20:1420:14, 6 April 2023diffhist−562
Lychee
→Phytochemicals: remove BHT as a natural product. BHT is a contaminant that is used as an antioxidant in the solvents used for chemical analysis. BHT is regularly found in extracts and is often reported by inexperienced scientists... More evidence would be required to prove a natural origin.
12:5312:53, 23 October 2021diffhist−208
2,4,6-Trichloroanisole
rtm "The odor of TCA is not directly perceived. Instead, the molecule distorts the perception of smell by suppressing olfactory" This is an over-interpretation of the paper and can obviously not be true (e.g. homeopathic concentrations) as even discussed in the paper itself. The paper uses newt (!) olfactory epithelium, no surprise that they smell different things than humans.
19 October 2021
21:0521:05, 19 October 2021diffhist−157
Digital polymerase chain reaction
→Principles: rm "Since PCR is an exponential process, only twofold differences in amplification can be observed, greatly impacting the validity and precision of the results." - not true because product yields over several cycles are compared (shifted curves)
14:0714:07, 11 February 2021diffhist−264
M-alpha-HMCA
→top: rm speculations and suggestions about psychoactive effects. It is clearly an unintentional sideproduct in dirty MDMA. There is no reason to believe it could be psychoactive as even small sidechain substitutions abolish MDMA activity. Also, M-ALPHA was not clearly described as being empathogenic.
22:2422:24, 18 September 2020diffhist−160
Hottest chili pepper
→Super-hots: rm "Super-hots also have "rumpled walls", likely a genetic mutation, resulting in more area in which to store capsaicin and therefore more heat.<ref name=":11" />" not true, bumps are only on the outside and the form has no effect on dry weight capsaicin levels whatsoever
18:3818:38, 3 May 2020diffhist−829
Ethyl butylacetylaminopropionate
rm highly problematic mechanism of action paragraph that put undue weight on a single publication and that runs against the scientific consensus. If it would indeed be only physical effects, then all compounds of similar vapor pressure would be effective insect repellents.
20:1420:14, 6 April 2023diffhist−562
Lychee
→Phytochemicals: remove BHT as a natural product. BHT is a contaminant that is used as an antioxidant in the solvents used for chemical analysis. BHT is regularly found in extracts and is often reported by inexperienced scientists... More evidence would be required to prove a natural origin.
12:5312:53, 23 October 2021diffhist−208
2,4,6-Trichloroanisole
rtm "The odor of TCA is not directly perceived. Instead, the molecule distorts the perception of smell by suppressing olfactory" This is an over-interpretation of the paper and can obviously not be true (e.g. homeopathic concentrations) as even discussed in the paper itself. The paper uses newt (!) olfactory epithelium, no surprise that they smell different things than humans.
19 October 2021
21:0521:05, 19 October 2021diffhist−157
Digital polymerase chain reaction
→Principles: rm "Since PCR is an exponential process, only twofold differences in amplification can be observed, greatly impacting the validity and precision of the results." - not true because product yields over several cycles are compared (shifted curves)
14:0714:07, 11 February 2021diffhist−264
M-alpha-HMCA
→top: rm speculations and suggestions about psychoactive effects. It is clearly an unintentional sideproduct in dirty MDMA. There is no reason to believe it could be psychoactive as even small sidechain substitutions abolish MDMA activity. Also, M-ALPHA was not clearly described as being empathogenic.
22:2422:24, 18 September 2020diffhist−160
Hottest chili pepper
→Super-hots: rm "Super-hots also have "rumpled walls", likely a genetic mutation, resulting in more area in which to store capsaicin and therefore more heat.<ref name=":11" />" not true, bumps are only on the outside and the form has no effect on dry weight capsaicin levels whatsoever
18:3818:38, 3 May 2020diffhist−829
Ethyl butylacetylaminopropionate
rm highly problematic mechanism of action paragraph that put undue weight on a single publication and that runs against the scientific consensus. If it would indeed be only physical effects, then all compounds of similar vapor pressure would be effective insect repellents.