Clinical data | |
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Other names | (1α,24R)-1,24-Dihydroxyvitamin D3 |
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Topical |
ATC code | |
Identifiers | |
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CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.220.855 |
Chemical and physical data | |
Formula | C27H44O3 |
Molar mass | 416.646 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog. [1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
It is on the World Health Organization's List of Essential Medicines. [2]
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin D receptors on keratinocytes. [3] [4]
It is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. [1] It is available as an ointment or lotion.
It has also been used for vitiligo [5] [6] and Hailey-Hailey disease. [7]
Clinical data | |
---|---|
Other names | (1α,24R)-1,24-Dihydroxyvitamin D3 |
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Topical |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.220.855 |
Chemical and physical data | |
Formula | C27H44O3 |
Molar mass | 416.646 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog. [1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
It is on the World Health Organization's List of Essential Medicines. [2]
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin D receptors on keratinocytes. [3] [4]
It is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. [1] It is available as an ointment or lotion.
It has also been used for vitiligo [5] [6] and Hailey-Hailey disease. [7]