![]() | 21-Hydroxylase has been listed as one of the
Natural sciences good articles under the
good article criteria. If you can improve it further,
please do so. If it no longer meets these criteria, you can
reassess it. Review: March 28, 2021. ( Reviewed version). |
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@ Facts707, Anthony Appleyard, and Ajpolino: Concerning the recent page move, as was pointed out above, per Wikipedia chemistry naming conventions the "h" in hydroxylase should be capitalized. Also it is recommended to avoid starting sentences with a number or abbreviation. By extension, titles should follow this recommendation. Finally the IUBMB accepted name for this enzyme is Steroid 21-monooxygenase. Hence I suggest that the page be move to the IUBMB accepted name. There is a redirect by the same page name with a page history that is currently blocking this page move. Thoughts? Boghog ( talk) 07:47, 26 September 2021 (UTC)
Like Sterol 14-demethylase C-5 sterol desaturase, Sterol/Steroid always mentioned in Wikipedia Page name.-- Htmlzycq ( talk) 05:32, 27 September 2021 (UTC)
@
Anthony Appleyard and
Facts707:. The justification for the recent
page move to lowercase
21-hydroxylase was Google Scholar shows "21-hydroxylase" predominates
. Google scholar actually shows just the opposite. Chemical and enzyme names are common nouns and hence only
capitalized if they occur at the beginning of sentences. Most occurrences of
21-hydroxylase in Google Scholar occur in the middle of sentences where nothing can be concluded about capitalization. As shown by the linked examples above where 21-hydroxylase occurs at the beginning of sentences or in sentences which are in title case, upper case 21-Hydroxylase predominates. Also per
Wikipedia chemistry naming conventions the "h" in 21-hydroxylase should be capitalized. Therefore I request that the page be moved back to uppercase 21-Hydroxylase.
Boghog (
talk) 06:57, 3 October 2021 (UTC)
Per MM's focus - I looked at this document - had a few comments, it has a GA status - I am not sure that is relevant to the following comments.
My comments align with my thinking on the CYP4F2 enzyme article - opening this up to a wider audience is likely not a lot of heavy lifting.
I have made a bold comment - that I am never sure of the real target audience of many of these fairly technical articles on WP - and my comments are all focused one the single goal of expanding the consummability of such articles. And I know folks do not like bolds and such - but for me it adds emphasis - as why to why I ever made the comment.
A few casual observations:
I had to check this substrate-enzyme name - it seems to check out.
Nearly all enzymes end with the suffix of “-ase.” Generally, the names are of the form “substrate or product – reaction catalyzed.” For example, lactate dehydrogenase is for an enzyme that removes a hydrogen (plus 2e–, i.e., a hydride) from lactate, yielding the carbonyl in pyruvate. https://iubmb.qmul.ac.uk/enzyme/rules.html#:~:text=Systematic%20names%20consist%20of%20two,Rule%208.
BeingObjective ( talk) 01:02, 27 November 2023 (UTC)
Fixed it - I think.
Dr. BeingObjective ( talk) 18:41, 27 November 2023 (UTC)
I messed up the text flow around the infobox - HELP!
"Pseudogenes are common in genomes, and they originate as artifacts during the duplication process. Research has shown that retaining these faulty copies has a beneficial role, often providing regulation of their parent genes."
BeingObjective ( talk) 18:36, 27 November 2023 (UTC)
I think the protein discussion area is lightweight - I sense this was written by molecular biology type and not a biochemist.
There are many metrics that define proteins - not even sure m/wt is in there - this is an area that could have more data from an analytical biochemistry perspective.
Dr. BeingObjective ( talk) 18:47, 27 November 2023 (UTC)
https://go.drugbank.com/polypeptides/P08686 BeingObjective ( talk) 18:59, 27 November 2023 (UTC)
There is a lot in this section - and to me - is leans to CLOP -
It contains an evolutionary conserved core of a four
α-helix bundle, two additional alpha helices, two sets of
β-sheets, and a
heme
cofactor binding loop.
Each subunit in the human enzyme consists of a total of 13 α-helices and 9 β-strands that folds into a triangular prism-like tertiary structure. The iron(III) heme group that defines the active site resides in the center of each subunit.
