Sarcosine/dimethylglycine N-methyltransferase ( EC 2.1.1.157, ApDMT, sarcosine-dimethylglycine methyltransferase, SDMT, sarcosine dimethylglycine N-methyltransferase, S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase (N,N-dimethylglycine(or betaine)-forming). ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + sarcosine ${\displaystyle \rightleftharpoons }$ 2 S-adenosyl-L-homocysteine + betaine (overall reaction)

(1a) S-adenosyl-L-methionine + sarcosine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N,N-dimethylglycine

(1b) S-adenosyl-L-methionine + N,N-dimethylglycine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + betaine

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.

References

External links

• Sarcosine/dimethylglycine+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)