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Page moved to Talk:Vitamin B12. But there may be some cyanocobalamin-specific related issues still to treat here, so I've left it as a TALK page, not a simple redirect.
S B H arris 06:52, 3 December 2007 (UTC)
I have no objection to it being a dab/direct in B12 pages, but putting it in here in cyanocobalamin, is just too much. I'm taking it out. S B H arris 04:06, 4 December 2007 (UTC)
I've moved this section here until it can be verified and referenced:
-- Ed ( Edgar181) 12:33, 7 January 2008 (UTC)
This article might shed some light. (I'll read it when I have more time):
PMID
7090966. --
Rifleman 82 (
talk)
14:20, 7 January 2008 (UTC)
It is safe to pitch this into the dust bin. Potassium cyanide is NOT a concern. In fact, potassium cyanide isn't the concern at all, and those who observed that the potassium moiety is irrelevant are quite correct. KCN
salt doesn't exist in the body: KCN is only present in solution, and it is fully ionized. Ditto for NaCN, LiCN, etc. HCN is a
weak acid so it remains in equilibrium and a problem--the cell membrane is permeable to HCN.
There is no such thing a potassium reacting with cyanide. The moment KCN is dissolved becomes K+ and CN-. It is the CN- that is toxic. Unless someone has nabbed your liver & kidneys, the human body is quite capable of converting excess cyanide into thiocyanate and other such compounds. Happens every day. The trivial amounts of CN in cyanocobalamin used as a vitamin B12 source are not concerning.
There is one case where the CN-cobalamin v. OH-cobalmin makes a difference: treatment of
cyanide poisoning. Large doses (much, much larger than is needed for vitamin use) of OH-cobalamin can be used to treat CN poisoning, as it combines with CN-. The body then can eliminate the excess cyanide via the usual
Rhodanese pathway.
24.91.99.19 ( talk) 22:25, 24 January 2010 (UTC)KC, MD
I suggest to completely rewrite the Criticisms of Cyanocobalamin as a B12 supplement section along the lines of the following article: [2]
-- Compostus ( talk) 09:07, 29 August 2015 (UTC)
"This fact has caused some people (usually from reading labels on packages and vitamin supplements, in which vitamin B-12 is almost always listed last, since ingredients by law are listed in order of weight percentage)"
I know that US law mandates that food list ingredients in order of weight, do other countries have this law? —Preceding unsigned comment added by 96.251.28.105 ( talk) 13:01, 13 February 2009 (UTC)
Animal Protein Factor redirects here but there's no explaination or mention of Animal Protein Factor in this article Nil Einne ( talk) 09:52, 2 November 2010 (UTC)
exasperating.
Shjacks45 ( talk) 07:56, 11 September 2011 (UTC)
I think I'm missing something. At present the into of the article states "Vitamin B12 is the name for a whole class of precursors to vitamin B12", and my brain is now stuck in an infinite loop. I expect that this statement is based on something accurate, but at present it seems to be a confusing, non-helpful way to say it. I hope someone with more knowledge that me can clarify. -- Keithonearth ( talk) 19:50, 3 March 2012 (UTC)
The molecular structure is mad in another program than the structure for Methylcobalamin and Hydroxocobalamin, which makes the hard to compare. I know it's only a question of the part that binds Co, but it would still be easier to conclude the rest of the structure is the same, if it was drawn in the same fashion. Can anyone do it in an easy way?
OxygenBlue ( talk) 07:10, 24 July 2012 (UTC)
Should there be a reference on this page to the enzyme Cyanocobalamin reductase? Looking this up on google, I ran across the enzyme article. (Safari auto-spell-guess-auto-search is nice..) I don't know enough about it (obviously) to know where (or if) it is a major contributor to Cyano-B12 metabolism in humans or bacteria. — Preceding unsigned comment added by Jimw338 ( talk • contribs) 19:16, 6 September 2012 (UTC)
I come across this on several medical/drug info sites, take for example the Drug label from American Regent, Inc. on nih.gov:
However, apart from Warning sections, I haven't found any mention of aluminum. It's not listed under the active or inactive ingredients.
