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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available
on the course page. Student editor(s):
Jsa951624,
Aishamunir1. Peer reviewers:
Aishamunir1.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 17:17, 16 January 2022 (UTC)
Added chelation in plants and micro-organisms. Chemists should dig up references for the other bits. Miikka Raninen 19:38, 27 November 2005 (UTC)
I believe so, so I'm adding it. -- Rajah 01:19, 9 July 2006 (UTC)
I support the merger (hardly anything links here anyway). -- Dirk Beetstra T C 22:53, 17 July 2006 (UTC)
I also think they should be merged.
- rshigeta
I agree. The merge seems sensible. - mc043
OOps .. forgot to tell, I already merged all the articles together (chelate effect, chelation, chelant, etc). All is now 'here'. -- Dirk Beetstra T C 07:07, 16 August 2006 (UTC)
Important addition to the definition: it should emphasize that a single bond does not form a chelate -- this term is generally reserved for two or more bonds, of any type, between the chelating agent and the metal ion. Axewiki 15:05, 28 September 2006 (UTC)
Right now,it says this:
In nutrition, certain amino acids are utilized as chelating agents to replicate the natural mineral forms found in raw fruits, vegetables, and grains. The resultant chelated minerals are absorbed directly into the bloodstream through the intestinal villi in relatively high proportions. Because micromineral levels in farm soils tend to gradually decline over the years, and because modern food processing often breaks the chelate bond and renders any remaining minerals much less bioavailable, humans today receive reduced quantities of minerals from their meals[verification needed]. Dozens of medical studies have shown that dietary supplementation with both vitamins and chelated minerals can have wide-ranging benefits to health, mental acuity, and life expectancy[verification needed]. Chelated minerals are sometimes prescribed by doctors to treat such ailments as anemia, arthritis, diabetes, nervous disorders, and heart attacks[verification needed].
Fortunately it already says 'verification needed' but the whole section is less-than-factual in tone.
micromineral levels in farm soils tend to gradually decline over the years - this is what soil fertilizer is for, right? (non-nutrition sidenote: There's a serious environmental issue with overmineralization of soil, due to excess supply with dung from intensive farming. This lead to obligatory registration, for farms in Europe, of their total mineral input and output.)
modern food processing often breaks the chelate bond - I actually came to this article after reading some concerns about artificial chelate agents such as EDTA being used as additives!! Seems there's very opposing concerns.
humans today receive reduced quantities of minerals from their meals - source badly needed.
Dozens of medical studies have shown - - source badly needed. wording very non-factual
The nutritional claims should IMHO refer to the wiki article on
Dietary mineral. Whether the minerals used in mineral supplements are usually administered in the form of chelates,is relevant but needs verification.
Chelated minerals are sometimes prescribed by doctors - it is important to note that
Chelation Therapy , (linked in 'see also') , is actually about administering chelating agents to remove excess minerals, not about medical use of chelated minerals. Is there any source or article supporting these medical claims on the use of chelated minerals, other than anything being said in
Dietary mineral ?
--
83.83.58.242 09:17, 21 October 2006 (UTC)
I recall seeing a talk show on Canadian TV. It had one host, and multiple guests. The show was about anti-aging or something.
It stuck with me that one of the guests explained that hardening of the arteries ( atherosclerosis) involved a calcification process of the blood vessel walls, and that Calcium was a metal. Even back then the guest stated that it was very difficult to locate a doctor who would administer chelation therapy to reduce the calcification of a patient's circulatory system to fix heart disease or poor circulation troubles.
He explained that the chelation therapy treatment had no horrendous side-effects, since, after all, it was already being used as a safe, effective treatment method for heavy metal poisoning. It was extremely frustrating and puzzling to him how illogical the American Medical Association (AMA) treated this practice issue. Most doctors would refuse to treat atherosclerosis using chelation therapy because it was not a listed protocol for its treatment. Using a protocol not listed as standard operating procedure for a given disease is grounds for medical malpractice. As such doctors who are timid about lawsuits or worse, losing their license to practice medicine are forced to comply with the established protocols of surgery or administering drug therapy instead.
