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![]() | Gene expression received a peer review by Wikipedia editors, which is now archived. It may contain ideas you can use to improve this article. |
A summary of this article appears in gene. |
![]() | This article was the
MCB Collaboration of the Month for the month of April 2009-February 2010. For more details, see the
MCB Collaboration of the Month history. |
Southgatea ( talk) 21:28, 25 February 2020 (UTC) edits to the article to make it more general. more as an entry page to more generalized articles. in that spirit added link to other pages. Also introduce the connections to the central dogma.
Need slow throughput techniques e.g. northern blot -- Zven 12:12, 17 September 2006 (UTC)
I just updated this entire section, adding, for example, the northern blot, and a little more information on DNA microarrays. I also cleaned up the language to make it hopefully more accurate. I also updated the protein-level measurement part, since the original author was apparently unaware that Western blots are still the standard method of choice for reporting protein levels. Let me know what you think. -- Josh 03:36, 7 June 2007 (UTC)
Consider the totality of all gene expressions within a chromosome. Are all genes on the same side of the DNA strand? In other words if you split the double helix are all the genes on one strand or are they staggered between the two strands?
Backing that up, open reading frames can occur on either strand in either direction Silasmellor ( talk) 14:22, 10 May 2009 (UTC)
moved terms to Glossary of Scientific Terms related to Gene Expression. Removed empty section.
Why does housekeeping genes redirect to this article? ώЇЌĩ Ѕαи Яоzε †αLҝ 21:50, 11 June 2007 (UTC)
Was:
But:
So is now:
Jethero Talk 00:49, 9 July 2007 (UTC)
I removed the initial lines "The expression of many genes is regulated after transcription (i.e., by microRNAs or ubiquitin ligases), so an increase in mRNA concentration need not always increase expression. In fact, mRNA concentration has been shown to be a poor predictor of resultant protein abundance.[1][2]" because IMHO it serves as a pretty bad start for what essentially should just be a walk-through of the different methods that exists to quantify mRNA (ie. the de facto definition of gene expression in the litterature). Even if we do want to talk proteins, and I agree that this is relevant, it should come in another section. -- LasseFolkersen ( talk) 12:50, 31 March 2009 (UTC)
This article is the MCB Wikiprojects Collaboration of the Month. What does it need? It appears to me that each of the sections should have a "main article: bla" link in it, for starters. Then we need to decide how much detail goes into those sections, as each step (i.e. Transcription, Translation, etc.) has its own article already. Should we be trying to improve the overall understanding of the whole process of expression here? It's not entirely clear to me what the goal of the article is. Agathman ( talk) 00:11, 28 May 2009 (UTC)
This article currently has a significant eukaryoitic bias; please try to avoid this! I will make some edits to clarify the differences between prokaryotic and eukaryotic gene expression, particularly with respect to co-translation in prok's, RNA processing, nuclear export, folding location and secretion via exocytic pathways. - Zephyris Talk 10:33, 29 July 2009 (UTC)
The protein expression article seems abandoned. Should it be deleted and redirected to gene expression? Pdcook ( talk) 19:38, 11 September 2009 (UTC)
It would be nice if we could make a decision on this soon. Pdcook ( talk) 03:22, 27 September 2009 (UTC)
The previous version of this text explained correctly, that the produced RNA strand is complimentary to the used template DNA strand. DNA "TAC" to RNA "AUG" (encoding for methionine and also serving as start codon for translation) was given as an example. However, the template DNA strand is itself read in "reverse" 3' → 5' direction to create the new strand in 5' → 3' "sense" direction. The newly generated 5' → 3' RNA is therefore identical to the 5' → 3' coding strand of the DNA (complimentary strand of a complimentary strand), with the difference that T is replaced by U in RNA, of course. This new version is in concordance with the more detailed Transcription (genetics) article and, I believe, less confusing to the first time reader. -- Firefly's luciferase ( talk) 03:01, 26 February 2010 (UTC)
The words inducible gene redirect here and yet there's absolutely no trace of the word "inducible" in this article. Someone fix this please or remove the redirect and create a separate article for what an inducible gene is. 98.176.12.43 ( talk) 19:34, 9 October 2010 (UTC)
Regulation of gene expression#Methods has a more extensive section on tools, albeit it has a focus on whether the abundance measured is relative or absolute (e.i. protein foo @ condition B is n times higher than @ condition A or foo is n pM ), as the article is about change in expression levels. Maybe a copy-paste possibility? -- Squidonius ( talk) 03:21, 10 October 2010 (UTC)
Overexpression redirects to this article. What does it mean? -- Abdull ( talk) 12:29, 2 June 2012 (UTC)
Both the articles refer to the same thing. I see no dissimilarities. The ultimate goal of gene expression is protein synthesis. These two articles are like seeing a snake from its mouth and from the tail. So I propose to merge the two articles. This message will also be posted on Gene expression article. -- G.Kiruthikan ( talk) 13:58, 1 March 2014 (UTC)
Overexpress and Overexpression redirect to this article but are not defined. Should the article cover the term or should redirects be removed? pgr94 ( talk) 10:41, 12 May 2014 (UTC)
The comment(s) below were originally left at Talk:Gene expression/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
high school/SAT biology topic; important overview of central MCB topic (most molecular biology research revolves around gene expression in one way or another); changed rating from high to top - tameeria 15:23, 18 February 2007 (UTC) |
Last edited at 15:23, 18 February 2007 (UTC). Substituted at 15:53, 29 April 2016 (UTC)
Long sections on "Transcriptional regulation in cancer" are being added to different articles on genetics. Whether these are WP:UNDUE is a matter of opinion, but that they are similar is not in doubt. It would make more sense to create a single article on that topic, and to link to it with a brief summary in each of the other articles. Chiswick Chap ( talk) 07:22, 30 October 2016 (UTC)
Please refer to the following line from the section 3: Measurement
".....ability to quantify the level at which a....."