So where does it come from, some impurity from the production process? And in what form is it? Ssscienccce ( talk) 08:34, 20 November 2012 (UTC)
so I'll rename it to Vitamin B12 metabolism, and most of it should move to the Vitamin B12 article. - Rod57 ( talk) 13:58, 17 August 2015 (UTC)
The "Criticisms of Cyanocobalamin as a B12 supplement" section of this article is very poorly written, repetitive, and lacking of sources. I suggest a major cleanup or deletion of that section. PStrait ( talk) 03:05, 9 January 2016 (UTC)
I deleted the entire section. As a person with a doctorate in nutritional biochemistry from MIT, I agree with the opinion above. The content lacked references, and those provided did not support the content. Cyanocobalamin is widely accepted as a synthetic, supplement-appropriate form of vitamin B12 - functional and safe. David notMD ( talk) 02:49, 28 February 2016 (UTC)
I have been attempting to clean up style and remove text either redundant or contentious. Next step to consider is severely cutting the entire B12 metabolism section, as this is covered in the vitamin B12 entry. THIS entry on cyanocobalamin should be on that synthetic compound and not on what happens after it is converted to the physiologically active compounds. David notMD ( talk) 12:57, 1 March 2016 (UTC)
At the end of the 'Production' subsection, we have this line:
"The total world production of vitamin B12, by four companies (the French Sanofi-Aventis and three Chinese companies) in 2008 was 35 tonnes."
Is there a reason why only the French company is mentioned and not the three Chinese companies? I think all four companies should be mentioned, else the whole of the brackets should be removed. The cited article is paywalled, so I'm unsure if the original source mentions all four companies. WikidKev ( talk) 23:06, 10 January 2024 (UTC)
The cheapest sources of cyanocobalamin come from human sewage treatment plants where they take the sludge & turn it into a powder for energy drink companies. 2600:1700:9461:2020:6961:F9A0:93BF:28AD ( talk) 16:08, 14 April 2024 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||||||
|
Page moved to Talk:Vitamin B12. But there may be some cyanocobalamin-specific related issues still to treat here, so I've left it as a TALK page, not a simple redirect.
S B H arris 06:52, 3 December 2007 (UTC)
I have no objection to it being a dab/direct in B12 pages, but putting it in here in cyanocobalamin, is just too much. I'm taking it out. S B H arris 04:06, 4 December 2007 (UTC)
I've moved this section here until it can be verified and referenced:
-- Ed ( Edgar181) 12:33, 7 January 2008 (UTC)
This article might shed some light. (I'll read it when I have more time):
PMID
7090966. --
Rifleman 82 (
talk)
14:20, 7 January 2008 (UTC)
It is safe to pitch this into the dust bin. Potassium cyanide is NOT a concern. In fact, potassium cyanide isn't the concern at all, and those who observed that the potassium moiety is irrelevant are quite correct. KCN
salt doesn't exist in the body: KCN is only present in solution, and it is fully ionized. Ditto for NaCN, LiCN, etc. HCN is a
weak acid so it remains in equilibrium and a problem--the cell membrane is permeable to HCN.
There is no such thing a potassium reacting with cyanide. The moment KCN is dissolved becomes K+ and CN-. It is the CN- that is toxic. Unless someone has nabbed your liver & kidneys, the human body is quite capable of converting excess cyanide into thiocyanate and other such compounds. Happens every day. The trivial amounts of CN in cyanocobalamin used as a vitamin B12 source are not concerning.
There is one case where the CN-cobalamin v. OH-cobalmin makes a difference: treatment of
cyanide poisoning. Large doses (much, much larger than is needed for vitamin use) of OH-cobalamin can be used to treat CN poisoning, as it combines with CN-. The body then can eliminate the excess cyanide via the usual
Rhodanese pathway.