The TV guest listed several US states where some doctors could be eventually found to prescribe this treatment without it being a case of heavy metal poisoning. He explained also that even those friendly doctors did not want to use the procedure very often on the same patient. He explained that calcium was added back in order to reduce thinning of bone. He also explained that the post-treatment adding back of calcium and other vitamins and minerals done to prevent unnecessary losses of this nature, made patients "feel" great as much if not more so than had they only just been treated with the chelating agent. The patients so treated, the guest claimed remarkably, would have virtually all of their heavy plaque deposits stripped away, leaving their blood vessels / heart / valves free to operate almost as effectively as a young healthy athlete.
He or another guest were also heavily endorsing anti-oxidants. I seem to recall that it was folic acid--and that several vegetables and plants were mentioned that contained this substance.
Ketosis and ketones were also explained.
From chemistry I seem to remember that Calcium is a fairly reactive metal, and that trying to chelate it might be a tough job so that any agent used to grab it might easily grab other less reactive metals from one's system. It is not quite as reactive as sodium, but quite nasty if not found in ionic solution or in salt form.
In the TV show, to my recollection of it now, did not have any specifics about the chelating agent used for the atherosclerosis treatment. From the description of the various chelating agents listed, specifically that different agents more specifically target certain metals, then calcium as a highly reactive metal would be more troublesome to specifically chelate. If a double-blind study were used with inappropriate chelating agents being used, the conclusions would be forgone that failure would be the outcome of such an exercise: ie., chelating is no more effective than placebo--which would be inaccurate and biased. Oldspammer 18:16, 27 May 2007 (UTC)
"...Autistic individuals generally reject this treatment for being unnecessary..." Somehow this seems to beg the question, how far autistic people are able to judge and therefore determine their treatment and it being necessary or not. Should this be rephrased? Surely it should read "carers" or "people in charge of their care" (who reject this treatment)? Dieter Simon 23:06, 4 July 2007 (UTC)
I am very offended. I am on the autistic spectrum and am studying at a top 10 UK university, living without a carer etc. Autism is not Down's Syndrome or any such condition, many people may posess a mild form of Autism without you realising, such as Aspergers etc.
You are clearly ignorant of the condition in its many forms and would benefit from looking up the article regarding the condition on Wikipedia. —Preceding unsigned comment added by 86.152.230.128 ( talk) 10:07, 6 April 2010 (UTC)
I don't know IPA. Pronunciation is key-lation, not chee-lation. Cburnett 05:13, 9 July 2007 (UTC)
In the "The Chelate Effect" section, there is no definition of the chelate effect. That effect is defined and described more clearly though less technically at http://en.wikipedia.org/wiki/Ligand#Denticity . Cowboyjo ( talk) 17:10, 29 August 2009 (UTC)
The following section was removed from the text since it seems to be a collection site for semi-randomly selected ligands. The list could go on forever (which I realized when seeing hydrolyzed wool). So we need to come up with a more focused set of chelating agents or drop this idea. Not a really big deal to me.-- Smokefoot ( talk) 23:29, 29 August 2009 (UTC)
Quoting from "Responding to the Radiation Threat" :
" Since the biochemical properties of plutonium(IV) and iron(III) are similar, we modeled our sequestering agents after the chelating unit found in siderophores," Raymond says. Siderophores are small molecules secreted by bacteria to extract and solubilize iron. "This biomimetic approach enabled us to design multidentate hydroxypyridonate ligands that are unrivaled in terms of actinide-affinity, selectivity and efficiency.
The two best candidate hydroxypyridonate ligands -- nicknamed HOPO -- developed by Abergel and her colleagues are a tetradentate, which has four chelating arms, and an octadentate, which has eight chelating arms. The "arms" in this case are atoms with pairs of electrons available for covalent bonding with an actinide. "
Responding to the Radiation Threat from sciencedaily.com/releases/2012/03/120306181212.htm from ScienceDaily
Consider appending?
