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Wnt does act as a guidance cue, not sure about Shh. Probably though - most things that set up gradients determining cell fates also act as guidance cues. Specifically wnt guides Retinal Ganglion Cell axons pathfinding to the optic tectum. CWB —Preceding unsigned comment added by 188.223.85.80 ( talk) 21:01, 31 July 2010 (UTC)
I noticed something bizzare, there is a line in the page that reads " It has more recently been shown that cell fate determinants such as wnt and sonic hedgehog(shh) can also act as guidance cues."
I don't think that is correct, can someone who is more experience on this topic than I, please fix it
Hi, I'm going to be editing this page. I plan to just expand all the categories and supply more detailed information in each one. I also plan on adding another category about axon and branch growth in addition to the category on axon guidance. The images that I will be adding are my own, and I am willing to make any changes to the images if anyone has suggestions. I will make these changes soon, and they will probably be made in just one or two additions. Chris1387 ( talk) 19:04, 4 April 2008 (UTC)
I think it is true that shh at least can act as a repulsive cue in the optic chiasm. I'm not perfectly sure how this works, but isn't the target of Shh-Signaling (Ci/Gli) bound to microtubili by factors that are phosphorylated during Shh-Signaling? I hope someone knows better than me... Clbl134 —Preceding unsigned comment added by 132.230.21.52 ( talk) 16:50, 16 April 2008 (UTC)
Someone with the knowledge of the subject might add a proper clause telling that this protein inhibits axonal growth. -- CopperKettle 15:33, 12 January 2009 (UTC)
This image is needlessly confusing, since it reverse the colour coding for actin and microtubules that's followed in the first image. (The colouring in the second image is not clear). The usual textbook standard is actin in red and MTs in green. 67.230.143.151 ( talk) 14:57, 23 April 2013 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||
|
Wnt does act as a guidance cue, not sure about Shh. Probably though - most things that set up gradients determining cell fates also act as guidance cues. Specifically wnt guides Retinal Ganglion Cell axons pathfinding to the optic tectum. CWB —Preceding unsigned comment added by 188.223.85.80 ( talk) 21:01, 31 July 2010 (UTC)
I noticed something bizzare, there is a line in the page that reads " It has more recently been shown that cell fate determinants such as wnt and sonic hedgehog(shh) can also act as guidance cues."
I don't think that is correct, can someone who is more experience on this topic than I, please fix it
Hi, I'm going to be editing this page. I plan to just expand all the categories and supply more detailed information in each one. I also plan on adding another category about axon and branch growth in addition to the category on axon guidance. The images that I will be adding are my own, and I am willing to make any changes to the images if anyone has suggestions. I will make these changes soon, and they will probably be made in just one or two additions. Chris1387 ( talk) 19:04, 4 April 2008 (UTC)
I think it is true that shh at least can act as a repulsive cue in the optic chiasm. I'm not perfectly sure how this works, but isn't the target of Shh-Signaling (Ci/Gli) bound to microtubili by factors that are phosphorylated during Shh-Signaling? I hope someone knows better than me... Clbl134 —Preceding unsigned comment added by 132.230.21.52 ( talk) 16:50, 16 April 2008 (UTC)
Someone with the knowledge of the subject might add a proper clause telling that this protein inhibits axonal growth. -- CopperKettle 15:33, 12 January 2009 (UTC)
This image is needlessly confusing, since it reverse the colour coding for actin and microtubules that's followed in the first image. (The colouring in the second image is not clear). The usual textbook standard is actin in red and MTs in green. 67.230.143.151 ( talk) 14:57, 23 April 2013 (UTC)