Tumor necrosis factor ligand superfamily member 18 is a
protein that in humans is encoded by the TNFSF18gene.[5][6][7]
The protein encoded by this gene is a
cytokine that belongs to the
tumor necrosis factor (TNF) ligand family. This cytokine is a
ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate
T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in
endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.[7]
Yu KY, Kim HS, Song SY, et al. (2003). "Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells". Biochem. Biophys. Res. Commun. 310 (2): 433–8.
doi:
10.1016/j.bbrc.2003.09.024.
PMID14521928.
Bae EM, Kim WJ, Suk K, et al. (2007). "Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages". Mol. Immunol. 45 (2): 523–33.
doi:
10.1016/j.molimm.2007.05.013.
PMID17602748.
Tumor necrosis factor ligand superfamily member 18 is a
protein that in humans is encoded by the TNFSF18gene.[5][6][7]
The protein encoded by this gene is a
cytokine that belongs to the
tumor necrosis factor (TNF) ligand family. This cytokine is a
ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate
T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in
endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.[7]
Yu KY, Kim HS, Song SY, et al. (2003). "Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells". Biochem. Biophys. Res. Commun. 310 (2): 433–8.
doi:
10.1016/j.bbrc.2003.09.024.
PMID14521928.
Bae EM, Kim WJ, Suk K, et al. (2007). "Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages". Mol. Immunol. 45 (2): 523–33.
doi:
10.1016/j.molimm.2007.05.013.
PMID17602748.