Aspirin-exacerbated respiratory disease was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (March 24, 2023, reviewed version). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated. |
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Paracetamol is not an NSAID, as may be understood from the wording "though paracetamol is generally considered safe" — Preceding unsigned comment added by 88.90.68.85 ( talk) 15:32, 21 September 2011 (UTC)
The pathogenesis section is extremely confusing. In particular, the way the sentence describing differential PGE modulation I found difficult to understand. — Preceding unsigned comment added by 99.98.209.88 ( talk) 14:09, 22 January 2013 (UTC)
Has anybody else encountered this condition with the additional symptom of severe acute pain around diaphragm & back (possibly associated with gallbladder/spleen) and, later, likely autoimmune haemolytic anaemia? — Preceding unsigned comment added by 95.151.241.169 ( talk) 19:52, 25 September 2013 (UTC)
Also, interested in finding out more about the efficacy of aspirin desensitization for this condition. Does it reduce sensitivity to other allergens, such as ibuprofen & certain tree pollens (salicylate perhaps)? Does it really prevent or delay nasal polyps returning? Any dangers (when supervised by a GP)? — Preceding unsigned comment added by 95.151.241.169 ( talk) 20:13, 25 September 2013 (UTC)
Is this an allergic reaction or an intolerance? Jim Derby ( talk) 13:37, 5 March 2014 (UTC)
Neither, exactly. It is not considered an autoimmune disorder, but it is considered a chronic immune dysregulation. Andyleigh12 ( talk) 14:29, 31 July 2018 (UTC)
Is there a reason that the title of this page is Aspirin Induced Asthma as opposed to AERD (Aspirin Exacerbated Respiratory Disease) or NERD (NSAID Exacerbated Respiratory Disease)? For clarification, AERD and NERD refer to the same disorder - NERD is not used in English speaking countries due to the unfortunate acronym. Either way, "Aspirin Induced Asthma" is an outdated name for this disorder. It is referred to as AERD or NERD in all modern research. "Aspirin Induced Asthma" was moved away from because it does not adequately describe the disease, which involves more than asthma and involves all NSAIDs - not only aspirin. I would propose that the name of this page be changed to Aspirin Exacerbated Respiratory Disease since that is the most widely used name and the name used in the vast majority of modern research. Andyleigh12 ( talk) 14:41, 31 July 2018 (UTC)
"NSAIDs that are highly selective in blocking COX-2 and do not block its closely related paralog, COX-1, such as the COX-2 inhibitors celecoxib and rofecoxib, also are regarded as safe.[10]" The reference quoted to support this does not mention aspirin at all.
10. [1]
TiredOfLondon ( talk) 13:44, 24 November 2018 (UTC)
The following discussion is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
GA toolbox |
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Reviewing |
Reviewer: Etriusus ( talk · contribs) 21:06, 27 February 2023 (UTC)
GA review (see here for what the criteria are, and here for what they are not)
@
Lyall0:, I'll begin this review. I can see you've been inactive for the last month so I will give you an opportunity to respond before we get too far into this. 🏵️
Etrius (
Us) 21:06, 27 February 2023 (UTC)
'DMRT3 could be potentially involved in nasal polyp development in AERD patients. Furthermore, several genes are downregulated, hinting at the dedifferentiation phenomenon in AERD polyps.'
Lead
It is also commonly called NSAID-exacerbated respiratory disease (NERD/N-ERD), and historically aspirin-induced asthma and Samter's Triad.implies a naming history, which should just be merged with the history section rather than being its own bulleted section. Also, WP:BULLET, but I think the point is made.
Signs and symptoms
general populationthe source says "general population in the USA", which needs to be clarified. The first half of these sentence also boarders on close paraphrasing
considerably less common in parts of Asiashould be mentioned.
AERD patients may not have any allergies, though allergies are significantly more common in AERD patients than the general populationnot finding this in the source, perhaps you'll have better luck
Reactions to NSAIDs range in severity and expression. Onset is usually...check the sourcing on this paragraph, I'm finding multiple claims not backed by the source
Cause
Pathophysiology
Diagnosis
Patients are considered candidates for an AERD diagnosis if they meet the following three points:Source missing, I assume it is FN 3?