The human enzyme binds one substrate at a time. In contrast, the well-characterized bovine enzyme can bind two substrates. The human and bovine enzyme share 80% amino acid sequence identity, but are structurally different, particularly in loop regions, and also evident in secondary structure elements. BeingObjective ( talk) 19:51, 27 November 2023 (UTC)
According to Wikipedia:Manual_of_Style/Dates_and_numbers, the editors should refrain from altering the style of elements such as date format, units, and so on, within an article unless there is a significant reason that is not merely a preference for a different style. Engaging in revert-wars over optional styles is not acceptable. If a consensus cannot be reached through discussion regarding the style to be used in an article, the style established by the first major contributor should be respected. My understanding is that this rule also applies to reference formats. Maxim Masiutin ( talk) 21:38, 3 December 2023 (UTC)
![]() | 21-Hydroxylase has been listed as one of the
Natural sciences good articles under the
good article criteria. If you can improve it further,
please do so. If it no longer meets these criteria, you can
reassess it. Review: March 28, 2021. ( Reviewed version). |
![]() | This article is rated GA-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||
|
@ Facts707, Anthony Appleyard, and Ajpolino: Concerning the recent page move, as was pointed out above, per Wikipedia chemistry naming conventions the "h" in hydroxylase should be capitalized. Also it is recommended to avoid starting sentences with a number or abbreviation. By extension, titles should follow this recommendation. Finally the IUBMB accepted name for this enzyme is Steroid 21-monooxygenase. Hence I suggest that the page be move to the IUBMB accepted name. There is a redirect by the same page name with a page history that is currently blocking this page move. Thoughts? Boghog ( talk) 07:47, 26 September 2021 (UTC)
Like Sterol 14-demethylase C-5 sterol desaturase, Sterol/Steroid always mentioned in Wikipedia Page name.-- Htmlzycq ( talk) 05:32, 27 September 2021 (UTC)
@
Anthony Appleyard and
Facts707:. The justification for the recent
page move to lowercase
21-hydroxylase was Google Scholar shows "21-hydroxylase" predominates
. Google scholar actually shows just the opposite. Chemical and enzyme names are common nouns and hence only
capitalized if they occur at the beginning of sentences. Most occurrences of
21-hydroxylase in Google Scholar occur in the middle of sentences where nothing can be concluded about capitalization. As shown by the linked examples above where 21-hydroxylase occurs at the beginning of sentences or in sentences which are in title case, upper case 21-Hydroxylase predominates. Also per
Wikipedia chemistry naming conventions the "h" in 21-hydroxylase should be capitalized. Therefore I request that the page be moved back to uppercase 21-Hydroxylase.
Boghog (
talk) 06:57, 3 October 2021 (UTC)
Per MM's focus - I looked at this document - had a few comments, it has a GA status - I am not sure that is relevant to the following comments.
My comments align with my thinking on the CYP4F2 enzyme article - opening this up to a wider audience is likely not a lot of heavy lifting.
I have made a bold comment - that I am never sure of the real target audience of many of these fairly technical articles on WP - and my comments are all focused one the single goal of expanding the consummability of such articles. And I know folks do not like bolds and such - but for me it adds emphasis - as why to why I ever made the comment.
A few casual observations:
I had to check this substrate-enzyme name - it seems to check out.
Nearly all enzymes end with the suffix of “-ase.” Generally, the names are of the form “substrate or product – reaction catalyzed.” For example, lactate dehydrogenase is for an enzyme that removes a hydrogen (plus 2e–, i.e., a hydride) from lactate, yielding the carbonyl in pyruvate. https://iubmb.qmul.ac.uk/enzyme/rules.html#:~:text=Systematic%20names%20consist%20of%20two,Rule%208.
BeingObjective ( talk) 01:02, 27 November 2023 (UTC)
Fixed it - I think.
Dr. BeingObjective ( talk) 18:41, 27 November 2023 (UTC)
I messed up the text flow around the infobox - HELP!
"Pseudogenes are common in genomes, and they originate as artifacts during the duplication process. Research has shown that retaining these faulty copies has a beneficial role, often providing regulation of their parent genes."
BeingObjective ( talk) 18:36, 27 November 2023 (UTC)
I think the protein discussion area is lightweight - I sense this was written by molecular biology type and not a biochemist.
There are many metrics that define proteins - not even sure m/wt is in there - this is an area that could have more data from an analytical biochemistry perspective.
Dr. BeingObjective ( talk) 18:47, 27 November 2023 (UTC)
https://go.drugbank.com/polypeptides/P08686 BeingObjective ( talk) 18:59, 27 November 2023 (UTC)
There is a lot in this section - and to me - is leans to CLOP -
It contains an evolutionary conserved core of a four
α-helix bundle, two additional alpha helices, two sets of
β-sheets, and a
heme
cofactor binding loop.
Each subunit in the human enzyme consists of a total of 13 α-helices and 9 β-strands that folds into a triangular prism-like tertiary structure. The iron(III) heme group that defines the active site resides in the center of each subunit.
The human enzyme binds one substrate at a time. In contrast, the well-characterized bovine enzyme can bind two substrates. The human and bovine enzyme share 80% amino acid sequence identity, but are structurally different, particularly in loop regions, and also evident in secondary structure elements. BeingObjective ( talk) 19:51, 27 November 2023 (UTC)
According to Wikipedia:Manual_of_Style/Dates_and_numbers, the editors should refrain from altering the style of elements such as date format, units, and so on, within an article unless there is a significant reason that is not merely a preference for a different style. Engaging in revert-wars over optional styles is not acceptable. If a consensus cannot be reached through discussion regarding the style to be used in an article, the style established by the first major contributor should be respected. My understanding is that this rule also applies to reference formats. Maxim Masiutin ( talk) 21:38, 3 December 2023 (UTC)