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Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available
on the course page. Student editor(s):
HelinaSaleh. Peer reviewers:
Untediousness.
I am planning to make some changes and update the info on the Chemogenetics Page and I would kindly appreciate your feed back . I have written the preliminary outline below. Thank you .
Chemogenetics
Indicate the difference between optogenetics and chemogenetics ( i.e., Having more spatiotemporal control . ) Explain how the spatiotemporal control is achieved .
Explain more about the process of designing DREADDs and retro DREADDS.
Benefits :
Pharmacology and treating different diseases : link the information to the diseases page . The targeted diseases in chemogenetics currently consist of neurodegenerative disorders such as Parkinsons disease and neuropsychological disorders such as addiction and anxiety, depression and Schizophrenia.
The advancement of chemogenetics in pain management . ( add osteoarthritis associated pain to the diseases under investigation in this field. )
Animal Models :
Advancement and limits : explain non primate models used such as rodent models. Discuss the advancement s and limitation of using non human primate models.
Future Direction :
discuss the future directions considered in the literature and how chemogenetics can be incorporated to treat different disorders. HelinaSaleh (talk) 21:24, 11 May 2017 (UTC)
References so far include :
Galvan, Adriana; Caiola, Michael J.; Albaugh, Daniel L. (2017-02-25). "Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates". Journal of Neural Transmission: 1–17. doi:10.1007/s00702-017-1697-8. ISSN 0300-9564.
Dobrzanski, Grzegorz; Kossut, Małgorzata (2017-04-01). "Application of the DREADD technique in biomedical brain research". Pharmacological Reports. 69 (2): 213–221. doi:10.1016/j.pharep.2016.10.015.
Bang, Juwon; Kim, Hak Yeong; Lee, Hyosang. "Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters". Experimental Neurobiology. 25 (5). doi:10.5607/en.2016.25.5.205. PMC 5081467 Freely accessible.
PMID27790055.
Miller, Rachel E.; Ishihara, Shingo; Bhattacharyya, Bula; Delaney, Ada; Menichella, Daniela M.; Miller, Richard J.; Malfait, Anne-Marie (2017-04-01). "Chemogenetic inhibition of pain neurons in a mouse model of osteoarthritis". Arthritis & Rheumatology: n/a–n/a. doi:10.1002/art.40118. ISSN 2326-5205.
I recommend starting the article with a clear description of the method. Currently it jumps straight into a comparison with optogenetics and applications, both of which will be easier to read with a bit more description of the method.
T.Shafee(Evo&Evo)talk 10:55, 31 May 2018 (UTC)reply
In particular, the first sentence (lead sentence) needs to be as clear and succinct as possible. I recommend checking how it is introduced in the published literature.
T.Shafee(Evo&Evo)talk 11:02, 31 May 2018 (UTC)reply
This article is within the scope of WikiProject Neuroscience, a collaborative effort to improve the coverage of
Neuroscience on Wikipedia. If you would like to participate, please visit the project page, where you can join
the discussion and see a list of open tasks.NeuroscienceWikipedia:WikiProject NeuroscienceTemplate:WikiProject Neuroscienceneuroscience articles
This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of
Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join
the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
This article is within the scope of WikiProject Psychology, a collaborative effort to improve the coverage of
Psychology on Wikipedia. If you would like to participate, please visit the project page, where you can join
the discussion and see a list of open tasks.PsychologyWikipedia:WikiProject PsychologyTemplate:WikiProject Psychologypsychology articles
Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available
on the course page. Student editor(s):
HelinaSaleh. Peer reviewers:
Untediousness.
I am planning to make some changes and update the info on the Chemogenetics Page and I would kindly appreciate your feed back . I have written the preliminary outline below. Thank you .
Chemogenetics
Indicate the difference between optogenetics and chemogenetics ( i.e., Having more spatiotemporal control . ) Explain how the spatiotemporal control is achieved .
Explain more about the process of designing DREADDs and retro DREADDS.
Benefits :
Pharmacology and treating different diseases : link the information to the diseases page . The targeted diseases in chemogenetics currently consist of neurodegenerative disorders such as Parkinsons disease and neuropsychological disorders such as addiction and anxiety, depression and Schizophrenia.
The advancement of chemogenetics in pain management . ( add osteoarthritis associated pain to the diseases under investigation in this field. )
Animal Models :
Advancement and limits : explain non primate models used such as rodent models. Discuss the advancement s and limitation of using non human primate models.
Future Direction :
discuss the future directions considered in the literature and how chemogenetics can be incorporated to treat different disorders. HelinaSaleh (talk) 21:24, 11 May 2017 (UTC)
References so far include :
Galvan, Adriana; Caiola, Michael J.; Albaugh, Daniel L. (2017-02-25). "Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates". Journal of Neural Transmission: 1–17. doi:10.1007/s00702-017-1697-8. ISSN 0300-9564.
Dobrzanski, Grzegorz; Kossut, Małgorzata (2017-04-01). "Application of the DREADD technique in biomedical brain research". Pharmacological Reports. 69 (2): 213–221. doi:10.1016/j.pharep.2016.10.015.
Bang, Juwon; Kim, Hak Yeong; Lee, Hyosang. "Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters". Experimental Neurobiology. 25 (5). doi:10.5607/en.2016.25.5.205. PMC 5081467 Freely accessible.
PMID27790055.
Miller, Rachel E.; Ishihara, Shingo; Bhattacharyya, Bula; Delaney, Ada; Menichella, Daniela M.; Miller, Richard J.; Malfait, Anne-Marie (2017-04-01). "Chemogenetic inhibition of pain neurons in a mouse model of osteoarthritis". Arthritis & Rheumatology: n/a–n/a. doi:10.1002/art.40118. ISSN 2326-5205.
I recommend starting the article with a clear description of the method. Currently it jumps straight into a comparison with optogenetics and applications, both of which will be easier to read with a bit more description of the method.
T.Shafee(Evo&Evo)talk 10:55, 31 May 2018 (UTC)reply
In particular, the first sentence (lead sentence) needs to be as clear and succinct as possible. I recommend checking how it is introduced in the published literature.
T.Shafee(Evo&Evo)talk 11:02, 31 May 2018 (UTC)reply