsic factor especially, as well as older people in general. (Hey, I'm just getting used to this. Haven't figured out the 'Sandbox' yet.) Siam442 ( talk) 23:40, 24 February 2009 (UTC)
"Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics." by Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, Formenti S, De Franchis R, Vecchi M.; Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Maggiore Hospital and University of Milan, Milan, Italy.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15952099&dopt=Abstract
PMID: 15952099 [PubMed - indexed for MEDLINE]
--
Renice
05:11, 24 March 2007 (UTC)
I do believe there is a possible link between homocysteine levels and dementia. Does anyone want to verify and add this? Kenkoo1987 01:45, 1 November 2006 (UTC)
Connection with dementia and other neurodegenerative diseases?
"Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency" by Jonathan D Picker, MBChB, PhD; Harvey L Levy, MD
[just holding this here until someone can incorporate relevant bits]
--
Renice
05:58, 24 March 2007 (UTC)
if homocysteine is not obtained from diet as the article claims and homocysteine forms methionine, how can methionine be an essential amino acid? -- Bubbachuck ( talk) 09:14, 13 January 2008 (UTC)
Hi, This article erroneously states; "No study has yet been conducted in a preventive capacity on subjects who are in a relatively good state of health."
Three such peer reviewed papers reporting on intervention trials are im medline,
PMID: 15086356 PMID: 10683000 PMID: 19118243 are the ID numbers at pubmed the online portal. As of Jan '09 these may be the only three and all report benefits for hi dose, homocysteine reducing supplementation.
04:54, 10 January 2009 (UTC)Thomas Carter04:54, 10 January 2009 (UTC) 67.235.35.232 ( talk)
I am a 40 year male (Indian - Punjab) and last week experienced a stroke. I felt serious numbness in my right limbs and lost control of the right side of my mouth. I could not talk properly and rushed immediately to the hospital. I was lucky and recovered.
The Docs say there was a very small clot in the brain (the report says - MRI done showed, old infract in the left cerebellar hemisphere with subtle hyper intensity seen inthe left frontal region...).
On testing found everything within limits except for HOmocysteine - which recorder at 74.15 umol / L.
Could this be the reason for the clot in my head?
I work out at the gym 2 hours daily, could heavy exercise give rise to higher levels of homocysteine? I dont want to leave going to the gym.
I would appreciate all who can advice me on further course of action.
Thank you
Parminder.B.Singh parminderbsingh@yahoo.co.in —Preceding unsigned comment added by 121.245.79.251 ( talk) 16:55, 9 July 2009 (UTC)
Please do not seek medical advice on Wikipedia. Tony (talk) 12:47, 28 May 2010 (UTC)
Try to lower HCy, get cancer risk increase instead http://jama.ama-assn.org/cgi/content/abstract/302/19/2111 JFW | T@lk 22:59, 17 November 2009 (UTC)
The list of references needs a good copy-edit. Some refs have inadequate information as well as inconsistent formatting. And the rest of the article could do with updating. Tony (talk) 12:45, 28 May 2010 (UTC)
The opening sentence declares that homocysteine is a non-protein amino acid. Reading this I'm not sure what it means. Is it that this amino acid (one of "the building blocks of protein") doesn't occur in proteins, doesn't occur in the usual proteins (whatever that set may be) or cannot occur in proteins? Does it mean something else, perhaps that homocysteine has a "non-protein role" in the body? Could someone who knows expand the shorthand "non-protein" to say exactly what is meant? 78.144.77.146 ( talk) 11:23, 31 July 2013 (UTC)
"A high level of homocysteine makes a person more prone to endothelial injury, which leads to vascular inflammation, which in turn may lead to atherogenesis... " should that really say atherogenesis, or are we referring to atherosclerosis? 24.21.86.182 ( talk) 18:44, 1 September 2013 (UTC)
Section added since Homocystine redirects here and is not in fact the same chemical. This is s 'stop gap' to avoid misinformation. A better reference is needed as is mention of homocystinuria. Homocystine probably is not important enough to warrant it's own page. Leopardtail ( talk) 18:35, 27 May 2014 (UTC)
I noticed there was a request for documentation or citation on normal homocystine levels.
