TC-S 7001 (Azaindole-1) is a drug which acts as a potent and selective inhibitor of the
enzymeRho kinase, with an IC50 of 0.6 nM at
ROCK1 and 1.1 nM at
ROCK2.[1] It has
vasodilatory effects and has been used in research for a variety of applications.[2][3][4]
^Pankey EA, Byun RJ, Smith WB, Bhartiya M, Bueno FR, Badejo AM, et al. (July 2012). "The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat". Canadian Journal of Physiology and Pharmacology. 90 (7): 825–35.
doi:
10.1139/y2012-061.
PMID22591047.
TC-S 7001 (Azaindole-1) is a drug which acts as a potent and selective inhibitor of the
enzymeRho kinase, with an IC50 of 0.6 nM at
ROCK1 and 1.1 nM at
ROCK2.[1] It has
vasodilatory effects and has been used in research for a variety of applications.[2][3][4]
^Pankey EA, Byun RJ, Smith WB, Bhartiya M, Bueno FR, Badejo AM, et al. (July 2012). "The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat". Canadian Journal of Physiology and Pharmacology. 90 (7): 825–35.
doi:
10.1139/y2012-061.
PMID22591047.