As I read this article, there is mention of citric acid (probably intending partly or fully ionized citrates) as a chelating agent for metal ions. I don't believe citrate fits the definition of chelation, but is one of a number of substances that form relatively stable complexes, some of them clathrate, without being chelates. In the case of partly ionized citrate, it is possible that some coordination bonds form, but usually hydrogen is displaced as an ion by the metal in the functioning of citrate in complexing.
I have also read that Hueckel's Rule is important in determining the stability of a chelate complex, i.e. the formation of one or more rings satisfying Hueckel's Rule by the substance being chelated. 69.127.3.215 ( talk) 13:49, 2 August 2012 (UTC)
I am adding {{Technical}}, because this article is much too technical for general readers to get any value from at all. The lead section, at least, should provide some basic understanding of what chelation is to a total layman, a person who has no understanding of chemistry but has heard the word and would like a somewhat better understanding of what it is than a dictionary affords—but to whom words like monodentate, polydentate and ligand might as well be Greek (and to whom "multiple bonded", the current gloss for polydentate, means no more than polydentate does).
Packing the article—again, especially the lead section—with links to other articles (which very likely will be no less technical than this one is) is a very poor substitute for using less technical jargon. The reader should be able to read the lead section without having to jump to any other articles to get a basic understanding of the subject.
A good starting point in fixing this serious defect might be to take every linked term in the lead section and replace it with a term (or a sentence) that would require no link for a below-average high school student to understand. That below-average high school student is very likely to be exactly the kind of reader who comes most often to this article, and its lead section should help, not confuse that student.
Anyone who can understand this article as it is now doesn't need this article.-- Jim10701 ( talk) 23:43, 26 December 2012 (UTC)
This article sorely misses an opener describing chelation in general terms for the average encyclopedia reader, before plunging into the essential chemistry involved.-- Wetman ( talk) 13:23, 7 March 2013 (UTC)
In the first paragraph it says "Involves two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central atom" - should this say ion rather than atom? KStar777 ( talk) 10:37, 16 June 2017 (UTC)
Re the statement " ... particular way that ions and molecules bond to metal ions". My suggestion is that chelation is not about bonding (single, double, triple and covalent ionic etc). It is about the points of attachment. For this reason, I had suggested the term bind" over "bond". EDTA is rather ionic in its bonding, cod of course involves a lot of pi-bonding (with double bond character). So the bonding theme can get rather involved. -- Smokefoot ( talk) 16:07, 26 December 2015 (UTC)
Perhaps we should mention that chelation can also be used to remove heavy metals from rivers, ... [1] KVDP ( talk) 13:42, 5 December 2016 (UTC)
On the page for bast fibre ( /info/en/?search=Bast_fibre) it mentions that chelating agents can be used for retting. I am not nearly knowledgeable enough to add any information about this but a small section on how and why this is sometimes done instead of traditional retting techniques would be a good addition. Alternatively (or, additionally) a section about chemical retting on the retting page ( /info/en/?search=Retting) would also be a good addition.
@ Smokefoot: I noticed that you removed my contributions from Friday. You are correct in that I indeed re-used material from another author. However, this is justified as the text is under CC BY 4.0; see WP:COMPLIC. The copyright note is in the linked PDF on the last page at the bottom left. Please let me know what you think and kindly revert your deletion. Minihaa ( talk) 12:31, 18 February 2024 (UTC)
Would this be suitable for manufacture of candles that burn with coloured flame? Metallic based flammable colourants are very common and well known - for example, strontium nitrate for bright red. The problem is, that these are ionic salts that wont readily dissolve in modern wax. Could chelation be a pathway for this? Would a chelated form of strontium or barium or lithium or whatever dissolve in wax but still burn with its well known colour? 2001:8003:E40F:9601:3977:2796:67DC:1304 ( talk) 23:00, 25 April 2024 (UTC)
![]() | This ![]() It is of interest to the following WikiProjects: | |||||||||||||||||||||||
|
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available
on the course page. Student editor(s):
Jsa951624,
Aishamunir1. Peer reviewers:
Aishamunir1.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 17:17, 16 January 2022 (UTC)
Added chelation in plants and micro-organisms. Chemists should dig up references for the other bits. Miikka Raninen 19:38, 27 November 2005 (UTC)
I believe so, so I'm adding it. -- Rajah 01:19, 9 July 2006 (UTC)
I support the merger (hardly anything links here anyway). -- Dirk Beetstra T C 22:53, 17 July 2006 (UTC)
I also think they should be merged.