Can we write "degree" instead of "level"? It sounds more expressive to me. I am not an expert, just a suggestion
''Prabhakar Sarma Neog'' ( talk) 13:42, 1 August 2017 (UTC)
Not sure if this is the way to ask questions. Apologies otherwise.
In the section on mechanism there is the following statement:
"The ribosome helps transfer RNA to bind to messenger RNA and takes the amino acid from each transfer RNA and makes a structure-less protein out of it.[9][10] Each mRNA molecule is translated into many protein molecules, on average ~2800 in mammals."
My question: Are these 2800 DIFFERENT proteins of 2800 COPIES of a protein molecule? can someone clarify. Thanks — Preceding unsigned comment added by 24.251.100.217 ( talk) 00:47, 6 January 2019 (UTC)
An editor has identified a potential problem with the redirect
Over expression and has thus listed it
for discussion. This discussion will occur at
Wikipedia:Redirects for discussion/Log/2022 February 5#Over expression until a consensus is reached, and readers of this page are welcome to contribute to the discussion.
Steel1943 (
talk)
20:58, 5 February 2022 (UTC)
I propose that we remove this article and replace it with a stub containing links to gene, transcription, regulation of gene expression, translation, etc.
This is another example of redundant information that conflicts with the main articles on the subject. There's no point in having so many articles that cover the same topics - it encourages people to make edits that don't agree with information found elsewhere. Genome42 ( talk) 18:32, 2 February 2024 (UTC)
![]() | This ![]() It is of interest to the following WikiProjects: | ||||||||||||||||
|
![]() | Gene expression received a peer review by Wikipedia editors, which is now archived. It may contain ideas you can use to improve this article. |
A summary of this article appears in gene. |
![]() | This article was the
MCB Collaboration of the Month for the month of April 2009-February 2010. For more details, see the
MCB Collaboration of the Month history. |
Southgatea ( talk) 21:28, 25 February 2020 (UTC) edits to the article to make it more general. more as an entry page to more generalized articles. in that spirit added link to other pages. Also introduce the connections to the central dogma.
Need slow throughput techniques e.g. northern blot -- Zven 12:12, 17 September 2006 (UTC)
I just updated this entire section, adding, for example, the northern blot, and a little more information on DNA microarrays. I also cleaned up the language to make it hopefully more accurate. I also updated the protein-level measurement part, since the original author was apparently unaware that Western blots are still the standard method of choice for reporting protein levels. Let me know what you think. -- Josh 03:36, 7 June 2007 (UTC)
Consider the totality of all gene expressions within a chromosome. Are all genes on the same side of the DNA strand? In other words if you split the double helix are all the genes on one strand or are they staggered between the two strands?
Backing that up, open reading frames can occur on either strand in either direction Silasmellor ( talk) 14:22, 10 May 2009 (UTC)
moved terms to Glossary of Scientific Terms related to Gene Expression. Removed empty section.
