Clinical data | |
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AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code |
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Legal status | |
Legal status |
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Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.000.397 |
Chemical and physical data | |
Formula | C15H24N4O2S2 |
Molar mass | 356.50 g·mol−1 |
3D model ( JSmol) | |
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Prosultiamine ( INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. [1] [2] [3] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development. [4] [5]
It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms. [6]
Clinical data | |
---|---|
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.000.397 |
Chemical and physical data | |
Formula | C15H24N4O2S2 |
Molar mass | 356.50 g·mol−1 |
3D model ( JSmol) | |
|
Prosultiamine ( INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. [1] [2] [3] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development. [4] [5]
It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms. [6]