- rshigeta
I agree. The merge seems sensible. - mc043
OOps .. forgot to tell, I already merged all the articles together (chelate effect, chelation, chelant, etc). All is now 'here'. -- Dirk Beetstra T C 07:07, 16 August 2006 (UTC)
Important addition to the definition: it should emphasize that a single bond does not form a chelate -- this term is generally reserved for two or more bonds, of any type, between the chelating agent and the metal ion. Axewiki 15:05, 28 September 2006 (UTC)
Right now,it says this:
In nutrition, certain amino acids are utilized as chelating agents to replicate the natural mineral forms found in raw fruits, vegetables, and grains. The resultant chelated minerals are absorbed directly into the bloodstream through the intestinal villi in relatively high proportions. Because micromineral levels in farm soils tend to gradually decline over the years, and because modern food processing often breaks the chelate bond and renders any remaining minerals much less bioavailable, humans today receive reduced quantities of minerals from their meals[verification needed]. Dozens of medical studies have shown that dietary supplementation with both vitamins and chelated minerals can have wide-ranging benefits to health, mental acuity, and life expectancy[verification needed]. Chelated minerals are sometimes prescribed by doctors to treat such ailments as anemia, arthritis, diabetes, nervous disorders, and heart attacks[verification needed].
Fortunately it already says 'verification needed' but the whole section is less-than-factual in tone.
micromineral levels in farm soils tend to gradually decline over the years - this is what soil fertilizer is for, right? (non-nutrition sidenote: There's a serious environmental issue with overmineralization of soil, due to excess supply with dung from intensive farming. This lead to obligatory registration, for farms in Europe, of their total mineral input and output.)
modern food processing often breaks the chelate bond - I actually came to this article after reading some concerns about artificial chelate agents such as EDTA being used as additives!! Seems there's very opposing concerns.
humans today receive reduced quantities of minerals from their meals - source badly needed.
Dozens of medical studies have shown - - source badly needed. wording very non-factual
The nutritional claims should IMHO refer to the wiki article on
Dietary mineral. Whether the minerals used in mineral supplements are usually administered in the form of chelates,is relevant but needs verification.
Chelated minerals are sometimes prescribed by doctors - it is important to note that
Chelation Therapy , (linked in 'see also') , is actually about administering chelating agents to remove excess minerals, not about medical use of chelated minerals. Is there any source or article supporting these medical claims on the use of chelated minerals, other than anything being said in
Dietary mineral ?
--
83.83.58.242 09:17, 21 October 2006 (UTC)
I recall seeing a talk show on Canadian TV. It had one host, and multiple guests. The show was about anti-aging or something.
It stuck with me that one of the guests explained that hardening of the arteries ( atherosclerosis) involved a calcification process of the blood vessel walls, and that Calcium was a metal. Even back then the guest stated that it was very difficult to locate a doctor who would administer chelation therapy to reduce the calcification of a patient's circulatory system to fix heart disease or poor circulation troubles.
He explained that the chelation therapy treatment had no horrendous side-effects, since, after all, it was already being used as a safe, effective treatment method for heavy metal poisoning. It was extremely frustrating and puzzling to him how illogical the American Medical Association (AMA) treated this practice issue. Most doctors would refuse to treat atherosclerosis using chelation therapy because it was not a listed protocol for its treatment. Using a protocol not listed as standard operating procedure for a given disease is grounds for medical malpractice. As such doctors who are timid about lawsuits or worse, losing their license to practice medicine are forced to comply with the established protocols of surgery or administering drug therapy instead.