Further, if a patient meets two or more of the following criteria, then an AERD diagnosis is strongly consideredand above. Some close paraphrasing through these bulleted points. I suspect that converting this to prose will solve the issue.
During oral aspirin challenge test...gives more detail on physiological reactions
Underdiagnosis of aspirin sensitivity may be due to the lack of routine aspirin challenge testing of asthmatic patients who do not report a positive history of aspirin sensitivity.", which would be important to add
Management
much effort goes into the preventionawkward wording
Each treatment has benefits and drawbacks, so no one option can be recommended for all patients.reword
Despite optimal medical management...Not directly supported in the source
This type of asthma is not easy to treat. Half of the patients in the present study, in addition to inhaled steroids, required chronic oral corticosteroid therapy, a quarter received emergency intravenous corticosteroids treatment during the year preceding registration in the database." is what is being adapted. I don't see anywhere that states these patient were in optimal treatments and this info largely retreads previous ground.
most beneficial depending on outcome measuredreword
so the significantly higher aspirin doses used for maintenance therapy are of some concernreword and clarify what this means, what concern specifically?
This is borne out in studies..This sentence is hard to follow
highest certainty and magnitude of improvement effectreword
not qualify under stricter prescription guidelinesconfusion wording. Is it that the patient's don't qualify for these treatments?
Among biologics and aspirin desensitization and therapyWhat therapy specifically? Too many contractions
Given that dysregulation...citation missing
For example, a prospective randomized trial...it really isn't wikipedia's place to summarize methods for a study, this paragraph gets too involved with confounding variables also.
Alternate and related names
History
Comment: Do you have any previous Wikipedia experience? It's rare that new users send pages to GA, 'specially with so few edits overall. This isn't an indictment on you, I am just curious. If I've labeled something as option, it is still an improvement but is not required for the purposes of this review. I've made some copy-edits of my own, please review them when you can. Placing on hold till 03/08, please ping me if you have any questions/concerns. 🏵️ Etrius ( Us) 21:40, 1 March 2023 (UTC)
References
Aspirin-exacerbated respiratory disease was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (March 24, 2023, reviewed version). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated. |
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Aspirin-exacerbated respiratory disease.
|
Paracetamol is not an NSAID, as may be understood from the wording "though paracetamol is generally considered safe" — Preceding unsigned comment added by 88.90.68.85 ( talk) 15:32, 21 September 2011 (UTC)
The pathogenesis section is extremely confusing. In particular, the way the sentence describing differential PGE modulation I found difficult to understand. — Preceding unsigned comment added by 99.98.209.88 ( talk) 14:09, 22 January 2013 (UTC)
Has anybody else encountered this condition with the additional symptom of severe acute pain around diaphragm & back (possibly associated with gallbladder/spleen) and, later, likely autoimmune haemolytic anaemia? — Preceding unsigned comment added by 95.151.241.169 ( talk) 19:52, 25 September 2013 (UTC)
Also, interested in finding out more about the efficacy of aspirin desensitization for this condition. Does it reduce sensitivity to other allergens, such as ibuprofen & certain tree pollens (salicylate perhaps)? Does it really prevent or delay nasal polyps returning? Any dangers (when supervised by a GP)? — Preceding unsigned comment added by 95.151.241.169 ( talk) 20:13, 25 September 2013 (UTC)
Is this an allergic reaction or an intolerance? Jim Derby ( talk) 13:37, 5 March 2014 (UTC)
Neither, exactly. It is not considered an autoimmune disorder, but it is considered a chronic immune dysregulation. Andyleigh12 ( talk) 14:29, 31 July 2018 (UTC)
Is there a reason that the title of this page is Aspirin Induced Asthma as opposed to AERD (Aspirin Exacerbated Respiratory Disease) or NERD (NSAID Exacerbated Respiratory Disease)? For clarification, AERD and NERD refer to the same disorder - NERD is not used in English speaking countries due to the unfortunate acronym. Either way, "Aspirin Induced Asthma" is an outdated name for this disorder. It is referred to as AERD or NERD in all modern research. "Aspirin Induced Asthma" was moved away from because it does not adequately describe the disease, which involves more than asthma and involves all NSAIDs - not only aspirin. I would propose that the name of this page be changed to Aspirin Exacerbated Respiratory Disease since that is the most widely used name and the name used in the vast majority of modern research. Andyleigh12 ( talk) 14:41, 31 July 2018 (UTC)
"NSAIDs that are highly selective in blocking COX-2 and do not block its closely related paralog, COX-1, such as the COX-2 inhibitors celecoxib and rofecoxib, also are regarded as safe.[10]" The reference quoted to support this does not mention aspirin at all.
