| TRNA (adenine57-N1/adenine58-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.219 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA (adenine57-N1/adenine58-N1)-methyltransferase ( EC 2.1.1.219, TrmI, PabTrmI, AqTrmI, MtTrmI) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine57/adenine58-N1)-methyltransferase. [1] [2] This enzyme catalyses the following chemical reaction:
- 2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA
The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs .
References
- ^ Roovers M, Wouters J, Bujnicki JM, Tricot C, Stalon V, Grosjean H, Droogmans L (2004). "A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase". Nucleic Acids Research. 32 (2): 465–76. doi: 10.1093/nar/gkh191. PMC 373318. PMID 14739239.
- ^ Guelorget A, Roovers M, Guérineau V, Barbey C, Li X, Golinelli-Pimpaneau B (October 2010). "Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase". Nucleic Acids Research. 38 (18): 6206–18. doi: 10.1093/nar/gkq381. PMC 2952851. PMID 20483913.
External links
- TRNA+(adenine57-N1/adenine58-N1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| TRNA (adenine57-N1/adenine58-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.219 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA (adenine57-N1/adenine58-N1)-methyltransferase ( EC 2.1.1.219, TrmI, PabTrmI, AqTrmI, MtTrmI) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine57/adenine58-N1)-methyltransferase. [1] [2] This enzyme catalyses the following chemical reaction:
- 2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA
The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs .
References
- ^ Roovers M, Wouters J, Bujnicki JM, Tricot C, Stalon V, Grosjean H, Droogmans L (2004). "A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase". Nucleic Acids Research. 32 (2): 465–76. doi: 10.1093/nar/gkh191. PMC 373318. PMID 14739239.
- ^ Guelorget A, Roovers M, Guérineau V, Barbey C, Li X, Golinelli-Pimpaneau B (October 2010). "Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase". Nucleic Acids Research. 38 (18): 6206–18. doi: 10.1093/nar/gkq381. PMC 2952851. PMID 20483913.
External links
- TRNA+(adenine57-N1/adenine58-N1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)