The TV guest listed several US states where some doctors could be eventually found to prescribe this treatment without it being a case of heavy metal poisoning. He explained also that even those friendly doctors did not want to use the procedure very often on the same patient. He explained that calcium was added back in order to reduce thinning of bone. He also explained that the post-treatment adding back of calcium and other vitamins and minerals done to prevent unnecessary losses of this nature, made patients "feel" great as much if not more so than had they only just been treated with the chelating agent. The patients so treated, the guest claimed remarkably, would have virtually all of their heavy plaque deposits stripped away, leaving their blood vessels / heart / valves free to operate almost as effectively as a young healthy athlete.
He or another guest were also heavily endorsing anti-oxidants. I seem to recall that it was folic acid--and that several vegetables and plants were mentioned that contained this substance.
Ketosis and ketones were also explained.
From chemistry I seem to remember that Calcium is a fairly reactive metal, and that trying to chelate it might be a tough job so that any agent used to grab it might easily grab other less reactive metals from one's system. It is not quite as reactive as sodium, but quite nasty if not found in ionic solution or in salt form.
In the TV show, to my recollection of it now, did not have any specifics about the chelating agent used for the atherosclerosis treatment. From the description of the various chelating agents listed, specifically that different agents more specifically target certain metals, then calcium as a highly reactive metal would be more troublesome to specifically chelate. If a double-blind study were used with inappropriate chelating agents being used, the conclusions would be forgone that failure would be the outcome of such an exercise: ie., chelating is no more effective than placebo--which would be inaccurate and biased. Oldspammer 18:16, 27 May 2007 (UTC)
"...Autistic individuals generally reject this treatment for being unnecessary..." Somehow this seems to beg the question, how far autistic people are able to judge and therefore determine their treatment and it being necessary or not. Should this be rephrased? Surely it should read "carers" or "people in charge of their care" (who reject this treatment)? Dieter Simon 23:06, 4 July 2007 (UTC)
I am very offended. I am on the autistic spectrum and am studying at a top 10 UK university, living without a carer etc. Autism is not Down's Syndrome or any such condition, many people may posess a mild form of Autism without you realising, such as Aspergers etc.
You are clearly ignorant of the condition in its many forms and would benefit from looking up the article regarding the condition on Wikipedia. —Preceding unsigned comment added by 86.152.230.128 ( talk) 10:07, 6 April 2010 (UTC)
I don't know IPA. Pronunciation is key-lation, not chee-lation. Cburnett 05:13, 9 July 2007 (UTC)
In the "The Chelate Effect" section, there is no definition of the chelate effect. That effect is defined and described more clearly though less technically at http://en.wikipedia.org/wiki/Ligand#Denticity . Cowboyjo ( talk) 17:10, 29 August 2009 (UTC)
The following section was removed from the text since it seems to be a collection site for semi-randomly selected ligands. The list could go on forever (which I realized when seeing hydrolyzed wool). So we need to come up with a more focused set of chelating agents or drop this idea. Not a really big deal to me.-- Smokefoot ( talk) 23:29, 29 August 2009 (UTC)
Quoting from "Responding to the Radiation Threat" :
" Since the biochemical properties of plutonium(IV) and iron(III) are similar, we modeled our sequestering agents after the chelating unit found in siderophores," Raymond says. Siderophores are small molecules secreted by bacteria to extract and solubilize iron. "This biomimetic approach enabled us to design multidentate hydroxypyridonate ligands that are unrivaled in terms of actinide-affinity, selectivity and efficiency.
The two best candidate hydroxypyridonate ligands -- nicknamed HOPO -- developed by Abergel and her colleagues are a tetradentate, which has four chelating arms, and an octadentate, which has eight chelating arms. The "arms" in this case are atoms with pairs of electrons available for covalent bonding with an actinide. "
Responding to the Radiation Threat from sciencedaily.com/releases/2012/03/120306181212.htm from ScienceDaily
Consider appending?
