Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind from being translated. [1] In contrast to siRNA, stRNAs downregulate expression of target RNAs after translation initiation without affecting mRNA stability. [2] Nowadays, stRNAs are better known as miRNAs.
stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/ AGO1 family of proteins, which are better known for their roles in RNA interference ( RNAi). stRNAs may function to control temporal identity during development in C. elegans and other organisms. [3]
References
- ^ Ambros V (August 2001). "Development. Dicing up RNAs". Science. 293 (5531): 811–3. doi: 10.1126/science.1064400. PMID 11486075. S2CID 45706655.
- ^ Grosshans H, Slack FJ (January 2002). "Micro-RNAs: small is plentiful". The Journal of Cell Biology. 156 (1): 17–21. doi: 10.1083/jcb.200111033. PMC 2173595. PMID 11781331.
- ^ Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression". BioEssays. 24 (2): 119–29. doi: 10.1002/bies.10046. PMID 11835276.
Types of
nucleic acids | |||||||
|---|---|---|---|---|---|---|---|
| Constituents | |||||||
|
Ribonucleic acids (coding, non-coding) |
| ||||||
|
Deoxyribonucleic acids | |||||||
| Analogues | |||||||
| Cloning vectors | |||||||
 | This molecular biology article is a stub. You can help Wikipedia by expanding it. |
Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind from being translated. [1] In contrast to siRNA, stRNAs downregulate expression of target RNAs after translation initiation without affecting mRNA stability. [2] Nowadays, stRNAs are better known as miRNAs.
stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/ AGO1 family of proteins, which are better known for their roles in RNA interference ( RNAi). stRNAs may function to control temporal identity during development in C. elegans and other organisms. [3]
References
- ^ Ambros V (August 2001). "Development. Dicing up RNAs". Science. 293 (5531): 811–3. doi: 10.1126/science.1064400. PMID 11486075. S2CID 45706655.
- ^ Grosshans H, Slack FJ (January 2002). "Micro-RNAs: small is plentiful". The Journal of Cell Biology. 156 (1): 17–21. doi: 10.1083/jcb.200111033. PMC 2173595. PMID 11781331.
- ^ Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression". BioEssays. 24 (2): 119–29. doi: 10.1002/bies.10046. PMID 11835276.
Types of
nucleic acids | |||||||
|---|---|---|---|---|---|---|---|
| Constituents | |||||||
|
Ribonucleic acids (coding, non-coding) |
| ||||||
|
Deoxyribonucleic acids | |||||||
| Analogues | |||||||
| Cloning vectors | |||||||
|
| This molecular biology article is a stub. You can help Wikipedia by expanding it. |