Why does housekeeping genes redirect to this article? ώЇЌĩ Ѕαи Яоzε †αLҝ 21:50, 11 June 2007 (UTC)
Was:
But:
So is now:
Jethero Talk 00:49, 9 July 2007 (UTC)
I removed the initial lines "The expression of many genes is regulated after transcription (i.e., by microRNAs or ubiquitin ligases), so an increase in mRNA concentration need not always increase expression. In fact, mRNA concentration has been shown to be a poor predictor of resultant protein abundance.[1][2]" because IMHO it serves as a pretty bad start for what essentially should just be a walk-through of the different methods that exists to quantify mRNA (ie. the de facto definition of gene expression in the litterature). Even if we do want to talk proteins, and I agree that this is relevant, it should come in another section. -- LasseFolkersen ( talk) 12:50, 31 March 2009 (UTC)
This article is the MCB Wikiprojects Collaboration of the Month. What does it need? It appears to me that each of the sections should have a "main article: bla" link in it, for starters. Then we need to decide how much detail goes into those sections, as each step (i.e. Transcription, Translation, etc.) has its own article already. Should we be trying to improve the overall understanding of the whole process of expression here? It's not entirely clear to me what the goal of the article is. Agathman ( talk) 00:11, 28 May 2009 (UTC)
This article currently has a significant eukaryoitic bias; please try to avoid this! I will make some edits to clarify the differences between prokaryotic and eukaryotic gene expression, particularly with respect to co-translation in prok's, RNA processing, nuclear export, folding location and secretion via exocytic pathways. - Zephyris Talk 10:33, 29 July 2009 (UTC)
The protein expression article seems abandoned. Should it be deleted and redirected to gene expression? Pdcook ( talk) 19:38, 11 September 2009 (UTC)
It would be nice if we could make a decision on this soon. Pdcook ( talk) 03:22, 27 September 2009 (UTC)
The previous version of this text explained correctly, that the produced RNA strand is complimentary to the used template DNA strand. DNA "TAC" to RNA "AUG" (encoding for methionine and also serving as start codon for translation) was given as an example. However, the template DNA strand is itself read in "reverse" 3' → 5' direction to create the new strand in 5' → 3' "sense" direction. The newly generated 5' → 3' RNA is therefore identical to the 5' → 3' coding strand of the DNA (complimentary strand of a complimentary strand), with the difference that T is replaced by U in RNA, of course. This new version is in concordance with the more detailed Transcription (genetics) article and, I believe, less confusing to the first time reader. -- Firefly's luciferase ( talk) 03:01, 26 February 2010 (UTC)
The words inducible gene redirect here and yet there's absolutely no trace of the word "inducible" in this article. Someone fix this please or remove the redirect and create a separate article for what an inducible gene is. 98.176.12.43 ( talk) 19:34, 9 October 2010 (UTC)
Regulation of gene expression#Methods has a more extensive section on tools, albeit it has a focus on whether the abundance measured is relative or absolute (e.i. protein foo @ condition B is n times higher than @ condition A or foo is n pM ), as the article is about change in expression levels. Maybe a copy-paste possibility? -- Squidonius ( talk) 03:21, 10 October 2010 (UTC)
Overexpression redirects to this article. What does it mean? -- Abdull ( talk) 12:29, 2 June 2012 (UTC)
Both the articles refer to the same thing. I see no dissimilarities. The ultimate goal of gene expression is protein synthesis. These two articles are like seeing a snake from its mouth and from the tail. So I propose to merge the two articles. This message will also be posted on Gene expression article. -- G.Kiruthikan ( talk) 13:58, 1 March 2014 (UTC)
Overexpress and Overexpression redirect to this article but are not defined. Should the article cover the term or should redirects be removed? pgr94 ( talk) 10:41, 12 May 2014 (UTC)
The comment(s) below were originally left at Talk:Gene expression/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
high school/SAT biology topic; important overview of central MCB topic (most molecular biology research revolves around gene expression in one way or another); changed rating from high to top - tameeria 15:23, 18 February 2007 (UTC) |
Last edited at 15:23, 18 February 2007 (UTC). Substituted at 15:53, 29 April 2016 (UTC)
Long sections on "Transcriptional regulation in cancer" are being added to different articles on genetics. Whether these are WP:UNDUE is a matter of opinion, but that they are similar is not in doubt. It would make more sense to create a single article on that topic, and to link to it with a brief summary in each of the other articles. Chiswick Chap ( talk) 07:22, 30 October 2016 (UTC)
Please refer to the following line from the section 3: Measurement
".....ability to quantify the level at which a....."
Can we write "degree" instead of "level"? It sounds more expressive to me. I am not an expert, just a suggestion
''Prabhakar Sarma Neog'' ( talk) 13:42, 1 August 2017 (UTC)
Not sure if this is the way to ask questions. Apologies otherwise.
In the section on mechanism there is the following statement:
"The ribosome helps transfer RNA to bind to messenger RNA and takes the amino acid from each transfer RNA and makes a structure-less protein out of it.[9][10] Each mRNA molecule is translated into many protein molecules, on average ~2800 in mammals."
My question: Are these 2800 DIFFERENT proteins of 2800 COPIES of a protein molecule? can someone clarify. Thanks — Preceding unsigned comment added by 24.251.100.217 ( talk) 00:47, 6 January 2019 (UTC)
An editor has identified a potential problem with the redirect
Over expression and has thus listed it
for discussion. This discussion will occur at
Wikipedia:Redirects for discussion/Log/2022 February 5#Over expression until a consensus is reached, and readers of this page are welcome to contribute to the discussion.
Steel1943 (
talk)
20:58, 5 February 2022 (UTC)
I propose that we remove this article and replace it with a stub containing links to gene, transcription, regulation of gene expression, translation, etc.
This is another example of redundant information that conflicts with the main articles on the subject. There's no point in having so many articles that cover the same topics - it encourages people to make edits that don't agree with information found elsewhere. Genome42 ( talk) 18:32, 2 February 2024 (UTC)