24.91.99.19 ( talk) 22:25, 24 January 2010 (UTC)KC, MD
I suggest to completely rewrite the Criticisms of Cyanocobalamin as a B12 supplement section along the lines of the following article: [2]
-- Compostus ( talk) 09:07, 29 August 2015 (UTC)
"This fact has caused some people (usually from reading labels on packages and vitamin supplements, in which vitamin B-12 is almost always listed last, since ingredients by law are listed in order of weight percentage)"
I know that US law mandates that food list ingredients in order of weight, do other countries have this law? —Preceding unsigned comment added by 96.251.28.105 ( talk) 13:01, 13 February 2009 (UTC)
Animal Protein Factor redirects here but there's no explaination or mention of Animal Protein Factor in this article Nil Einne ( talk) 09:52, 2 November 2010 (UTC)
exasperating.
Shjacks45 ( talk) 07:56, 11 September 2011 (UTC)
I think I'm missing something. At present the into of the article states "Vitamin B12 is the name for a whole class of precursors to vitamin B12", and my brain is now stuck in an infinite loop. I expect that this statement is based on something accurate, but at present it seems to be a confusing, non-helpful way to say it. I hope someone with more knowledge that me can clarify. -- Keithonearth ( talk) 19:50, 3 March 2012 (UTC)
The molecular structure is mad in another program than the structure for Methylcobalamin and Hydroxocobalamin, which makes the hard to compare. I know it's only a question of the part that binds Co, but it would still be easier to conclude the rest of the structure is the same, if it was drawn in the same fashion. Can anyone do it in an easy way?
OxygenBlue ( talk) 07:10, 24 July 2012 (UTC)
Should there be a reference on this page to the enzyme Cyanocobalamin reductase? Looking this up on google, I ran across the enzyme article. (Safari auto-spell-guess-auto-search is nice..) I don't know enough about it (obviously) to know where (or if) it is a major contributor to Cyano-B12 metabolism in humans or bacteria. — Preceding unsigned comment added by Jimw338 ( talk • contribs) 19:16, 6 September 2012 (UTC)
I come across this on several medical/drug info sites, take for example the Drug label from American Regent, Inc. on nih.gov:
However, apart from Warning sections, I haven't found any mention of aluminum. It's not listed under the active or inactive ingredients.
So where does it come from, some impurity from the production process? And in what form is it? Ssscienccce ( talk) 08:34, 20 November 2012 (UTC)
so I'll rename it to Vitamin B12 metabolism, and most of it should move to the Vitamin B12 article. - Rod57 ( talk) 13:58, 17 August 2015 (UTC)
The "Criticisms of Cyanocobalamin as a B12 supplement" section of this article is very poorly written, repetitive, and lacking of sources. I suggest a major cleanup or deletion of that section. PStrait ( talk) 03:05, 9 January 2016 (UTC)
I deleted the entire section. As a person with a doctorate in nutritional biochemistry from MIT, I agree with the opinion above. The content lacked references, and those provided did not support the content. Cyanocobalamin is widely accepted as a synthetic, supplement-appropriate form of vitamin B12 - functional and safe. David notMD ( talk) 02:49, 28 February 2016 (UTC)
I have been attempting to clean up style and remove text either redundant or contentious. Next step to consider is severely cutting the entire B12 metabolism section, as this is covered in the vitamin B12 entry. THIS entry on cyanocobalamin should be on that synthetic compound and not on what happens after it is converted to the physiologically active compounds. David notMD ( talk) 12:57, 1 March 2016 (UTC)
At the end of the 'Production' subsection, we have this line:
"The total world production of vitamin B12, by four companies (the French Sanofi-Aventis and three Chinese companies) in 2008 was 35 tonnes."
Is there a reason why only the French company is mentioned and not the three Chinese companies? I think all four companies should be mentioned, else the whole of the brackets should be removed. The cited article is paywalled, so I'm unsure if the original source mentions all four companies. WikidKev ( talk) 23:06, 10 January 2024 (UTC)
The cheapest sources of cyanocobalamin come from human sewage treatment plants where they take the sludge & turn it into a powder for energy drink companies. 2600:1700:9461:2020:6961:F9A0:93BF:28AD ( talk) 16:08, 14 April 2024 (UTC)