I couldn't find anything from the Framingham study that discussed this straight out, despite being implied.
But the numbers seem correct.
I think this might be a valuable link http://www.emedicinehealth.com/homocysteine/page4_em.htm
If so you can add the citation and adjust the test.
Hope this helps — Preceding unsigned comment added by Cdmphy ( talk • contribs) 22:46, 7 April 2016 (UTC)
The comment(s) below were originally left at Talk:Homocysteine/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
The Table containing limits of Homocysteine has two different values for Female>60 years. The recommended values for Males >60years is missing. Obviously there is a simple error. The author may be contacted to correct the error.
|
Last edited at 17:42, 26 November 2008 (UTC). Substituted at 18:12, 29 April 2016 (UTC)
HomocystIne redicts to this page, and one part refers to HomocystIne as if it were an alternative spelling.
HomocystIne is however a compound formed of two HomocystEIne molecules with a disuplhide bond. This page either needs section covering Homocystine (not ideal) or the page for that molecule needs to be restored. -- Leopardtail ( talk) 13:48, 21 May 2017 (UTC)
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Why does the atherogenesis link near the top bring up atherosclerosis in the mouse over? 4.36.46.138 ( talk) 17:01, 9 July 2024 (UTC)
![]() | This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Homocysteine.
|
It's more precisely descriptive to use scientific language when discussing chemical structure and actions. Lynxx2 ( talk) 15:44, 4 June 2016 (UTC)
The page Hyperhomocysteinemia already exists and has some overlapping information with this page. It may be more appropriate to move anything related to elevated homocysteine to the Hyperhomocysteinemia page. Manfred Bartz ( talk) 12:19, 9 January 2013 (UTC)
Could be most cases are sub-clinical Hypothyroidism? —Preceding unsigned comment added by 63.245.153.165 ( talk) 03:19, 29 November 2009 (UTC)
Waster ( talk · contribs) inserted the news item that taking B vitamins was not helpful. This has not been published yet - it was an abstract at the European Society of Cardiology, presented on 5/9/2005 by Bonaa KH et al [1] [2]. I think we should scan the literature in a few months to see which large journal will be publishing this finding. JFW | T@lk 16:58, 6 September 2005 (UTC)
This is incomprehensible:
As B12 is inefficiently absorbed from food by elderly persons they could gain a greater benefit from taking vitamin supplements.
Greater than from what? Which of the mentioned vitamins? -- Espoo 20:11, 20 June 2006 (UTC)
The above statement is not really a true statement, in addition to being incomprehensible. The decline in absorption of B12 from the stomach is generally believed to be due to lower levels of intrinsic factor being produced by stomach cells. Intrinsic factor, a protein, is essential to absorption of B12 through the stomach lining. So B12 via food and via vitamin supplementation will both be blocked by the lack of intrinsic factor. The traditional way around this is to inject intramuscularly B12. As I recall, Scandanavians have been shown to be low in intrinsic factor especially, as well as older people in general. (Hey, I'm just getting used to this. Haven't figured out the 'Sandbox' yet.) Siam442 ( talk) 23:40, 24 February 2009 (UTC)
"Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics." by Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, Formenti S, De Franchis R, Vecchi M.; Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Maggiore Hospital and University of Milan, Milan, Italy.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15952099&dopt=Abstract
PMID: 15952099 [PubMed - indexed for MEDLINE]
--
Renice
05:11, 24 March 2007 (UTC)
I do believe there is a possible link between homocysteine levels and dementia. Does anyone want to verify and add this? Kenkoo1987 01:45, 1 November 2006 (UTC)
Connection with dementia and other neurodegenerative diseases?
"Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency" by Jonathan D Picker, MBChB, PhD; Harvey L Levy, MD
[just holding this here until someone can incorporate relevant bits]
--
Renice
05:58, 24 March 2007 (UTC)
if homocysteine is not obtained from diet as the article claims and homocysteine forms methionine, how can methionine be an essential amino acid? -- Bubbachuck ( talk) 09:14, 13 January 2008 (UTC)
Hi, This article erroneously states; "No study has yet been conducted in a preventive capacity on subjects who are in a relatively good state of health."
