Combination of | |
---|---|
Dolutegravir | Integrase strand transfer inhibitor |
Lamivudine | Nucleoside reverse transcriptase inhibitor |
Tenofovir disoproxil | Nucleoside reverse transcriptase inhibitor |
Clinical data | |
Other names | Tenofovir/lamivudine/dolutegravir (TLD) |
Routes of administration | By mouth |
ATC code |
Dolutegravir/lamivudine/tenofovir (DTG/3TC/TDF) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. [1] It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil. [1] As of 2019 [update], it is listed by the World Health Organization (WHO) as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative. [2] It is taken by mouth. [3]
Side effects may include trouble sleeping, weight gain, and rash. [2] [3] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. [2] Use remains recommended after the first trimester. [2] Use is not recommended in those with kidney problems. [3] The combination is a type of antiretroviral therapy. [2]
It is on the World Health Organization's List of Essential Medicines. [4] In some countries it is available as a generic medication. [5] It is tentatively approved in the United States as of 2019, full approval is pending expiration of the US patents on dolutegravir (Tivicay) and tenofovir disoproxil (Viread). [6] [7]
As of 2019, it is listed by the World Health Organization (WHO) as the first-line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative. [2] It may be used in people with both HIV and tuberculosis, however if the person is on rifampicin a larger dose of dolutegravir is needed. [2]
Side effects may include trouble sleeping and weight gain. [2] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. [2] Use remains recommended after the first trimester. [2] It should not be used with dofetilide. [3]
In the developing world it costs about US$75 per year. [8] It is considered more cost effective than tenofovir/lamivudine/efavirenz as of 2019. [2]
Combination of | |
---|---|
Dolutegravir | Integrase strand transfer inhibitor |
Lamivudine | Nucleoside reverse transcriptase inhibitor |
Tenofovir disoproxil | Nucleoside reverse transcriptase inhibitor |
Clinical data | |
Other names | Tenofovir/lamivudine/dolutegravir (TLD) |
Routes of administration | By mouth |
ATC code |
Dolutegravir/lamivudine/tenofovir (DTG/3TC/TDF) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. [1] It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil. [1] As of 2019 [update], it is listed by the World Health Organization (WHO) as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative. [2] It is taken by mouth. [3]
Side effects may include trouble sleeping, weight gain, and rash. [2] [3] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. [2] Use remains recommended after the first trimester. [2] Use is not recommended in those with kidney problems. [3] The combination is a type of antiretroviral therapy. [2]
It is on the World Health Organization's List of Essential Medicines. [4] In some countries it is available as a generic medication. [5] It is tentatively approved in the United States as of 2019, full approval is pending expiration of the US patents on dolutegravir (Tivicay) and tenofovir disoproxil (Viread). [6] [7]
As of 2019, it is listed by the World Health Organization (WHO) as the first-line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative. [2] It may be used in people with both HIV and tuberculosis, however if the person is on rifampicin a larger dose of dolutegravir is needed. [2]
Side effects may include trouble sleeping and weight gain. [2] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use. [2] Use remains recommended after the first trimester. [2] It should not be used with dofetilide. [3]
In the developing world it costs about US$75 per year. [8] It is considered more cost effective than tenofovir/lamivudine/efavirenz as of 2019. [2]