10. [1]
TiredOfLondon ( talk) 13:44, 24 November 2018 (UTC)
The following discussion is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
GA toolbox |
---|
Reviewing |
Reviewer: Etriusus ( talk · contribs) 21:06, 27 February 2023 (UTC)
GA review (see here for what the criteria are, and here for what they are not)
@
Lyall0:, I'll begin this review. I can see you've been inactive for the last month so I will give you an opportunity to respond before we get too far into this. 🏵️
Etrius (
Us) 21:06, 27 February 2023 (UTC)
'DMRT3 could be potentially involved in nasal polyp development in AERD patients. Furthermore, several genes are downregulated, hinting at the dedifferentiation phenomenon in AERD polyps.'
Lead
It is also commonly called NSAID-exacerbated respiratory disease (NERD/N-ERD), and historically aspirin-induced asthma and Samter's Triad.implies a naming history, which should just be merged with the history section rather than being its own bulleted section. Also, WP:BULLET, but I think the point is made.
Signs and symptoms
general populationthe source says "general population in the USA", which needs to be clarified. The first half of these sentence also boarders on close paraphrasing
considerably less common in parts of Asiashould be mentioned.
AERD patients may not have any allergies, though allergies are significantly more common in AERD patients than the general populationnot finding this in the source, perhaps you'll have better luck
Reactions to NSAIDs range in severity and expression. Onset is usually...check the sourcing on this paragraph, I'm finding multiple claims not backed by the source
Cause
Pathophysiology
Diagnosis
Patients are considered candidates for an AERD diagnosis if they meet the following three points:Source missing, I assume it is FN 3?
Further, if a patient meets two or more of the following criteria, then an AERD diagnosis is strongly consideredand above. Some close paraphrasing through these bulleted points. I suspect that converting this to prose will solve the issue.
During oral aspirin challenge test...gives more detail on physiological reactions
Underdiagnosis of aspirin sensitivity may be due to the lack of routine aspirin challenge testing of asthmatic patients who do not report a positive history of aspirin sensitivity.", which would be important to add
Management
much effort goes into the preventionawkward wording
Each treatment has benefits and drawbacks, so no one option can be recommended for all patients.reword
Despite optimal medical management...Not directly supported in the source
This type of asthma is not easy to treat. Half of the patients in the present study, in addition to inhaled steroids, required chronic oral corticosteroid therapy, a quarter received emergency intravenous corticosteroids treatment during the year preceding registration in the database." is what is being adapted. I don't see anywhere that states these patient were in optimal treatments and this info largely retreads previous ground.
most beneficial depending on outcome measuredreword
so the significantly higher aspirin doses used for maintenance therapy are of some concernreword and clarify what this means, what concern specifically?
This is borne out in studies..This sentence is hard to follow
highest certainty and magnitude of improvement effectreword
not qualify under stricter prescription guidelinesconfusion wording. Is it that the patient's don't qualify for these treatments?
Among biologics and aspirin desensitization and therapyWhat therapy specifically? Too many contractions
Given that dysregulation...citation missing
For example, a prospective randomized trial...it really isn't wikipedia's place to summarize methods for a study, this paragraph gets too involved with confounding variables also.
Alternate and related names
History
Comment: Do you have any previous Wikipedia experience? It's rare that new users send pages to GA, 'specially with so few edits overall. This isn't an indictment on you, I am just curious. If I've labeled something as option, it is still an improvement but is not required for the purposes of this review. I've made some copy-edits of my own, please review them when you can. Placing on hold till 03/08, please ping me if you have any questions/concerns. 🏵️ Etrius ( Us) 21:40, 1 March 2023 (UTC)
References