Three such peer reviewed papers reporting on intervention trials are im medline,
PMID: 15086356 PMID: 10683000 PMID: 19118243 are the ID numbers at pubmed the online portal. As of Jan '09 these may be the only three and all report benefits for hi dose, homocysteine reducing supplementation.
04:54, 10 January 2009 (UTC)Thomas Carter04:54, 10 January 2009 (UTC) 67.235.35.232 ( talk)
I am a 40 year male (Indian - Punjab) and last week experienced a stroke. I felt serious numbness in my right limbs and lost control of the right side of my mouth. I could not talk properly and rushed immediately to the hospital. I was lucky and recovered.
The Docs say there was a very small clot in the brain (the report says - MRI done showed, old infract in the left cerebellar hemisphere with subtle hyper intensity seen inthe left frontal region...).
On testing found everything within limits except for HOmocysteine - which recorder at 74.15 umol / L.
Could this be the reason for the clot in my head?
I work out at the gym 2 hours daily, could heavy exercise give rise to higher levels of homocysteine? I dont want to leave going to the gym.
I would appreciate all who can advice me on further course of action.
Thank you
Parminder.B.Singh parminderbsingh@yahoo.co.in —Preceding unsigned comment added by 121.245.79.251 ( talk) 16:55, 9 July 2009 (UTC)
Please do not seek medical advice on Wikipedia. Tony (talk) 12:47, 28 May 2010 (UTC)
Try to lower HCy, get cancer risk increase instead http://jama.ama-assn.org/cgi/content/abstract/302/19/2111 JFW | T@lk 22:59, 17 November 2009 (UTC)
The list of references needs a good copy-edit. Some refs have inadequate information as well as inconsistent formatting. And the rest of the article could do with updating. Tony (talk) 12:45, 28 May 2010 (UTC)
The opening sentence declares that homocysteine is a non-protein amino acid. Reading this I'm not sure what it means. Is it that this amino acid (one of "the building blocks of protein") doesn't occur in proteins, doesn't occur in the usual proteins (whatever that set may be) or cannot occur in proteins? Does it mean something else, perhaps that homocysteine has a "non-protein role" in the body? Could someone who knows expand the shorthand "non-protein" to say exactly what is meant? 78.144.77.146 ( talk) 11:23, 31 July 2013 (UTC)
"A high level of homocysteine makes a person more prone to endothelial injury, which leads to vascular inflammation, which in turn may lead to atherogenesis... " should that really say atherogenesis, or are we referring to atherosclerosis? 24.21.86.182 ( talk) 18:44, 1 September 2013 (UTC)
Section added since Homocystine redirects here and is not in fact the same chemical. This is s 'stop gap' to avoid misinformation. A better reference is needed as is mention of homocystinuria. Homocystine probably is not important enough to warrant it's own page. Leopardtail ( talk) 18:35, 27 May 2014 (UTC)
I noticed there was a request for documentation or citation on normal homocystine levels.
I couldn't find anything from the Framingham study that discussed this straight out, despite being implied.
But the numbers seem correct.
I think this might be a valuable link http://www.emedicinehealth.com/homocysteine/page4_em.htm
If so you can add the citation and adjust the test.
Hope this helps — Preceding unsigned comment added by Cdmphy ( talk • contribs) 22:46, 7 April 2016 (UTC)
The comment(s) below were originally left at Talk:Homocysteine/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
The Table containing limits of Homocysteine has two different values for Female>60 years. The recommended values for Males >60years is missing. Obviously there is a simple error. The author may be contacted to correct the error.
|
Last edited at 17:42, 26 November 2008 (UTC). Substituted at 18:12, 29 April 2016 (UTC)
HomocystIne redicts to this page, and one part refers to HomocystIne as if it were an alternative spelling.
HomocystIne is however a compound formed of two HomocystEIne molecules with a disuplhide bond. This page either needs section covering Homocystine (not ideal) or the page for that molecule needs to be restored. -- Leopardtail ( talk) 13:48, 21 May 2017 (UTC)
Hello fellow Wikipedians,
I have just modified one external link on Homocysteine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 07:57, 6 November 2017 (UTC)
Why does the atherogenesis link near the top bring up atherosclerosis in the mouse over? 4.36.46.138 ( talk) 17:01, 9 July 2024 (UTC)