SARAF is a
protein that in humans is encoded by the SARAFgene, formerly known as TMEM66 (transmembrane protein 66).[5][6]
Function
SARAF (TMEM66) is a negative regulator of the
store-operated calcium channel (SOCE) into cells. SARAF is an
endoplasmic reticulum (ER) membrane resident protein that associates with
STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping
cytoplasmiccalcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.[7]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
SARAF is a
protein that in humans is encoded by the SARAFgene, formerly known as TMEM66 (transmembrane protein 66).[5][6]
Function
SARAF (TMEM66) is a negative regulator of the
store-operated calcium channel (SOCE) into cells. SARAF is an
endoplasmic reticulum (ER) membrane resident protein that associates with
STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping
cytoplasmiccalcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.[7]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.