As I read this article, there is mention of citric acid (probably intending partly or fully ionized citrates) as a chelating agent for metal ions. I don't believe citrate fits the definition of chelation, but is one of a number of substances that form relatively stable complexes, some of them clathrate, without being chelates. In the case of partly ionized citrate, it is possible that some coordination bonds form, but usually hydrogen is displaced as an ion by the metal in the functioning of citrate in complexing.
I have also read that Hueckel's Rule is important in determining the stability of a chelate complex, i.e. the formation of one or more rings satisfying Hueckel's Rule by the substance being chelated. 69.127.3.215 ( talk) 13:49, 2 August 2012 (UTC)
I am adding {{Technical}}, because this article is much too technical for general readers to get any value from at all. The lead section, at least, should provide some basic understanding of what chelation is to a total layman, a person who has no understanding of chemistry but has heard the word and would like a somewhat better understanding of what it is than a dictionary affords—but to whom words like monodentate, polydentate and ligand might as well be Greek (and to whom "multiple bonded", the current gloss for polydentate, means no more than polydentate does).
Packing the article—again, especially the lead section—with links to other articles (which very likely will be no less technical than this one is) is a very poor substitute for using less technical jargon. The reader should be able to read the lead section without having to jump to any other articles to get a basic understanding of the subject.
A good starting point in fixing this serious defect might be to take every linked term in the lead section and replace it with a term (or a sentence) that would require no link for a below-average high school student to understand. That below-average high school student is very likely to be exactly the kind of reader who comes most often to this article, and its lead section should help, not confuse that student.
Anyone who can understand this article as it is now doesn't need this article.-- Jim10701 ( talk) 23:43, 26 December 2012 (UTC)
This article sorely misses an opener describing chelation in general terms for the average encyclopedia reader, before plunging into the essential chemistry involved.-- Wetman ( talk) 13:23, 7 March 2013 (UTC)
In the first paragraph it says "Involves two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central atom" - should this say ion rather than atom? KStar777 ( talk) 10:37, 16 June 2017 (UTC)
Re the statement " ... particular way that ions and molecules bond to metal ions". My suggestion is that chelation is not about bonding (single, double, triple and covalent ionic etc). It is about the points of attachment. For this reason, I had suggested the term bind" over "bond". EDTA is rather ionic in its bonding, cod of course involves a lot of pi-bonding (with double bond character). So the bonding theme can get rather involved. -- Smokefoot ( talk) 16:07, 26 December 2015 (UTC)
Perhaps we should mention that chelation can also be used to remove heavy metals from rivers, ... [1] KVDP ( talk) 13:42, 5 December 2016 (UTC)
On the page for bast fibre ( /info/en/?search=Bast_fibre) it mentions that chelating agents can be used for retting. I am not nearly knowledgeable enough to add any information about this but a small section on how and why this is sometimes done instead of traditional retting techniques would be a good addition. Alternatively (or, additionally) a section about chemical retting on the retting page ( /info/en/?search=Retting) would also be a good addition.
@ Smokefoot: I noticed that you removed my contributions from Friday. You are correct in that I indeed re-used material from another author. However, this is justified as the text is under CC BY 4.0; see WP:COMPLIC. The copyright note is in the linked PDF on the last page at the bottom left. Please let me know what you think and kindly revert your deletion. Minihaa ( talk) 12:31, 18 February 2024 (UTC)
Would this be suitable for manufacture of candles that burn with coloured flame? Metallic based flammable colourants are very common and well known - for example, strontium nitrate for bright red. The problem is, that these are ionic salts that wont readily dissolve in modern wax. Could chelation be a pathway for this? Would a chelated form of strontium or barium or lithium or whatever dissolve in wax but still burn with its well known colour? 2001:8003:E40F:9601:3977:2796:67DC:1304 ( talk) 23:00, 25 April 2024 (UTC)